周期蛋白依赖性激酶6

周期蛋白依赖性激酶6
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1BI7、1BI8、1BLX、1G3N、1JOW、1XO2、2EUF、2F2C、3NUP、3NUX、4AUA、4EZ5、4TTH
識別號
别名	CDK6；, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6
外部ID	OMIM：603368 MGI：1277162 HomoloGene：963 GeneCards：CDK6
相關疾病
	類風濕性關節炎、microcephaly 12, primary, autosomal recessive[1]
為以下藥物的標靶
	帕布昔利布、trilaciclib、帕布昔利布、截癌寧、at-7519、AZD5438、瑞博西利[2]
基因位置（人类）
染色体	7號染色體[3]
终止	92,836,573 bp[3]
基因位置（小鼠）
染色体	小鼠5号染色体[4]
终止	3,581,008 bp[4]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 轉移酶活性; • 蛋白激酶活性; • 核苷酸結合; • 細胞週期蛋白依賴性蛋白絲氨酸/蘇氨酸激酶活性; • 激酶活性; • 蛋白质丝氨酸/苏氨酸激酶活性; • 血浆蛋白结合; • ATP結合; • 細胞週期蛋白結合; • FBXO family protein binding;
細胞組分	• 細胞質; • 中心体; • cell projection; • 細胞週期蛋白依賴性蛋白激酶全酶複合物; • ruffle; • 微管组织中心; • 细胞骨架; • 细胞核; • 细胞质基质; • 核质; • cyclin D2-CDK6 complex;
生物學過程	• 细胞分化; • lateral ventricle development; • 磷酸化; • positive regulation of cell-matrix adhesion; • positive regulation of fibroblast proliferation; • dentate gyrus development; • regulation of erythrocyte differentiation; • astrocyte development; • negative regulation of cell differentiation; • response to virus; • negative regulation of cell cycle; • negative regulation of osteoblast differentiation; • generation of neurons; • 細胞分裂; • regulation of cell motility; • protein phosphorylation; • negative regulation of epithelial cell proliferation; • 基因調節; • 細胞週期; • type B pancreatic cell development; • negative regulation of myeloid cell differentiation; • negative regulation of cellular senescence; • gliogenesis; • negative regulation of cell population proliferation; • negative regulation of monocyte differentiation; • 訊息傳遞; • regulation of G2/M transition of mitotic cell cycle; • regulation of cell population proliferation; • cell dedifferentiation; • G1/S transition of mitotic cell cycle; • negative regulation of transcription by RNA polymerase II; • hematopoietic progenitor cell differentiation; • Notch信号通路; • positive regulation of gene expression; • 造血作用; • T cell differentiation in thymus; • hematopoietic stem cell differentiation; • regulation of hematopoietic stem cell differentiation; • negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	1021
	12571
	ENSG00000105810
	ENSMUSG00000040274
	Q00534
	Q64261
	NM_001145306; NM_001259
	NM_009873
	NP_001138778; NP_001250
	NP_034003
	維基數據

周期蛋白依赖性激酶6（英語：，CDK6）是一种由基因CDK6编码的激酶，由周期蛋白激活。具体来说，CDK6受周期蛋白D激活，受CDK抑制蛋白抑制。

CDK6属于周期蛋白依赖性激酶（CDK）家族，其中包括周期蛋白依赖性激酶4（CDK4）。

参考文献

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GRCh38: Ensembl release 89: ENSG00000105810 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040274 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

醫學主題詞表（MeSH）：Cyclin-Dependent+Kinase+6

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000105810 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000040274 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.