UAP1

UAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JV1, 1JV3, 1JVD, 1JVG
Identifiers
Aliases	UAP1, AGX, AGX1, AGX2, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1
External IDs	OMIM: 602862 MGI: 1334459 HomoloGene: 2342 GeneCards: UAP1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,601,240 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,002,526 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; parotid gland; ; gastric mucosa; ; bronchial epithelial cell; ; pericardium; ; synovial membrane; ; Achilles tendon; ; vena cava; ; jejunal mucosa; ; body of pancreas;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; morula; ; left colon; ; ankle joint; ; cumulus cell; ; conjunctival fornix; ; Paneth cell; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; uridylyltransferase activity; nucleotidyltransferase activity; carbohydrate binding; identical protein binding; UDP-N-acetylglucosamine diphosphorylase activity;
Cellular component	plasma membrane; nucleoplasm; cytoplasm; cytosol;
Biological process	UDP-N-acetylglucosamine metabolic process; metabolism; UDP-N-acetylglucosamine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6675
	107652
	ENSG00000117143
	ENSMUSG00000026670
	Q16222
	Q91YN5
NM_003115; NM_001324113; NM_001324114; NM_001324115; NM_001324116;
	NM_001324117; NM_001388401; NM_001388402; NM_001399790; NM_001399791; NM_001399792; NM_001399793
	NM_133806; NM_001305045; NM_001305046
NP_001311042; NP_001311043; NP_001311044; NP_001311045; NP_001311046;
	NP_003106
	NP_001291974; NP_001291975; NP_598567
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
↑ Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
↑ "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304. S2CID 25271682.
Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9603950-5] Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.

[pmid8025165-6] Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.

[entrez-7] "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

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[3]

[4]

[5]

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[7]

References

Further reading