组氨酸脱羧酶
组氨酸脱羧酶（英語：，HDC）是一种以如下方式在维生素B6的帮助下催化从組氨酸生成組織胺的反应的酶：[1][2][3]
| 组氨酸脱羧酶 | |||||||
|---|---|---|---|---|---|---|---|
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| 在组氨酸脱羧酶作用下从組氨酸到組織胺的转化 | |||||||
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| 识别码 | |||||||
| EC編號 | 4.1.1.22 | ||||||
| CAS号 | 9024-61-7 | ||||||
| 数据库 | |||||||
| IntEnz | IntEnz浏览 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme浏览 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代谢路径 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
| 基因本体 | AmiGO / EGO | ||||||
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生物胺组织胺在许多生理过程中有重要的调节作用，包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸到组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛（PLP）的脱羧酶，并对其底物组氨酸有高度特异性。[4]
参考
- Epps HM. . Biochem. J. 1945, 39 (1): 42–6. PMC 1258146
. PMID 16747851. - Riley WD, Snell EE. . Biochemistry. October 1968, 7 (10): 3520–8. PMID 5681461.
- Rosenthaler J, Guirard BM, Chang GW, Snell EE. . Proc. Natl. Acad. Sci. U.S.A. July 1965, 54 (1): 152–8. PMC 285813 . PMID 5216347.
- . （原始内容存档于2020-03-28）.
- Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. . Hum. Genet. November 1992, 90 (3): 235–8. PMID 1487235.
扩展阅读
- Need AC, Keefe RS, Ge D; et al. . Eur. J. Hum. Genet. 2009, 17 (7): 946–57. PMID 19156168. doi:10.1038/ejhg.2008.264.
- Masini E, Fabbroni V, Giannini L; et al. . Inflamm. Res. 2005,. 54 Suppl 1: S80–1. PMID 15928846. doi:10.1007/s00011-004-0437-3.
- Li Z, Liu J, Tang F; et al. . APMIS. 2008, 116 (12): 1034–42. PMID 19133005. doi:10.1111/j.1600-0463.2008.01048.x.
- Szafranski K, Schindler S, Taudien S; et al. . Genome Biol. 2007, 8 (8): R154. PMID 17672918. doi:10.1186/gb-2007-8-8-r154.
- Ai W, Liu Y, Langlois M, Wang TC. . J. Biol. Chem. 2004, 279 (10): 8684–93. PMID 14670968. doi:10.1074/jbc.M308278200.
- Raychowdhury R, Fleming JV, McLaughlin JT; et al. . Biochem. Biophys. Res. Commun. 2002, 297 (5): 1089–95. PMID 12372397.
- Kimura K, Wakamatsu A, Suzuki Y; et al. . Genome Res. 2006, 16 (1): 55–65. PMID 16344560. doi:10.1101/gr.4039406.
- Sköldberg F, Portela-Gomes GM, Grimelius L; et al. . J. Clin. Endocrinol. Metab. 2003, 88 (4): 1445–52. PMID 12679420.
- Brew O, Lakasing L, Sullivan M. . Placenta: 585–7. PMID 16822545. doi:10.1016/j.placenta.2006.05.003.
- Zhang F, Xiong DH, Wang W; et al. . Biochem. Biophys. Res. Commun. 2006, 348 (4): 1378–82. PMID 16919600. doi:10.1016/j.bbrc.2006.08.008.
- Tippens AS, Gruetter CA. . Inflamm. Res. 2004, 53 (6): 215–6. PMID 15167966. doi:10.1007/s00011-004-1252-6.
- Siezen CL, Bont L, Hodemaekers HM; et al. . Pediatr. Infect. Dis. J. 2009, 28 (4): 333–5. PMID 19258923. doi:10.1097/INF.0b013e31818e2aa9.
- Morgan TK, Montgomery K, Mason V; et al. . Kidney Int. 2006, 70 (2): 306–14. PMID 16760908. doi:10.1038/sj.ki.5001553.
- Papadopoulou N, Kalogeromitros D, Staurianeas NG; et al. . J. Invest. Dermatol. 2005, 125 (5): 952–5. PMID 16297195. doi:10.1111/j.0022-202X.2005.23913.x.
- Janssen R, Bont L, Siezen CL; et al. . J. Infect. Dis. 2007, 196 (6): 826–34. PMID 17703412. doi:10.1086/520886.
- Strausberg RL, Feingold EA, Grouse LH; et al. . Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899.
- Aichberger KJ, Mayerhofer M, Vales A; et al. . Blood. 2006, 108 (10): 3538–47. PMID 16849647. doi:10.1182/blood-2005-12-028456.
- Lee JK, Kim HT, Cho SM; et al. . J. Hum. Genet. 2003, 48 (5): 213–6. PMID 12768436. doi:10.1007/s10038-003-0011-9.
- Jeong HJ, Moon PD, Kim SJ; et al. . Cell. Mol. Life Sci. 2009, 66 (7): 1309–19. PMID 19266161. doi:10.1007/s00018-009-9001-1.
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