E2F1

E2F transcription factor 1
	PDB rendering based on 2aze.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1H24, 1O9K, 2AZE
标识
代号	E2F1; E2F-1; RBAP1; RBBP3; RBP3
扩展标识	遗传学：189971 鼠基因：101941 同源基因：3828 ChEMBL: 4382 GeneCards: E2F1 Gene
基因本体论描述
分子功能	· core promoter binding; · DNA binding; · sequence-specific DNA binding transcription factor activity; · transcription corepressor activity; · protein binding; · transcription factor binding; · sequence-specific DNA binding;
细胞成分	· nucleus; · nucleoplasm; · cytoplasm; · Rb-E2F complex;
生物过程	· DNA damage checkpoint; · G1 phase of mitotic cell cycle; · G1/S transition of mitotic cell cycle; · G2 phase of mitotic cell cycle; · negative regulation of transcription from RNA polymerase II promoter; · mitotic cell cycle; · transcription, DNA-dependent; · regulation of transcription, DNA-dependent; · apoptotic process; · spermatogenesis; · cell proliferation; · positive regulation of gene expression; · forebrain development; · negative regulation of transcription, DNA-dependent; · positive regulation of transcription, DNA-dependent; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of fibroblast proliferation; · mRNA stabilization; · cellular response to fatty acid; · cellular response to hypoxia; · negative regulation of transcription involved in G1/S phase of mitotic cell cycle; · regulation of G1/S transition of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

转录因子E2F1是由人类E2F1基因编码出的蛋白质[1]。

该基因编码出的蛋白质是E2F转录因子家族中的成员。E2F家族在控制细胞周期及抑癌基因功能上起到重要作用，也是小DNA致癌病毒转化蛋白的靶点。E2F家族中的多个成员蛋白包含许多进化保守的结构域。这些结构域包括：DNA结合域、与受分化调控的转录因子蛋白（DP）之间相互作用的二聚化结构域、富含酸性氨基酸的转活化结构域以及位于转活化结构域中的抑癌蛋白关联结构域。该蛋白与其他两个成员E2F2及E2F3具有额外的周期蛋白结合结构域。该蛋白以细胞周期依赖性的模式优先与视网膜母细胞瘤蛋白pRB结合。它可以同时介导细胞增殖及p53-依赖/非依赖的细胞凋亡[2]。

转录

E2F1的启动子区有PAX8转录因子的结合序列，可促进E2F1的转录[3]。

相互作用

E2F1与下列蛋白具有相互作用：NCOA6[4]、视网膜母细胞瘤样蛋白1[5]、视网膜母细胞瘤蛋白[5][6][7][8][9][10][11]、GTF2H1[12]、SKP2[13] PURA,[14]、NPDC1[15]、Sp2转录因子[16]、Sp1转录因子[16][17][18]、CUL1[13] ARID3A,[19]、TOPBP1[20][21]、周期蛋白A1[22]、TP53BP1[8]、周期蛋白A2[23]、Sp4转录因子[16]、Sp3转录因子[16]、抗增殖蛋白[24][25][26][27]、NDN[11][28]、MDM4[29] TFDP1[10][19][30][31]及泛素C[32]。

另见

参考文献

Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. . Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9.
. （原始内容存档于2019-10-16）.
Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. . Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190.
Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. . Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867.
Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. . J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233 . PMID 8230483.
Nicolas, E; Ait-Si-Ali S, Trouche D. . Nucleic Acids Res. (England). August 2001, 29 (15): 3131–6. PMC 55834 . PMID 11470869. doi:10.1093/nar/29.15.3131.
Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M. . J. Biol. Chem. (United States). December 2002, 277 (52): 50860–6. ISSN 0021-9258. PMID 12397079. doi:10.1074/jbc.M203839200.
Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P. . EMBO J. (ENGLAND). October 1996, 15 (20): 5668–78. ISSN 0261-4189. PMC 452311 . PMID 8896460.
Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). July 2000, 97 (14): 7738–43. ISSN 0027-8424. PMC 16614 . PMID 10869426. doi:10.1073/pnas.130198397.
Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A. . Mol. Cell. Biol. (UNITED STATES). May 1995, 15 (5): 2536–46. ISSN 0270-7306. PMC 230484 . PMID 7739537.
Taniura, H; Taniguchi N, Hara M, Yoshikawa K. . J. Biol. Chem. (UNITED STATES). January 1998, 273 (2): 720–8. ISSN 0021-9258. PMID 9422723. doi:10.1074/jbc.273.2.720.
Vandel, L; Kouzarides T. . EMBO J. (ENGLAND). August 1999, 18 (15): 4280–91. ISSN 0261-4189. PMC 1171504 . PMID 10428966. doi:10.1093/emboj/18.15.4280.
Marti, A; Wirbelauer C, Scheffner M, Krek W. . Nat. Cell Biol. (ENGLAND). May 1999, 1 (1): 14–9. ISSN 1465-7392. PMID 10559858. doi:10.1038/8984.
Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. . Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011.
Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. . Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843.
Rotheneder, H; Geymayer S, Haidweger E. . J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213.
Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. . Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153 . PMID 8657142.
Karlseder, J; Rotheneder H, Wintersberger E. . Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152 . PMID 8657141.
Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. . Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163.
Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. . Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207 . PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003.
Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. . Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753.
Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. . Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.
Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. . Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381 . PMID 7969176.
Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. . Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148.
Fusaro, Gina; Dasgupta Piyali, Rastogi Shipra, Joshi Bharat, Chellappan Srikumar. . J. Biol. Chem. (United States). November 2003, 278 (48): 47853–61. ISSN 0021-9258. PMID 14500729. doi:10.1074/jbc.M305171200.
Wang, Sheng; Zhang Baohua, Faller Douglas V. . EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057 . PMID 12065415. doi:10.1093/emboj/cdf302.
Wang, S; Nath N, Fusaro G, Chellappan S. . Mol. Cell. Biol. (UNITED STATES). November 1999, 19 (11): 7447–60. ISSN 0270-7306. PMC 84738 . PMID 10523633.
Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. . J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200.
Strachan, Gordon D; Jordan-Sciutto Kelly L, Rallapalli Ravikumar, Tuan Rocky S, Hall David J. . J. Cell. Biochem. (United States). February 2003, 88 (3): 557–68. ISSN 0730-2312. PMID 12532331. doi:10.1002/jcb.10318.
Sardet, C; Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg R A. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). March 1995, 92 (6): 2403–7. ISSN 0027-8424. PMC 42492 . PMID 7892279. doi:10.1073/pnas.92.6.2403.
Helin, K; Wu C L, Fattaey A R, Lees J A, Dynlacht B D, Ngwu C, Harlow E. . Genes Dev. (UNITED STATES). October 1993, 7 (10): 1850–61. ISSN 0890-9369. PMID 8405995. doi:10.1101/gad.7.10.1850.
Zhou, Fangfang; Zhang Long, Wang Aijun, Song Bo, Gong Kai, Zhang Lihai, Hu Min, Zhang Xiufang, Zhao Nanming, Gong Yandao. . J. Biol. Chem. (United States). May 2008, 283 (21): 14506–15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200.

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.

深入阅读

Dupont E, Sansal I, Toru D; et al. . C. R. Seances Soc. Biol. Fil. 1997, 191 (1): 95–104. PMID 9181131.
Stevens C, La Thangue NB. . DNA Repair (Amst.). 2005, 3 (8-9): 1071–9. PMID 15279795. doi:10.1016/j.dnarep.2004.03.034.
Zhang Z, Wang H, Li M; et al. . Ann. N. Y. Acad. Sci. 2006, 1058 (1): 205–14. PMID 16394138. doi:10.1196/annals.1359.030.
Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G. . Mol. Carcinog. July 2009, 48 (12): 1149–58. PMID 19603422. doi:10.1002/mc.20569.

外部链接

E2F1引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[pmid8964493-1] Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. . Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9.

[2] . （原始内容存档于2019-10-16）.

[LiNyman2011-3] Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. . Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190.

[pmid14638867-4] Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. . Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867.

[pmid8230483-5] Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. . J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233 . PMID 8230483.

[pmid11470869-6] Nicolas, E; Ait-Si-Ali S, Trouche D. . Nucleic Acids Res. (England). August 2001, 29 (15): 3131–6. PMC 55834 . PMID 11470869. doi:10.1093/nar/29.15.3131.

[pmid12397079-7] Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M. . J. Biol. Chem. (United States). December 2002, 277 (52): 50860–6. ISSN 0021-9258. PMID 12397079. doi:10.1074/jbc.M203839200.

[pmid8896460-8] Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P. . EMBO J. (ENGLAND). October 1996, 15 (20): 5668–78. ISSN 0261-4189. PMC 452311 . PMID 8896460.

[pmid10869426-9] Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). July 2000, 97 (14): 7738–43. ISSN 0027-8424. PMC 16614 . PMID 10869426. doi:10.1073/pnas.130198397.

[pmid7739537-10] Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A. . Mol. Cell. Biol. (UNITED STATES). May 1995, 15 (5): 2536–46. ISSN 0270-7306. PMC 230484 . PMID 7739537.

[pmid9422723-11] Taniura, H; Taniguchi N, Hara M, Yoshikawa K. . J. Biol. Chem. (UNITED STATES). January 1998, 273 (2): 720–8. ISSN 0021-9258. PMID 9422723. doi:10.1074/jbc.273.2.720.

[pmid10428966-12] Vandel, L; Kouzarides T. . EMBO J. (ENGLAND). August 1999, 18 (15): 4280–91. ISSN 0261-4189. PMC 1171504 . PMID 10428966. doi:10.1093/emboj/18.15.4280.

[pmid10559858-13] Marti, A; Wirbelauer C, Scheffner M, Krek W. . Nat. Cell Biol. (ENGLAND). May 1999, 1 (1): 14–9. ISSN 1465-7392. PMID 10559858. doi:10.1038/8984.

[pmid10597240-14] Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. . Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011.

[pmid11042687-15] Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. . Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843.

[pmid10547281-16] Rotheneder, H; Geymayer S, Haidweger E. . J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213.

[pmid8657142-17] Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. . Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153 . PMID 8657142.

[pmid8657141-18] Karlseder, J; Rotheneder H, Wintersberger E. . Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152 . PMID 8657141.

[pmid9780002-19] Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. . Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163.

[pmid12697828-20] Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. . Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207 . PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003.

[pmid14576433-21] Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. . Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753.

[pmid10022926-22] Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. . Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.

[pmid7969176-23] Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. . Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381 . PMID 7969176.

[pmid14637159-24] Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. . Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148.

[pmid14500729-25] Fusaro, Gina; Dasgupta Piyali, Rastogi Shipra, Joshi Bharat, Chellappan Srikumar. . J. Biol. Chem. (United States). November 2003, 278 (48): 47853–61. ISSN 0021-9258. PMID 14500729. doi:10.1074/jbc.M305171200.

[pmid12065415-26] Wang, Sheng; Zhang Baohua, Faller Douglas V. . EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057 . PMID 12065415. doi:10.1093/emboj/cdf302.

[pmid10523633-27] Wang, S; Nath N, Fusaro G, Chellappan S. . Mol. Cell. Biol. (UNITED STATES). November 1999, 19 (11): 7447–60. ISSN 0270-7306. PMC 84738 . PMID 10523633.

[pmid14593116-28] Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. . J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200.

[pmid12532331-29] Strachan, Gordon D; Jordan-Sciutto Kelly L, Rallapalli Ravikumar, Tuan Rocky S, Hall David J. . J. Cell. Biochem. (United States). February 2003, 88 (3): 557–68. ISSN 0730-2312. PMID 12532331. doi:10.1002/jcb.10318.

[pmid7892279-30] Sardet, C; Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg R A. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). March 1995, 92 (6): 2403–7. ISSN 0027-8424. PMC 42492 . PMID 7892279. doi:10.1073/pnas.92.6.2403.

[pmid8405995-31] Helin, K; Wu C L, Fattaey A R, Lees J A, Dynlacht B D, Ngwu C, Harlow E. . Genes Dev. (UNITED STATES). October 1993, 7 (10): 1850–61. ISSN 0890-9369. PMID 8405995. doi:10.1101/gad.7.10.1850.

[pmid18367454-32] Zhou, Fangfang; Zhang Long, Wang Aijun, Song Bo, Gong Kai, Zhang Lihai, Hu Min, Zhang Xiufang, Zhao Nanming, Gong Yandao. . J. Biol. Chem. (United States). May 2008, 283 (21): 14506–15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200.