比托特罗

**比托特罗**
臨床資料
AHFS/Drugs.com	Micromedex详细消费者药物信息
MedlinePlus	a601236
ATC碼	R03AC17 (WHO) ;
识别
	IUPAC命名法 (RS)-[4-(1-Hydroxy-2-tert-butylamino-ethyl)-2-(4-methylbenzoyl)oxy-phenyl] 4-methylbenzoate; ;
CAS号	30392-40-6; 30392-41-7
PubChem CID	35330;
DrugBank	DB00901;
ChemSpider	32525;
UNII	9KY0QXD6LI; mesylate: 4E53T3611U ;
ChEMBL	ChEMBL1201295 ;
CompTox Dashboard (EPA)	DTXSID1022683 ;
化学
化学式	C28H31NO5
摩尔质量	461.56 g·mol−1
3D模型（JSmol）	交互式图像;
手性	外消旋混合物
	SMILES O=C(Oc2cc(ccc2OC(=O)c1ccc(cc1)C)C(O)CNC(C)(C)C)c3ccc(cc3)C;

比托特罗（INN：bitolterol）是一种短效β2肾上腺素受体激动剂，用于缓解哮喘[1][2]和慢性阻塞性肺病等疾病的支气管痉挛。[3][4][5]在这些疾病中，负责将空气输送到肺部的气道（支气管及其分支）会变窄。支气管内的肌肉痉挛和炎症加剧了这种变窄。比托特罗通过放松持续存在于支气管和支气管细支周围的平滑肌，有助于空气顺畅通过。

可尔特罗

比托特罗是可尔特罗的前药。[6][7]它起效迅速（2至5分钟），可持续长达6至8小时。[8]该药单独或与茶碱合用，不显示心脏毒性作用。[9]

美国食品和药物管理局于1984年12月批准了比托特罗。该药物于2001年被Élan制药从市场上撤回。

参考资料

Nathan RA, Bodman SF, Storms WW, Mingo TS. . Annals of Allergy. June 1986, 56 (6): 494–499. PMID 3717716.
Nathan RA, Bernstein IL, Bronsky EA, Bush RK, Chervinsky P, Condemi JJ, et al. . The Journal of Allergy and Clinical Immunology. May 1987, 79 (5): 822–829. PMID 3571773. doi:10.1016/0091-6749(87)90216-8 .
Friedel HA, Brogden RN. . Drugs. January 1988, 35 (1): 22–41. PMID 3278878. S2CID 218471864. doi:10.2165/00003495-198835010-00002. （原始内容存档于2012-12-23）.
. The American Psychologist. January 1979, 34 (1): 69–79. PMID 396832. doi:10.1037/h0078247.
Petty TL, Scoggin CH, Rollins DR, Repsher LH. . Chest. September 1984, 86 (3): 404–408. PMID 6380974. doi:10.1378/chest.86.3.404.
Walker SB, Kradjan WA, Bierman CW. . Pharmacotherapy. 6 May 1985, 5 (3): 127–137. PMID 3895171. S2CID 29431526. doi:10.1002/j.1875-9114.1985.tb03410.x.
. Chemical Entities of Biological Interest. Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. [27 March 2016].
Kass I, Mingo TS. . Chest. August 1980, 78 (2): 283–287. PMID 6995040. doi:10.1378/chest.78.2.283.
Kemp JP, Chervinsky P, Orgel HA, Meltzer EO, Noyes JH, Mingo TS. . The Journal of Allergy and Clinical Immunology. January 1984, 73 (1 Pt 1): 32–43. PMID 6693665. doi:10.1016/0091-6749(84)90481-0 .

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[pmid3717716-1] Nathan RA, Bodman SF, Storms WW, Mingo TS. . Annals of Allergy. June 1986, 56 (6): 494–499. PMID 3717716.

[pmid3571773-2] Nathan RA, Bernstein IL, Bronsky EA, Bush RK, Chervinsky P, Condemi JJ, et al. . The Journal of Allergy and Clinical Immunology. May 1987, 79 (5): 822–829. PMID 3571773. doi:10.1016/0091-6749(87)90216-8 .

[3] Friedel HA, Brogden RN. . Drugs. January 1988, 35 (1): 22–41. PMID 3278878. S2CID 218471864. doi:10.2165/00003495-198835010-00002. （原始内容存档于2012-12-23）.

[Anderson-1979-4] . The American Psychologist. January 1979, 34 (1): 69–79. PMID 396832. doi:10.1037/h0078247.

[Petty-1984-5] Petty TL, Scoggin CH, Rollins DR, Repsher LH. . Chest. September 1984, 86 (3): 404–408. PMID 6380974. doi:10.1378/chest.86.3.404.

[6] Walker SB, Kradjan WA, Bierman CW. . Pharmacotherapy. 6 May 1985, 5 (3): 127–137. PMID 3895171. S2CID 29431526. doi:10.1002/j.1875-9114.1985.tb03410.x.

[7] . Chemical Entities of Biological Interest. Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. [27 March 2016].

[pmid6995040-8] Kass I, Mingo TS. . Chest. August 1980, 78 (2): 283–287. PMID 6995040. doi:10.1378/chest.78.2.283.

[pmid6693665-9] Kemp JP, Chervinsky P, Orgel HA, Meltzer EO, Noyes JH, Mingo TS. . The Journal of Allergy and Clinical Immunology. January 1984, 73 (1 Pt 1): 32–43. PMID 6693665. doi:10.1016/0091-6749(84)90481-0 .