VPS18
Identifiers
AliasesVPS18, PEP3, CORVET/HOPS core subunit, VPS18 core subunit of CORVET and HOPS complexes
External IDsOMIM: 608551 MGI: 2443626 HomoloGene: 13302 GeneCards: VPS18
Orthologs
SpeciesHumanMouse
Entrez

57617

228545

Ensembl

ENSG00000104142

ENSMUSG00000034216

UniProt

Q9P253

Q8R307

RefSeq (mRNA)

NM_020857

NM_172269

RefSeq (protein)

NP_065908
NP_065908.1

NP_758473

Location (UCSC)Chr 15: 40.89 – 40.9 MbChr 2: 119.12 – 119.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.[5][6][7]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[7]

Interactions

VPS18 has been shown to interact with VPS11[8] and STX7.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104142 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034216 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (March 2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene. 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
  6. Yogosawa S, Hatakeyama S, Nakayama KI, Miyoshi H, Kohsaka S, Akazawa C (Dec 2005). "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase". J Biol Chem. 280 (50): 41619–27. doi:10.1074/jbc.M508397200. PMID 16203730.
  7. 1 2 "Entrez Gene: VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)".
  8. 1 2 Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.

Further reading


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