一叶萩碱

一叶萩碱（浅黄色晶体，化学式：C13H15NO2）是一种发现于一叶萩[1]和珠子草[2]的生物碱。它具有促惊厥作用，[3][4]且具有强烈的痉挛作用，类似于士的宁。[5]它是一种GABA-A拮抗剂。[6][7]

一叶萩碱
识别
  • (1S,2R,8S)-14-Oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
CAS号5610-40-2
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.222.962
化学
化学式C13H15NO2
摩尔质量217.27 g·mol−1
3D模型（JSmol）
  • C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
  • InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
  • Key:SWZMSZQQJRKFBP-WZRBSPASSA-N

参考文献
  1. Wang DS, Fang LH, Du GH. . . Springer Singapore. 2018: 325–330. ISBN 978-981-10-8021-0. doi:10.1007/978-981-10-8022-7_54.
  2. Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. . Journal of Ethnopharmacology. November 2011, 138 (2): 286–313. PMID 21982793. doi:10.1016/j.jep.2011.09.040.
  3. Tao, S. C.; Peng, J. Z.; Lu, M. W. . Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 1986, 7 (1): 9–12. PMID 2876581.
  4. Zhang, S. C.; Li, S. Z.; Gao, X. C.; Qian, L. H.; Yang, M. Z.; Yuan, H. N.; Tan, D. J. . Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 1993, 18 (7): 387–391. PMID 8267848.
  5. Klochkov, Sergey; Neganova, Margarita. . RSC Advances. 2021, 11 (31): 19185–19195. Bibcode:2021RSCAd..1119185K. PMC 9033663 可免费查阅. PMID 35478659. doi:10.1039/D1RA02558A 可免费查阅.
  6. . PubChem, US National Library of Medicine. 2020-07-04 [2022-12-27]. （原始内容存档于2022-12-27）.
  7. Beutler, J. A.; Karbon, E. W.; Brubaker, A. N.; Malik, R.; Curtis, D. R.; Enna, S. J. . Brain Research. 1985, 330 (1): 135–140. PMID 2985189. S2CID 21138482. doi:10.1016/0006-8993(85)90014-9.
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