周期蛋白A1

Cyclin A1; 周期素A1
标识
代号	CCNA1
扩展标识	遗传学：604036 鼠基因：108042 同源基因：31203 ChEMBL: 3609 GeneCards: CCNA1 Gene
基因本体论描述
分子功能	· protein binding; · protein kinase binding;
细胞成分	· nucleoplasm; · cytosol; · microtubule cytoskeleton;
生物过程	· regulation of cyclin-dependent protein serine/threonine kinase activity; · G1/S transition of mitotic cell cycle; · regulation of transcription involved in G1/S phase of mitotic cell cycle; · G2/M transition of mitotic cell cycle; · mitotic cell cycle; · mitosis; · male meiosis I; · spermatogenesis; · cell division;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

周期蛋白A1（英語：，或译为周期素A1）是一个由人类基因 CCNA1 编码的蛋白质[1]。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中，现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1和Cdk2两种激酶相结合，但这两种激酶活性完全不相同，前者激酶活性表现于G2期，而后者激酶活性表现于S期，因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上，后者如：Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族[2]。

相互作用

周期蛋白A1能与E2F1[3]、CDC20[4]、视网膜母细胞瘤蛋白[3]、周期蛋白依赖性激酶2[1][5][6][7]、GPS2[8] MYBL2[6]和GNB2L1[8]发生相互作用。

参考文献

Yang R, Morosetti R, Koeffler HP. . Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.
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Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. . Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.
Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. . Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.
Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. . Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.
Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. . Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.
Brown, N R; Noble M E, Endicott J A, Johnson L N. . Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.
Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. . J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

延伸阅读

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[pmid9041194-1] Yang R, Morosetti R, Koeffler HP. . Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.

[entrez-2] .

[pmid10022926-3] Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. . Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.

[pmid10679238-4] Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. . Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.

[pmid8565853-5] Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. . Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.

[pmid11264176-6] Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. . Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.

[pmid10559988-7] Brown, N R; Noble M E, Endicott J A, Johnson L N. . Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.

[pmid15159402-8] Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. . J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.