Zinc finger protein 266

ZNF266
Identifiers
Aliases	ZNF266, HZF1, zinc finger protein 266
External IDs	OMIM: 604751 MGI: 1924769 HomoloGene: 105676 GeneCards: ZNF266
Gene location (Human)
Chr.	Chromosome 19 (human)
End	9,435,571 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,432,713 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; tibia; ; spleen; ; parietal pleura; ; gastric mucosa; ; superficial temporal artery; ; spongy bone; ; hair follicle; ; corpus epididymis; ; cardia;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; primitive streak; ; medial ganglionic eminence; ; epidermis; ; hair follicle; ; left lung lobe; ; maxillary prominence; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10781
	77519
	ENSG00000174652
	ENSMUSG00000060510
	Q14584
	n/a
	NM_001271314; NM_006631; NM_198058
	NM_001082485; NM_001135019
NP_001258243; NP_006622; NP_001357303; NP_001357304; NP_001357305;
	NP_001357306; NP_001357307; NP_001357308; NP_001357309; NP_001357310; NP_001357311; NP_001357312; NP_001357313; NP_001357314; NP_001357315; NP_001357316; NP_001357317; NP_001357318; NP_001357319; NP_001357320; NP_001357321; NP_001357322; NP_001357323; NP_001357324; NP_001357325; NP_001357326; NP_001357327; NP_001357328; NP_001357329
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene. ^[5]

Function

This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174652 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060510 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger protein 266". Retrieved 2015-08-03.

Liu X, Jin EZ, Zhi JX, Li XQ (2011). "Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports. 4 (3): 465–9. doi:10.3892/mmr.2011.465. PMID 21468593.
Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
Peng H, Du ZW, Zhang JW (Jun 2006). "Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells". Leukemia. 20 (6): 1109–16. doi:10.1038/sj.leu.2404212. PMID 16628192.
Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW (2011). "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1". Molecular Medicine Reports. 4 (6): 1131–7. doi:10.3892/mmr.2011.564. PMID 21874239.
Deng MJ, Li XB, Peng H, Zhang JW (Feb 2010). "Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16)". Molecular Biotechnology. 44 (2): 83–9. doi:10.1007/s12033-009-9210-8. PMID 19763908. S2CID 3470718.
Gamsjaeger R, Liew CK, Loughlin FE, Crossley M, Mackay JP (Feb 2007). "Sticky fingers: zinc-fingers as protein-recognition motifs". Trends in Biochemical Sciences. 32 (2): 63–70. doi:10.1016/j.tibs.2006.12.007. PMID 17210253.
Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK (Sep 2010). "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease". Human Molecular Genetics. 19 (17): 3482–8. doi:10.1093/hmg/ddq264. PMID 20601676.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174652 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060510 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 266". Retrieved 2015-08-03.

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Function

References

Further reading