普罗替林

普罗替林英語:,商品名Vivactil),分子式C19H21N,是一种仲胺三环类抗抑郁药(TCA)。

普罗替林
臨床資料
商品名Vivactyl, others
其他名稱Amimethyline; Protriptyline hydrochloride; MK-240
AHFS/Drugs.comMonograph
MedlinePlusa604025
给药途径口服
ATC碼
法律規範狀態
法律規範
  • 处方药(-only)
藥物動力學數據
生物利用度77–93%[1]
血漿蛋白結合率92%[1]
药物代谢Hepatic
生物半衰期54–92小时
排泄途徑Urine: 50%[1]
Feces: minor[1]
识别
  • 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
CAS号438-60-8  checkY
1225-55-4(盐酸盐)
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.474
化学
化学式C19H21N
摩尔质量263.38 g·mol−1
3D模型(JSmol
  • c3cc2c(\C=C/c1c(cccc1)C2CCCNC)cc3
  • InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3 checkY
  • Key:BWPIARFWQZKAIA-UHFFFAOYSA-N checkY

合成

普罗替林可由5H-二苯并[a,d]环庚烯、丁基锂3-氯丙醇为原料反应制得。[2]

参考资料

  1. Lemke TL, Williams DA. . Lippincott Williams & Wilkins. 24 January 2012: 588–. ISBN 978-1-60913-345-0.
  2. Nampalli, Satyam S.; Patel, Brijesh; Tharial, Peter Xavier; Kovi, Ravishanker. Process for a simple, cost-effective preparation of 5h-dibenzo[a,d] cycloheptene derivatives. US20080139848.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.