主要碱性蛋白

主要碱性蛋白
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1H8U、2BRS、4QXX
識別號
别名	PRG2；, BMPG, MBP, MBP1, proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), proMBP, proteoglycan 2, pro eosinophil major basic protein
外部ID	OMIM：605601 MGI：103294 HomoloGene：2044 GeneCards：PRG2
基因位置（人类）
染色体	11號染色體[1]
终止	57,390,650 bp[1]
基因位置（小鼠）
染色体	小鼠2号染色体[2]
终止	84,813,976 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• heparin binding; • carbohydrate binding; • extracellular matrix structural constituent conferring compression resistance;
細胞組分	• 細胞外區域; • transport vesicle; • cytoplasmic vesicle; • 外排體; • ficolin-1-rich granule lumen; • collagen-containing extracellular matrix;
生物學過程	• defense response to bacterium; • immune system process; • defense response to nematode; • negative regulation of interleukin-10 production; • positive regulation of interleukin-4 production; • 免疫反应; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	5553
	19074
	ENSG00000186652
	ENSMUSG00000027073
	P13727
	Q61878
	NM_002728; NM_001243245; NM_001302926; NM_001302927
	NM_008920
	NP_001230174; NP_001289855; NP_001289856; NP_002719
	NP_032946
	維基數據

主要碱性蛋白（英語：，MBP），全称为嗜酸性粒细胞主要碱性蛋白（英語：），也称为蛋白多糖2（Proteoglycan 2，PRG2），是一种由人类基因PRG2编码的蛋白质[5]。

MBP在结构上类似于凝集素（糖结合蛋白），特别是与C-型凝集素在折叠上相似。但与C-型凝集素不同（C-型凝集素在钙的存在下会结合各种碳水化合物），MBP既不与钙结合也不与这些糖类结合，而是识别並結合硫酸乙酰肝素（heparan sulfate）。MBP的两种晶体结构已被测定。[6][7]

相互作用

主要碱性蛋白已知可与妊娠相关血浆蛋白A发生蛋白質交互作用。[8][9][10]

参考文献

GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. （原始内容存档于2008-11-02）.
PDB 1h8u; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR. . J. Biol. Chem. July 2001, 276 (28): 26197–26203. PMID 11319227. doi:10.1074/jbc.M100848200.
PDB 2brs; Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR. . Biochemistry. November 2005, 44 (43): 14152–14158. PMID 16245931. doi:10.1021/bi051112b.
Overgaard, M T; Haaning J; Boldt H B; Olsen I M; Laursen L S; Christiansen M; Gleich G J; Sottrup-Jensen L; Conover C A; Oxvig C. . J. Biol. Chem. (UNITED STATES). October 2000, 275 (40): 31128–31133. ISSN 0021-9258. PMID 10913121. doi:10.1074/jbc.M001384200.
Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C. . J. Biol. Chem. (United States). January 2003, 278 (4): 2106–2117. ISSN 0021-9258. PMID 12421832. doi:10.1074/jbc.M208777200.
Oxvig, C; Sand O; Kristensen T; Gleich G J; Sottrup-Jensen L. . J. Biol. Chem. (UNITED STATES). June 1993, 268 (17): 12243–6. ISSN 0021-9258. PMID 7685339.

外部链接

醫學主題詞表（MeSH）：Eosinophil+Major+Basic+Protein

延伸阅读

Vanhaesebroeck B, Alessi DR. . Biochem. J. 2000, 346 (3): 561–76. PMC 1220886 . PMID 10698680. doi:10.1042/0264-6021:3460561.
Yoshimatsu K, Ohya Y, Shikata Y, et al. . Mol. Immunol. 1992, 29 (4): 537–546. PMID 1565101. doi:10.1016/0161-5890(92)90012-M.
Barker RL, Loegering DA, Arakawa KC, et al. . Gene. 1990, 86 (2): 285–289. PMID 2323577. doi:10.1016/0378-1119(90)90292-Y.
Gabay JE, Scott RW, Campanelli D, et al. . Proc. Natl. Acad. Sci. U.S.A. 1989, 86 (14): 5610–5614. Bibcode:1989PNAS...86.5610G. PMC 297672 . PMID 2501794. doi:10.1073/pnas.86.14.5610.
Wasmoen TL, McKean DJ, Benirschke K, et al. . J. Exp. Med. 1990, 170 (6): 2051–2063. PMC 2189540 . PMID 2584934. doi:10.1084/jem.170.6.2051.
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Kristensen T, Oxvig C, Sand O, et al. . Biochemistry. 1994, 33 (6): 1592–1598. PMID 7508748. doi:10.1021/bi00172a040.
Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L. . Biochem. Mol. Biol. Int. 1994, 33 (2): 329–36. PMID 7524900.
Bonno M, Oxvig C, Kephart GM, et al. . Lab. Invest. 1994, 71 (4): 560–6. PMID 7526035.
Li MS, Sun L, Satoh T, et al. . Biochem. J. 1995, 305 (3): 921–7. PMC 1136346 . PMID 7531438.
Oxvig C, Haaning J, Kristensen L, et al. . J. Biol. Chem. 1995, 270 (23): 13645–13651. PMID 7539791. doi:10.1074/jbc.270.23.13645.
Oxvig C, Sand O, Kristensen T, et al. . J. Biol. Chem. 1993, 268 (17): 12243–6. PMID 7685339.
Levi-Schaffer F, Lacy P, Severs NJ, et al. . Blood. 1995, 85 (9): 2579–86. PMID 7727786.
Oxvig C, Gleich GJ, Sottrup-Jensen L. . FEBS Lett. 1994, 341 (2–3): 213–217. PMID 8137941. doi:10.1016/0014-5793(94)80459-1.
Shikata Y, Hayashi Y, Yoshimatsu K, et al. . Biochim. Biophys. Acta. 1993, 1163 (3): 243–9. PMID 8507662. doi:10.1016/0167-4838(93)90158-N.
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Delcommenne M, Tan C, Gray V, et al. . Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (19): 11211–11216. Bibcode:1998PNAS...9511211D. PMC 21621 . PMID 9736715. doi:10.1073/pnas.95.19.11211.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] . （原始内容存档于2008-11-02）.

[pmid11319227-6] PDB 1h8u; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR. . J. Biol. Chem. July 2001, 276 (28): 26197–26203. PMID 11319227. doi:10.1074/jbc.M100848200.

[pmid16245931-7] PDB 2brs; Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR. . Biochemistry. November 2005, 44 (43): 14152–14158. PMID 16245931. doi:10.1021/bi051112b.

[pmid10913121-8] Overgaard, M T; Haaning J; Boldt H B; Olsen I M; Laursen L S; Christiansen M; Gleich G J; Sottrup-Jensen L; Conover C A; Oxvig C. . J. Biol. Chem. (UNITED STATES). October 2000, 275 (40): 31128–31133. ISSN 0021-9258. PMID 10913121. doi:10.1074/jbc.M001384200.

[pmid12421832-9] Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C. . J. Biol. Chem. (United States). January 2003, 278 (4): 2106–2117. ISSN 0021-9258. PMID 12421832. doi:10.1074/jbc.M208777200.

[pmid7685339-10] Oxvig, C; Sand O; Kristensen T; Gleich G J; Sottrup-Jensen L. . J. Biol. Chem. (UNITED STATES). June 1993, 268 (17): 12243–6. ISSN 0021-9258. PMID 7685339.