ZNF444
Identifiers
Aliases	ZNF444, EZF-2, EZF2, ZSCAN17, zinc finger protein 444
External IDs	OMIM: 607874 MGI: 1923365 HomoloGene: 10139 GeneCards: ZNF444
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 56,132,599 bp[1] End 56,160,893 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 6,175,225 bp[2] End 6,196,810 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb vena cava right uterine tube right lobe of liver cerebellar vermis body of pancreas thoracic diaphragm cingulate gyrus pancreatic ductal cell fundus Top expressed in yolk sac spermatocyte superior frontal gyrus proximal tubule neural tube thymus spermatid ganglionic eminence lip lens More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding metal ion binding DNA-binding transcription factor activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55311 72667 Ensembl ENSG00000167685 ENSMUSG00000044876 UniProt Q8N0Y2 n/a RefSeq (mRNA) NM_001253792 NM_018337 NM_001146024 NM_028316 RefSeq (protein) NP_001240721 NP_060807 NP_001240721.1 n/a Location (UCSC) Chr 19: 56.13 – 56.16 Mb Chr 7: 6.18 – 6.2 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene. ^[5]

Function

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) (Adachi H, Tsujimoto M (2002). "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem. 277 (27): 24014–21. doi:10.1074/jbc.M201854200. PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.