甲状腺激素α受体

甲状腺激素α受体
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1NAV、2H77、2H79、3HZF、3ILZ、3JZB、4LNW、4LNX
識別號
别名	THRA；, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
外部ID	OMIM：190120 MGI：98742 HomoloGene：37747 GeneCards：THRA
相關疾病
	congenital nongoitrous hypothryoidism 6[1]
為以下藥物的標靶
	反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲狀腺素鈉[2]
基因位置（人类）
染色体	17號染色體[3]
终止	40,093,867 bp[3]
基因位置（小鼠）
染色体	小鼠11号染色体[4]
终止	98,659,832 bp[4]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• transcription cis-regulatory region binding; • 血浆蛋白结合; • single-stranded RNA binding; • 鋅離子結合; • chromatin DNA binding; • nuclear receptor activity; • steroid receptor RNA activator RNA binding; • 转录因子结合; • TBP-class protein binding; • steroid hormone receptor activity; • DNA结合; • protein domain specific binding; • sequence-specific DNA binding; • 金屬離子結合; • DNA结合转录因子活性; • thyroid hormone binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 大分子复合物结合; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • nuclear receptor coactivator activity; • signaling receptor activity;
細胞組分	• 細胞質; • 核质; • 细胞核; • 细胞质基质; • RNA polymerase II transcription regulator complex;
生物學過程	• regulation of transcription by RNA polymerase II; • response to cold; • cytoplasmic sequestering of transcription factor; • hormone-mediated signaling pathway; • regulation of thyroid hormone mediated signaling pathway; • 甲状旁腺的发生; • regulation of transcription, DNA-templated; • 成骨作用; • female courtship behavior; • cartilage condensation; • negative regulation of RNA polymerase II transcription preinitiation complex assembly; • type I pneumocyte differentiation; • transcription, DNA-templated; • steroid hormone mediated signaling pathway; • transcription by RNA polymerase II; • regulation of lipid catabolic process; • regulation of heart contraction; • animal organ morphogenesis; • positive regulation of female receptivity; • 学习和记忆; • regulation of myeloid cell apoptotic process; • positive regulation of transcription by RNA polymerase II; • transcription initiation from RNA polymerase II promoter; • erythrocyte differentiation; • negative regulation of DNA-templated transcription, initiation; • positive regulation of myotube differentiation; • negative regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • negative regulation of transcription by RNA polymerase II; • thyroid hormone mediated signaling pathway; • multicellular organism development; • brain development; • 细胞分化; • response to lipid; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	7067
	21833
	ENSG00000126351
	ENSMUSG00000058756
	P10827
	P63058
	NM_199334; NM_001190918; NM_001190919; NM_003250
	NM_178060; NM_001313983
	NP_001177847; NP_001177848; NP_003241; NP_955366
	NP_001300912; NP_835161
	維基數據

甲状腺激素α受体（THR-α，TR-α），也称：核受体家族1, A组, 成员1 (NR1A1)，是一类核受体蛋白，在人类中由THR-α基因编码。[7][8][9]

功能

该基因编码的蛋白质为三碘甲腺原氨酸的核激素受体。它是甲状腺激素多种受体之一，已被证明可以调节甲状腺激素的生物活性, 小鼠敲除实验表明不同的受体虽然具有一定程度的冗余，但可能介导甲状腺激素的不同功能。[7]

病理学作用

THRA基因突变可能导致甲状腺功能减退症, 一种先天性甲状腺机能低下症亚型。

基因相互作用

甲状腺激素受体 α 已被证明与以下存在基因相互作用：

COPS2,[10]
EP300,[11]
ITGB3BP,[12][13]
MED1,[14]
MED6,[15]
MED12,[15]
MED16,[15]
MEF2A,[11]
NCOA6,[16][17]
TRIP11,[18]
UBC.[19]

参考文献

.
.
GRCh38: Ensembl release 89: ENSG00000126351 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000058756 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
.
Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B. . The EMBO Journal. Jan 1984, 3 (1): 159–63. PMC 557313 . PMID 6323162. doi:10.1002/j.1460-2075.1984.tb01777.x.
Dayton AI, Selden JR, Laws G, Dorney DJ, Finan J, Tripputi P, Emanuel BS, Rovera G, Nowell PC, Croce CM. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1984, 81 (14): 4495–9. Bibcode:1984PNAS...81.4495D. PMC 345617 . PMID 6589608. doi:10.1073/pnas.81.14.4495 .
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A. . Molecular and Cellular Biology. May 1999, 19 (5): 3383–94. PMC 84131 . PMID 10207062. doi:10.1128/mcb.19.5.3383.
De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G. . The Biochemical Journal. Feb 2003, 369 (Pt 3): 477–84. PMC 1223100 . PMID 12371907. doi:10.1042/BJ20020057.
Li D, Wang F, Samuels HH. . Molecular and Cellular Biology. Dec 2001, 21 (24): 8371–84. PMC 100002 . PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.
Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH. . Molecular and Cellular Biology. Oct 1999, 19 (10): 7191–202. PMC 84712 . PMID 10490654. doi:10.1128/mcb.19.10.7191.
Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1998, 95 (14): 7939–44. Bibcode:1998PNAS...95.7939Y. PMC 20908 . PMID 9653119. doi:10.1073/pnas.95.14.7939 .
Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG. . Molecular Cell. Mar 1999, 3 (3): 361–70. PMID 10198638. doi:10.1016/S1097-2765(00)80463-3 .
Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW. . The Journal of Biological Chemistry. Nov 1999, 274 (48): 34283–93. PMID 10567404. doi:10.1074/jbc.274.48.34283 .
Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW. . Molecular Endocrinology. Jun 2000, 14 (6): 915–25. PMID 10847592. doi:10.1210/mend.14.6.0471 .
Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH. . Proceedings of the National Academy of Sciences of the United States of America. Aug 1997, 94 (17): 9040–5. Bibcode:1997PNAS...94.9040C. PMC 23019 . PMID 9256431. doi:10.1073/pnas.94.17.9040 .
Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X. . Proteomics. Jul 2008, 8 (14): 2885–96. PMID 18655026. S2CID 25586938. doi:10.1002/pmic.200700887.

扩展阅读

Forrest D, Reh TA, Rüsch A. . Current Opinion in Neurobiology. Feb 2002, 12 (1): 49–56. PMID 11861164. S2CID 2884828. doi:10.1016/S0959-4388(02)00289-1.
Sakurai A, Bell GI, DeGroot LJ. . Human Molecular Genetics. Oct 1992, 1 (7): 553. PMID 1307263. doi:10.1093/hmg/1.7.553-a.
Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA. . Molecular Endocrinology. Sep 1992, 6 (9): 1468–78. PMID 1331778. S2CID 24291055. doi:10.1210/mend.6.9.1331778 .
Schmidt ED, Schmidt ED, van der Gaag R, Ganpat R, Broersma L, de Boer PA, Moorman AF, Lamers WH, Wiersinga WM, Koornneef L. . The Journal of Endocrinology. Apr 1992, 133 (1): 67–74. PMID 1517709. doi:10.1677/joe.0.1330067.
Yen PM, Sunday ME, Darling DS, Chin WW. . Endocrinology. Mar 1992, 130 (3): 1539–46. PMID 1537303. doi:10.1210/endo.130.3.1537303.
Laudet V, Begue A, Henry-Duthoit C, Joubel A, Martin P, Stehelin D, Saule S. . Nucleic Acids Research. Mar 1991, 19 (5): 1105–12. PMC 333788 . PMID 1850510. doi:10.1093/nar/19.5.1105.
Nakai A, Sakurai A, Bell GI, DeGroot LJ. . Molecular Endocrinology. Nov 1988, 2 (11): 1087–92. PMID 2464749. doi:10.1210/mend-2-11-1087 .
Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, Yamamoto T. . Cell. Apr 1989, 57 (1): 31–9. PMID 2539258. S2CID 19135678. doi:10.1016/0092-8674(89)90169-4.
Sakurai A, Nakai A, DeGroot LJ. . Molecular Endocrinology. Feb 1989, 3 (2): 392–9. PMID 2710139. doi:10.1210/mend-3-2-392 .
Sap J, Muñoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennström B. . Nature. 1987, 324 (6098): 635–40. PMID 2879242. S2CID 4353175. doi:10.1038/324635a0.
Nakai A, Seino S, Sakurai A, Szilak I, Bell GI, DeGroot LJ. . Proceedings of the National Academy of Sciences of the United States of America. Apr 1988, 85 (8): 2781–5. Bibcode:1988PNAS...85.2781N. PMC 280083 . PMID 3357890. doi:10.1073/pnas.85.8.2781 .
Mitelman F, Manolov G, Manolova Y, Billström R, Heim S, Kristoffersson U, Mandahl N, Ferro MT, San Roman C. . Cancer Genetics and Cytogenetics. Jun 1986, 22 (2): 95–8. PMID 3458521. doi:10.1016/0165-4608(86)90168-8.
Benbrook D, Pfahl M. . Science. Nov 1987, 238 (4828): 788–91. Bibcode:1987Sci...238..788B. PMID 3672126. doi:10.1126/science.3672126.
Pfahl M, Benbrook D. . Nucleic Acids Research. Nov 1987, 15 (22): 9613. PMC 306505 . PMID 3684612. doi:10.1093/nar/15.22.9613.
Chen JD, Evans RM. . Nature. Oct 1995, 377 (6548): 454–7. Bibcode:1995Natur.377..454C. PMID 7566127. S2CID 4361329. doi:10.1038/377454a0.
Desai-Yajnik V, Hadzic E, Modlinger P, Malhotra S, Gechlik G, Samuels HH. . Journal of Virology. Aug 1995, 69 (8): 5103–12. PMC 189328 . PMID 7609079. doi:10.1128/JVI.69.8.5103-5112.1995.
Lee JW, Choi HS, Gyuris J, Brent R, Moore DD. . Molecular Endocrinology. Feb 1995, 9 (2): 243–54. PMID 7776974. doi:10.1210/mend.9.2.7776974 .
Desai-Yajnik V, Samuels HH. . Transactions of the Association of American Physicians. 1994, 106: 13–32. PMID 8036737.

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000126351 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000058756 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-7] .

[pmid6323162-8] Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B. . The EMBO Journal. Jan 1984, 3 (1): 159–63. PMC 557313 . PMID 6323162. doi:10.1002/j.1460-2075.1984.tb01777.x.

[pmid6589608-9] Dayton AI, Selden JR, Laws G, Dorney DJ, Finan J, Tripputi P, Emanuel BS, Rovera G, Nowell PC, Croce CM. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1984, 81 (14): 4495–9. Bibcode:1984PNAS...81.4495D. PMC 345617 . PMID 6589608. doi:10.1073/pnas.81.14.4495 .

[pmid10207062-10] Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A. . Molecular and Cellular Biology. May 1999, 19 (5): 3383–94. PMC 84131 . PMID 10207062. doi:10.1128/mcb.19.5.3383.

[pmid12371907-11] De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G. . The Biochemical Journal. Feb 2003, 369 (Pt 3): 477–84. PMC 1223100 . PMID 12371907. doi:10.1042/BJ20020057.

[pmid11713274-12] Li D, Wang F, Samuels HH. . Molecular and Cellular Biology. Dec 2001, 21 (24): 8371–84. PMC 100002 . PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.

[pmid10490654-13] Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH. . Molecular and Cellular Biology. Oct 1999, 19 (10): 7191–202. PMC 84712 . PMID 10490654. doi:10.1128/mcb.19.10.7191.

[pmid9653119-14] Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG. . Proceedings of the National Academy of Sciences of the United States of America. Jul 1998, 95 (14): 7939–44. Bibcode:1998PNAS...95.7939Y. PMC 20908 . PMID 9653119. doi:10.1073/pnas.95.14.7939 .

[pmid10198638-15] Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG. . Molecular Cell. Mar 1999, 3 (3): 361–70. PMID 10198638. doi:10.1016/S1097-2765(00)80463-3 .

[pmid10567404-16] Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW. . The Journal of Biological Chemistry. Nov 1999, 274 (48): 34283–93. PMID 10567404. doi:10.1074/jbc.274.48.34283 .

[pmid10847592-17] Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW. . Molecular Endocrinology. Jun 2000, 14 (6): 915–25. PMID 10847592. doi:10.1210/mend.14.6.0471 .

[pmid9256431-18] Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH. . Proceedings of the National Academy of Sciences of the United States of America. Aug 1997, 94 (17): 9040–5. Bibcode:1997PNAS...94.9040C. PMC 23019 . PMID 9256431. doi:10.1073/pnas.94.17.9040 .

[pmid18655026-19] Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X. . Proteomics. Jul 2008, 8 (14): 2885–96. PMID 18655026. S2CID 25586938. doi:10.1002/pmic.200700887.