Yaakov Stern is an American cognitive neuroscientist, professor of neuropsychology at Columbia University.

Early life

Stern has an undergraduate degree in psychology from Touro College, and a doctorate in psychology from the Graduate Center of the City University of New York. He joined the faculty at Columbia University after completing his doctorate. He now is a Florence Irving professor of neuropsychology and chief of the Cognitive Neuroscience Division of the Neurology department.[1]

Cognitive reserve

Stern’s major contribution is the concept of cognitive reserve, which helps to explain differential susceptibility to age- or disease-related brain changes. In 2002 he published his first systematic treatment of the concept.[2] Stern's work in cognitive reserve is the most cited in the list of 300 papers in Alzheimer's Disease research compiled by the Journal of Alzheimer's Disease[3] and has been quoted in news articles.[4][5][6]

In 1992, he demonstrated that when patients with Alzheimer's disease are matched for clinical severity, those with higher education had more extensive neurodegeneration, indicating that they could cope more successfully with the underlying pathology.[7] He was one of the first to use prospective incidence studies to demonstrate that individuals with higher educational or occupational attainment,[8] or who engage in more late life leisure activities[9] have a reduced risk of developing Alzheimer's. He was the first to observe that patients with higher reserve had a more rapid rate of decline.[10] Much of his later work has focused on the potential neural basis of cognitive reserve using imaging studies.[11]

Stern has authored or co-authored and published over 600 articles in academic journals. His H index according to Google scholar is over 150. He edited a book on cognitive reserve.[12]

Other research

Stern’s earliest work focused on identifying cognitive changes in nondemented patients with idiopathic Parkinson’s disease, which helped identify the cognitive role of the basal ganglia when it was widely believed to have a role only in motor function.[13] He validated these observations in patients with MPTP-induced Parkinson's.[14]

In the long-standing Predictors study, Stern has been working to clarify the heterogeneity of the course of Alzheimer's disease. He identified a set of disease features that are associated with more rapid decline, and created prediction algorithms for disease course.[15]

Stern directs the Reference Ability Neural Network (RANN) study, which is examining the neural basis for key cognitive domains in aging.[16]

References

  1. ↑ "Bio". 14 October 2020.
  2. ↑ Stern, Y. (2002). "What is cognitive reserve? Theory and research application of the reserve concept". Journal of the International Neuropsychological Society. 8 (3): 448–460. doi:10.1017/s1355617702813248. PMID 11939702. S2CID 9902333.
  3. ↑ "Journal of Alzheimer's Disease".
  4. ↑ Heidi Godman (December 21, 2018). "Can I Bank Cognition Now for Old Age?". U.S. News & World Report.
  5. ↑ "Five myths about Alzheimer's disease". June 15, 2018.
  6. ↑ Cecilia Pessoa Gingerich (April 17, 2018). "Physicians with Alzheimer's: What Happens When a Doctor Forgets?".
  7. ↑ Stern, Y.; Alexander, GE; Prohovnik, I.; Mayeux, R. (1992). "Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease". Annals of Neurology. 32 (3): 371–375. doi:10.1002/ana.410320311. PMID 1416806. S2CID 20777087.
  8. ↑ Stern, Y.; Gurland, B.; Tatemichi, TK; Tang, MX; Wilder, D.; Mayeux, R. (1994). "Influence of education and occupation on the incidence of Alzheimer's disease". Journal of the American Medical Association. 271 (13): 1004–1010. doi:10.1001/jama.1994.03510370056032. PMID 8139057.
  9. ↑ Scarmeas, N.; Levy, G.; Tang, MX; Manly, J.; Stern, Y. (2001). "Influence of leisure activity on the incidence of Alzheimer's disease". Neurology. 57 (12): 2236–2242. doi:10.1212/wnl.57.12.2236. PMC 3025284. PMID 11756603.
  10. ↑ Stern, Y.; Albert, S.; Tang, MX; Tsai, WY (1999). "Rate of memory decline in AD is related to education and occupation: Cognitive reserve?". Neurology. 53 (9): 1942–1957. doi:10.1212/wnl.53.9.1942. PMID 10599762. S2CID 5676450.
  11. ↑ Stern, Y. (2009). "Cognitive reserve". Neuropsychologia. 47 (10): 2015–2028. doi:10.1016/j.neuropsychologia.2009.03.004. PMC 2739591. PMID 19467352.
  12. ↑ Stern, Yaakov (2006). Cognitive Reserve: Theory and Applications (1st ed.). New York and London: Taylor & Francis. ISBN 9781138006263.
  13. ↑ Stern, Y.; Mayeux, R.; Rosen, J.; Ilson, J. (1983). "Perceptual motor dysfunction in Parkinson's disease: a deficit in sequential and predictive voluntary movement". Journal of Neurology, Neurosurgery, and Psychiatry. 46 (2): 145–151. doi:10.1136/jnnp.46.2.145. PMC 1027297. PMID 6842218.
  14. ↑ Stern, Y.; Langston, JW (1985). "Intellectual changes in patients with MPTP-induced parkinsonism". Neurology. 35 (10): 1506–1509. doi:10.1212/wnl.35.10.1506. PMID 3875807. S2CID 7914649.
  15. ↑ Stern, Y.; Tang, MX; Albert, MS (1997). "Predicting time to nursing home care and death in individuals with Alzheimer disease". Journal of the American Medical Association. 277 (10): 806–812. doi:10.1001/jama.277.10.806. PMID 9052710.
  16. ↑ Stern, Y.; Habeck, C.; Steffener, J. (2014). "The Reference Ability Neural Network Study: motivation, design, and initial feasibility analyses". NeuroImage. 103: 139–151. doi:10.1016/j.neuroimage.2014.09.029. PMC 4312259. PMID 25245813.
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