氢吗啡酮
氢吗啡酮(英語:,也称为二氢吗啡酮,dihydromorphinone,商品名:Dilaudid)是一种含氮有机化合物,化学式C17H19NO3,是一种用于缓解中度至重度疼痛的吗啡喃類阿片药物[5]。
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| 臨床資料 | |
|---|---|
| 商品名 | Dilaudid, Palladone, others |
| 其他名稱 | Dihydromorphinone |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682013 |
| 核准狀況 | |
| 懷孕分級 | |
| 依賴性 | High[2] |
| 成癮性 | High[3] |
| 给药途径 | By mouth, intramuscular, intravenous, subcutaneous |
| 藥物類別 | Opioid |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 藥物動力學數據 | |
| 生物利用度 | By mouth: 30–35%, Intranasal: 52–58%,[4] IV/IM: 100% |
| 血漿蛋白結合率 | 20% |
| 药物代谢 | 肝 |
| 藥效起始時間 | 15-30分钟[5] |
| 生物半衰期 | 2–3 hours[6] |
| 作用時間 | 4 to 5 hrs[5] |
| 排泄途徑 | Kidney |
| 识别 | |
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| CAS号 | 466-99-9 |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.006.713 |
| 化学 | |
| 化学式 | C17H19NO3 |
| 摩尔质量 | 285.34 g·mol−1 |
| 3D模型(JSmol) | |
| 水溶性 | HCl salt: 333 |
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参考文献
- . Drugs.com. 19 November 2019 [16 May 2020].
- Bonewit-West K, Hunt SA, Applegate E. . Elsevier Health Sciences. 2012: 571. ISBN 9781455701506 (英语).
- Bonewit-West K, Hunt SA, Applegate E. . Elsevier Health Sciences. 2012: 571 [20 August 2019]. ISBN 9781455701506. (原始内容存档于10 January 2023).
- Coda BA, Rudy AC, Archer SM, Wermeling DP. . Anesthesia and Analgesia. July 2003, 97 (1): 117–23, table of contents. CiteSeerX 10.1.1.551.6509
. PMID 12818953. S2CID 22694749. doi:10.1213/01.ANE.0000066311.40978.4F. - . Drugs.com. American Society of Health-System Pharmacists. [15 April 2019] (英语).
- Vallner JJ, Stewart JT, Kotzan JA, Kirsten EB, Honigberg IL. . Journal of Clinical Pharmacology. April 1981, 21 (4): 152–156. PMID 6165742. S2CID 29864565. doi:10.1002/j.1552-4604.1981.tb05693.x.
外部链接
- Article discussing withdrawal of extended-release hydromorphone from the U.S. market
- Dihydromorphinones from morphine & analogues
- United States DEA's perspective, including statistics on manufacture and prescription levels from 1998 to 2006
- "When is a pain doctor a drug pusher?", The New York Times, 17 June 2007
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