异炔诺酮

异炔诺酮（英語： 或 英語：，商品名：Enovid等）是一种黄体制剂药物，过去被用于口服避孕药以及治疗一些妇科疾病，但现在已不再使用[2][6][7][8]。异炔诺酮和炔诺酮的不同之处在于双键位于5(10)号位而非4(5)号位。

异炔诺酮
臨床資料
商品名Enovid (with mestranol), others
其他名稱Norethynodrel; Noretinodrel Norethinodrel; NYD; SC-4642; NSC-15432; 5(10)-Norethisterone; 17α-Ethinyl-19-nor-5(10)-testosterone; 17α-Ethynyl-δ5(10)-19-nortestosterone; 17α-Ethynylestr-5(10)-en-17β-ol-3-one; 19-Nor-17α-pregn-5(10)-en-20-yn-17β-ol-3-one
给药途径口服给药
藥物類別Progestin; Progestogen; Estrogen
ATC碼
藥物動力學數據
血漿蛋白結合率Noretynodrel: to albumin and not to SHBG or CBG[1]
药物代谢Liver, intestines (hydroxylation, isomerization, conjugation)[1][2]
代謝產物• 3α-Hydroxynoretynodrel[3]
• 3β-Hydroxynoretynodrel[3]
• Norethisterone[3][1][2]
• Ethinylestradiol[2][4]• Conjugates[2]
生物半衰期Very short (< 30 minutes)[5]
排泄途徑Breast milk: 1%[6]
识别
  • (8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
CAS号68-23-5  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.620
化学
化学式C20H26O2
摩尔质量298.419 g/mol
3D模型（JSmol）
  • O=C4CCC\1=C(\CC[C@@H]2[C@@H]/1CC[C@]3([C@H]2CC[C@]3(C#C)O)C)C4
  • InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,16-18,22H,4-12H2,2H3/t16-,17-,18+,19+,20+/m1/s1 checkY
  • Key:ICTXHFFSOAJUMG-SLHNCBLASA-N checkY

参考文献
  1. Kuhl H. . Maturitas. September 1990, 12 (3): 171–97. PMID 2170822. doi:10.1016/0378-5122(90)90003-O.
  2. Kuhl H. (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63 [2019-06-30]. PMID 16112947. doi:10.1080/13697130500148875. （原始内容存档 (PDF)于2016-08-22）.
  3. Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. . J. Steroid Biochem. Mol. Biol. 2012, 129 (3–5): 139–44. PMC 3303946 可免费查阅. PMID 22210085. doi:10.1016/j.jsbmb.2011.12.002.
  4. Kuhl H. (PDF). J Reproduktionsmed Endokrinol. 2011, 8 (1): 157–177 [2019-07-10]. （原始内容存档 (PDF)于2016-10-11）.
  5. Hammerstein J. . Am. J. Obstet. Gynecol. 1990, 163 (6 Pt 2): 2198–203. PMID 2256526.
  6. Sweetman, Sean C. (编). . 36th. London: Pharmaceutical Press. 2009: 2120–2121. ISBN 978-0-85369-840-1.
  7. Jucker. . Birkhäuser. 21 December 2013: 85–88 [2019-06-30]. ISBN 978-3-0348-7065-8. （原始内容存档于2021-03-14）.
  8. Lara Marks. . Yale University Press. 2010: 74–75. ISBN 978-0-300-16791-7.
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