十一烯酸睾酮

十一烯酸睾酮，缩写TUe，是一种雄激素/合成代谢类固醇药物和雄激素酯，已不再上市。[1][2][3]它是Durasteron和Triolandren的成分，这两种药物是长效的睾酮酯油溶液混合物，通过肌肉注射给药。[4][5][6][7]

十一烯酸睾酮
臨床資料
商品名Durasteron、Triolandren
其他名稱TUe、睾酮十一烯酸酯
给药途径静脉注射
藥物類別雄激素、合成代谢类固醇、雄激素酯
识别
  • [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undec-10-enoate
CAS号29430-26-0  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.045.099
化学
化学式C30H46O3
摩尔质量454.70 g·mol−1
3D模型（JSmol）
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCCCCCCCC=C)CCC4=CC(=O)CC[C@]34C
  • InChI=1S/C30H46O3/c1-4-5-6-7-8-9-10-11-12-28(32)33-27-16-15-25-24-14-13-22-21-23(31)17-19-29(22,2)26(24)18-20-30(25,27)3/h4,21,24-27H,1,5-20H2,2-3H3/t24-,25-,26-,27-,29-,30-/m0/s1
  • Key:PBFYIQCFOZXSKC-CNQKSJKFSA-N

参见

参考资料
  1. Shapiro S, Weinburg K, Freedman L. . The Journal of Organic Chemistry. 1956, 21 (11): 1300–1302. ISSN 0022-3263. doi:10.1021/jo01117a602.
  2. Gould D, Finckenor L, Hershberg EB, Cassidy J, Perlman PL. . Journal of the American Chemical Society. 1957, 79 (16): 4472–4475. ISSN 0002-7863. doi:10.1021/ja01573a061.
  3. US 2855341,Meier, R; A Wettstein & E Lang,「Testosterone compositions」,发表于1958-10-07,指定于Ciba pharmaceutical Products, Inc.
  4. Schuermann H, Doepfmer R. . Springer-Verlag. 1960: 260–. ISBN 978-3-642-94784-1.
  5. Ufer J. . Gruyter. 1960: 153. ISBN 9783111138770.
  6. Aakvaag A, Vogt JH. . Acta Endocrinologica. March 1969, 60 (3): 537–542. PMID 5395873. doi:10.1530/acta.0.0600537. Triolandren®, for intramuscular use, kindly supplied by Ciba, Basel, through Kobro 8c Co., Oslo, containing three different testosterone esters, in the following amounts of testosterone equivalents per ml oil: propionate 20 mg; valerate 80 mg; undecylenate 150 mg.
  7. Zachmann M, Prader A. . The Journal of Clinical Endocrinology and Metabolism. January 1970, 30 (1): 85–95. PMID 4311616. doi:10.1210/jcem-30-1-85. Triolandren, CIBA; 250 mg of this preparation contains 20 mg of testosterone propionate, 80 mg of testosterone-n-valerianate, and 150 mg of testosterone undecylenate—250 mg thus contains 173.8 mg of testosterone; the remaining 76.2 mg consists of the ester components [...]
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