塞来昔布

塞来昔布英語:),商品名希樂葆西乐葆,是一种选择性COX-2抑制剂,属磺酰胺非類固醇消炎止痛藥(NSAID)类[1], 用于治疗骨关节炎类风湿性关节炎急性疼痛、痛经[2],以及减少家族性腺瘤性息肉病患者的结肠和直肠息肉数量。

塞来昔布
Skeletal formula of celecoxib
Space-filling model of celecoxib
臨床資料
商品名Celebrex
AHFS/Drugs.comMonograph
MedlinePlusa699022
核准狀況
懷孕分級
给药途径Oral
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度40%
血漿蛋白結合率97% (mainly to serum albumin)
药物代谢Hepatic (mainly CYP2C9)
生物半衰期~11 h
排泄途徑Renal 27%, faecal 57%
识别
  • 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
CAS号169590-42-5  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.211.644
化学
化学式C17H14F3N3O2S
摩尔质量381.373 g/mol
3D模型(JSmol
  • O=S(=O)(c3ccc(n1nc(cc1c2ccc(cc2)C)C(F)(F)F)cc3)N
  • InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) checkY
  • Key:RZEKVGVHFLEQIL-UHFFFAOYSA-N checkY

参考

  1. . Drugs.com. American Society of Health-System Pharmacists. 11 November 2019 [5 May 2020]. (原始内容存档于20 May 2019).
  2. 希樂葆膠囊 页面存档备份,存于 輝瑞大藥廠.
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