类固醇生成因子1

类固醇生成因子1（英語：，缩写SF-1）是一种参与性別決定的转录因子，涉及生殖腺与肾上腺[6]。这一蛋白由NR5A1基因编码，属于核受体超家族，位于9号染色体长臂段的位置33.3。SF-1最初发现于其能调节CYP450类固醇羟化酶的表达，因而得名，之后又发现了参与调控许多相关基因[7]。

類固醇生成因子
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1YOW、​1ZDT、​4QJR、​4QK4
識別號
别名	NR5A1；, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, nuclear receptor subfamily 5 group A member 1, SRXX4
外部ID	OMIM：184757 MGI：1346833 HomoloGene：3638 GeneCards：NR5A1
相關疾病
卵巢早衰、​male infertility with azoospermia or oligozoospermia due to single gene mutation[1]
基因位置（人类） 染色体 9號染色體[2] 基因座 9q33.3 起始 124,481,236 bp[2] 终止 124,507,420 bp[2]
基因位置（小鼠） 染色体 小鼠2号染色体[3] 基因座 2 B|2 24.42 cM 起始 38,582,668 bp[3] 终止 38,604,554 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • 血浆蛋白结合 • 鋅離子結合 • lipid binding • double-stranded DNA binding • 酶结合 • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • steroid hormone receptor activity • 转录共激活因子活性 • phospholipid binding • 金屬離子結合 • DNA结合转录因子活性 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA结合 • chromatin binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • nuclear receptor activity • sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription cis-regulatory region binding 細胞組分 • 核质 • RNA polymerase II transcription regulator complex • 细胞核 生物學過程 • regulation of transcription by RNA polymerase II • positive regulation of transcription, DNA-templated • regulation of steroid biosynthetic process • hormone metabolic process • luteinization • reproductive process • primary sex determination • 组织发生 • multicellular organism aging • 细胞分化 • maintenance of protein location in nucleus • regulation of transcription, DNA-templated • adrenal gland development • transcription, DNA-templated • steroid hormone mediated signaling pathway • cell-cell signaling • transcription by RNA polymerase II • negative regulation of female gonad development • transcription initiation from RNA polymerase II promoter • positive regulation of male gonad development • intracellular receptor signaling pathway • positive regulation of transcription by RNA polymerase II • 性别决定系统 • male gonad development • female gonad development • positive regulation of gene expression • hormone-mediated signaling pathway • calcineurin-mediated signaling • response to gonadotropin-releasing hormone • male sex determination Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	2516	26423
Ensembl	ENSG00000136931	ENSMUSG00000026751
UniProt	Q13285	P33242
mRNA​序列	NM_004959	NM_139051 ​NM_001316687
蛋白序列	NP_004950 NP_004950.2	NP_001303616 ​NP_620639
基因位置​（UCSC）	Chr 9: 124.48 – 124.51 Mb	Chr 2: 38.58 – 38.6 Mb
PubMed​查找	[4]	[5]
維基數據