Yiliang Ding
Headshot of Dr. Yiliang Ding
Born(1982-09-08)September 8, 1982
NationalityChinese
EducationShanghai Jiao Tong University
University of East Anglia
Scientific career
FieldsRNA Biology
Plant Biology
InstitutionsJohn Innes Centre

Babraham Institute

University of East Anglia
Doctoral advisorGiles Oldroyd
Websitewww.jic.ac.uk/people/yilliang-ding

Yiliang Ding has been a group leader with tenure at the John Innes Centre since 2014, working on the functional roles of the RNA structure in living cells.[1][2] She has also been an Honorary Group Leader at the Babraham Institute and an Honorary Associate Professor at the University of East Anglia since 2022.        

Education

Yiliang received a bachelor's degree from the Shanghai Jiao Tong University in 2005. She studied for her PhD at the John Innes Centre under the supervision of Professor Giles Oldroyd between October 2005 and November 2009. She was a John Innes Foundation Rotation Programme student, with Marie Curie Fellowships - Early stage research training and chose to study the regulation of legume nodulation, receiving her PhD from the University of East Anglia in 2009.[3][4]

Career and research

Yiliang spent two months in the lab of David Lilley at the University of Dundee between November and December 2009.[5] Prior to her move to the John Innes Centre as a group leader, Yiliang worked as a Postdoctoral Scholar at Penn State University, where she worked on the structural folding of RNA under the Human Frontier Science Program Grant from 2010 to 2013. Yiliang obtained the David Phillips Fellowship and started her own group at the John Innes Centre in 2014. She was granted tenure at the John Innes Centre in 2019. Yiliang's group researches RNA structure and post-transcriptional gene regulations. Her group’s research on nucleic acid chemistry and RNA biology focuses on understanding the dynamics of RNA structure in living cells. Yiliang develops new approaches for revealing in vivo RNA structurome. In particular her work on a high throughput method, Structure-seq, to analyse one of the first two genome-wide in vivo RNA structure maps, was published in Nature in 2013.[6] This paper "In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features" has been widely cited[7][8][9] as a method for in vivo RNA structural analysis.[10]

Since 2014, Yiliang's group has been studying the functional roles of RNA structure in diverse biological processes such as mRNA processing (splicing and polyadenylation),[11] phase separation,[12] translation,[13] and RNA degradation.[14] Yiliang's group has also developed new methods to reveal the existence of tertiary RNA G-quadruplex structures in eukaryotes[15] and uncovered that RNA G-quadruplex structure serves as a molecular marker to facilitate plant adaptation to the cold during evolution.[16] Recently, Yiliang's group has developed the single-molecule RNA structure profiling method that is capable of dissecting individual RNA structure conformation in living cells for the first time. The group revealed the functional importance of RNA structure in long noncoding RNAs.[17] She is a member of the editorial board of Nucleic Acids Research.

Awards and honours

Yiliang Ding received several awards and recognitions since she established her own lab in 2014. She has successfully achieved eight grants (~£5.5 M in total). Notably, she has achieved a series of distinguished awards: a BBSRC David Phillips Fellowship,[18] a 5-year H2020 ERC Starting Grant and an associated ERC Proof of Concept grant, and more recently a 5-year H2020 ERC Consolidator Grant.[19]

References

  1. ↑ "Five new Project Leaders join the John Innes Centre". John Innes Centre. 14 November 2014. Retrieved 10 August 2023.
  2. ↑ "Dr Yiliang Ding". John Innes Centre. 30 November 2018. Retrieved 10 August 2023.
  3. ↑ "Abscisic Acid Coordinates Nod Factor and Cytokinin Signaling during the Regulation of Nodulation in Medicago truncatula". academic.oup.com. Retrieved 10 August 2023.
  4. ↑ "NIN Transcription Factor Coordinates Diverse Nodulation Programs in Different Tissues of the Medicago truncatula Root". academic.oup.com. Retrieved 10 August 2023.
  5. ↑ "Professor David Lilley". University of Dundee. Retrieved 10 August 2023.
  6. ↑ Assmann, Sarah M.; Bevilacqua, Philip C.; Yu Zhang; Kwok, Chun Kit; Tang, Yin; Ding, Yiliang (January 2014). "In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features". Nature. 505 (7485): 696–700. Bibcode:2014Natur.505..696D. doi:10.1038/nature12756. ISSN 1476-4687. PMID 24270811. S2CID 205236375.
  7. ↑ Van Dijk, Erwin L.; Auger, Hélène; Jaszczyszyn, Yan; Thermes, Claude (September 2014). "Ten years of next-generation sequencing technology". Trends in Genetics. 30 (9): 418–426. doi:10.1016/j.tig.2014.07.001. PMID 25108476.
  8. ↑ Tuschl, Thomas; Hafner, Markus; Gerstberger, Stefanie (December 2014). "A census of human RNA-binding proteins". Nature Reviews Genetics. 15 (12): 829–845. doi:10.1038/nrg3813. ISSN 1471-0064. PMID 25365966. S2CID 7882934.
  9. ↑ Pan, Tao; Parisien, Marc; Chuan He; Zheng, Guanqun; Dai, Qing; Liu, Nian (February 2015). "N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions". Nature. 518 (7540): 560–564. Bibcode:2015Natur.518..560L. doi:10.1038/nature14234. ISSN 1476-4687. PMC 4355918. PMID 25719671.
  10. ↑ "Google Scholar User Profile". Google Scholar. Retrieved 17 December 2019.
  11. ↑ Liu, Zhenshan; Liu, Qi; Yang, Xiaofei; Zhang, Yueying; Norris, Matthew; Chen, Xiaoxi; Cheema, Jitender; Zhang, Huakun; Ding, Yiliang (4 January 2021). "In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants". Genome Biology. 22 (1): 11. doi:10.1186/s13059-020-02236-4. ISSN 1474-760X. PMC 7784297. PMID 33397430.
  12. ↑ "G-quadruplex structures trigger RNA phase separation". academic.oup.com. Retrieved 10 August 2023.
  13. ↑ "Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants" (PDF). Molecular Plant.
  14. ↑ "Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo". Retrieved 10 August 2023.
  15. ↑ Yang, Xiaofei; Cheema, Jitender; Zhang, Yueying; Deng, Hongjing; Duncan, Susan; Umar, Mubarak Ishaq; Zhao, Jieyu; Liu, Qi; Cao, Xiaofeng; Kwok, Chun Kit; Ding, Yiliang (1 September 2020). "RNA G-quadruplex structures exist and function in vivo in plants". Genome Biology. 21 (1): 226. doi:10.1186/s13059-020-02142-9. ISSN 1474-760X. PMC 7466424. PMID 32873317.
  16. ↑ Yang, Xiaofei; Yu, Haopeng; Duncan, Susan; Zhang, Yueying; Cheema, Jitender; Liu, Haifeng; Benjamin Miller, J.; Zhang, Jie; Kwok, Chun Kit; Zhang, Huakun; Ding, Yiliang (20 October 2022). "RNA G-quadruplex structure contributes to cold adaptation in plants". Nature Communications. 13 (1): 6224. doi:10.1038/s41467-022-34040-y. ISSN 2041-1723. PMC 9585020. PMID 36266343.
  17. ↑ Yang, Minglei; Zhu, Pan; Cheema, Jitender; Bloomer, Rebecca; Mikulski, Pawel; Liu, Qi; Zhang, Yueying; Dean, Caroline; Ding, Yiliang (September 2022). "In vivo single-molecule analysis reveals COOLAIR RNA structural diversity". Nature. 609 (7926): 394–399. doi:10.1038/s41586-022-05135-9. ISSN 1476-4687. PMC 9452300. PMID 35978193.
  18. ↑ "The role of RNA structures in plant response to temperature".
  19. ↑ "ERC Consolidator Grants 2022" (PDF).
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