痛觉过敏

痛觉过敏是一种对过度敏感的异常状态,原因可能是伤害感受器末梢神经受损,其中起到关键作用的化学物质为前列腺素E和F[1]鸭嘴兽[2]、长期服用鸦片类药物[3]都会造成痛觉过敏。依照痛感发生部位的不同,它可分为原发性痛觉过敏和继发性痛觉过敏两种。

神经性疼痛触模痛等神经障碍引发的疼痛一样,痛觉过敏可以通过SSRI、三环抗抑郁药[4][5]非甾体类抗炎药[6]糖皮质激素[7]加巴喷丁[8]普瑞巴林[9]NMDA受体拮抗剂[10][11][12] 来治疗。换用非典型鸦片类药物如曲马朵也有利于减缓病情[13]

参考文献

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