克罗莫结构域

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要
PDB	1ak5, 1b3o, 1jcn, 1jr1, 1lrt, 1me7, 1me8, 1me9, 1meh, 1mei, 1mew, 1nf7, 1nfb, 1o50, 1pbj, 1pvm, 1pvn, 1vr9, 1vrd, 1xkf, 1y5h, 1yav, 1zfj, 2cu0, 2d4z, 2ef7, 2j9l, 2nyc, 2nye, 2o16, 2oox, 2oux, 2qh1, 2rc3, 2rif, 2rih, 2v8q, 2v92, 2v9j, 2yvx, 2yzi, 2yzq, 3ddj

克罗莫结构域
	多梳克罗莫结构域的结构[1]
鑑定
標誌	Chromodomain
Pfam	PF00385（旧版）
InterPro	IPR000953
SMART	SM00298
PROSITE	PS50013
SCOP	1pfb / SUPFAM
CDD	cd00024
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	結構概要
PDB	1ak5, 1b3o, 1jcn, 1jr1, 1lrt, 1me7, 1me8, 1me9, 1meh, 1mei, 1mew, 1nf7, 1nfb, 1o50, 1pbj, 1pvm, 1pvn, 1vr9, 1vrd, 1xkf, 1y5h, 1yav, 1zfj, 2cu0, 2d4z, 2ef7, 2j9l, 2nyc, 2nye, 2o16, 2oox, 2oux, 2qh1, 2rc3, 2rif, 2rih, 2v8q, 2v92, 2v9j, 2yvx, 2yzi, 2yzq, 3ddj

克罗莫结构域或染色質結構域（英語：，chromatin organization modifier[2]）是一种由40～50个氨基酸残基组成的蛋白质结构域，往往存在于那些与染色质重塑及操控有关的蛋白质里。此结构域不管在植物及动物之中都高度保守，且在许多基因组（如小鼠）中代表了较大数量的各种蛋白质。许多包含克罗莫结构域的基因有多种可变剪接亚型，有些亚型完全把克罗莫结构域当作内含子切除出去[3]。在哺乳动物中，包含克罗莫结构域的蛋白质主要负责涉及到染色质重塑及形成异染色质区域这两方面的基因调控[4]。包含克罗莫结构域的蛋白质亦会结合到甲基化组蛋白上[5][6]且存在于RNA诱导的转录沉默复合物中[7]。

另见

布罗莫结构域
克罗莫影结构域

参考文献

Min J, Zhang Y, Xu RM. . Genes Dev. August 2003, 17 (15): 1823–8. PMC 196225 . PMID 12897052. doi:10.1101/gad.269603.
S Messmer, A Franke, R Paro. . Genes Dev. July 1992, 6 (7): 1241–1254. PMID 1628830. doi:10.1101/gad.6.7.1241.
Tajul-Arifin, K; Teasdale, R; Ravasi, T; Humel, DA; Group, RIKEN GER; Members, GSL; Mattick, JS. . Genome Res. 2003, 13 (6B): 1416–1429. PMC 403676 . PMID 12819141. doi:10.1101/gr.1015703. 已忽略未知参数|author-separator= (帮助)
Jones, DO; Cowell, IG; Singh, PB. . Bioessays. 2000, 22 (2): 124–37. PMID 10655032. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. 已忽略未知参数|author-separator= (帮助)
Nielsen, PR; Nietlispach, D; Mott, HR; Callaghan, J; Bannister, A; Kouzarides, T; Murzin, AG; Murzina, NV; Laue, ED.; et al. . Nature. 2002, 416 (6876): 103–7. PMID 11882902. doi:10.1038/nature722. 已忽略未知参数|author-separator= (帮助)
Jacobs, SA; Khorasanizadeh, S. . Science. 2002, 295 (5562): 2080–3. PMID 11859155. doi:10.1126/science.1069473. 已忽略未知参数|author-separator= (帮助)
Verdel, A; Jia, S; Gerber, S; Sugiyama, T; Gygi, S; Grewal, S; Moazed, D. . Science. 2004, 303 (5658): 672–6. PMC 3244756 . PMID 14704433. doi:10.1126/science.1093686. 已忽略未知参数|author-separator= (帮助)

外部链接

Chromatin Remodeling: Chromodomains （页面存档备份，存于） at cellsignal.com （页面存档备份，存于）

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[pmid12897052-1] Min J, Zhang Y, Xu RM. . Genes Dev. August 2003, 17 (15): 1823–8. PMC 196225 . PMID 12897052. doi:10.1101/gad.269603.

[pmid1628830-2] S Messmer, A Franke, R Paro. . Genes Dev. July 1992, 6 (7): 1241–1254. PMID 1628830. doi:10.1101/gad.6.7.1241.

[Tajul-3] Tajul-Arifin, K; Teasdale, R; Ravasi, T; Humel, DA; Group, RIKEN GER; Members, GSL; Mattick, JS. . Genome Res. 2003, 13 (6B): 1416–1429. PMC 403676 . PMID 12819141. doi:10.1101/gr.1015703. 已忽略未知参数|author-separator= (帮助)

[Jones-4] Jones, DO; Cowell, IG; Singh, PB. . Bioessays. 2000, 22 (2): 124–37. PMID 10655032. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. 已忽略未知参数|author-separator= (帮助)

[Nielsen-5] Nielsen, PR; Nietlispach, D; Mott, HR; Callaghan, J; Bannister, A; Kouzarides, T; Murzin, AG; Murzina, NV; Laue, ED.; et al. . Nature. 2002, 416 (6876): 103–7. PMID 11882902. doi:10.1038/nature722. 已忽略未知参数|author-separator= (帮助)

[Jacobs-6] Jacobs, SA; Khorasanizadeh, S. . Science. 2002, 295 (5562): 2080–3. PMID 11859155. doi:10.1126/science.1069473. 已忽略未知参数|author-separator= (帮助)

[Verdel-7] Verdel, A; Jia, S; Gerber, S; Sugiyama, T; Gygi, S; Grewal, S; Moazed, D. . Science. 2004, 303 (5658): 672–6. PMC 3244756 . PMID 14704433. doi:10.1126/science.1093686. 已忽略未知参数|author-separator= (帮助)