罗非昔布

罗非昔布或罗非考昔（英語：，/ˌrɒfɪˈkɒksɪb/）商品名Vioxx、Ceoxx和Ceeoxx。是一种非甾体类抗炎药（NSAID），由默克公司製造、出售。美国食品药品监督管理局（FDA）于1999年5月20日批准上市，用以治疗骨关节炎、急性疼痛和痛经。

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罗非昔布
臨床資料
懷孕分級
  • 澳: C
给药途径oral
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度93%
血漿蛋白結合率87%
药物代谢hepatic
生物半衰期17 hours
排泄途徑biliary/renal
识别
  • 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one
CAS号162011-90-7  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.230.077
化学
化学式C17H14O4S
摩尔质量314.357 g/mol
3D模型（JSmol）
  • O=C2OCC(=C2\c1ccccc1)\c3ccc(cc3)S(=O)(=O)C
  • InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 checkY
  • Key:RZJQGNCSTQAWON-UHFFFAOYSA-N checkY

由於發現到長期且高劑量用藥有增加心臟病的風險[1][2]，默克公司於2004年9月30日起從市場撤回此藥。

合成
罗非昔布的合成[3]

注脚
  1. . [2017-02-26]. （原始内容存档于2017-09-12）.
  2. . [2017-02-26]. （原始内容存档于2017-04-23）.
  3. . Vioxxlawyer.org. [4 January 2015]. （原始内容存档于2015年1月5日）.

参考文献
  • FDA (2005). "Summary minutes for the February 16, 17 and 18, 2005, Joint meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee." Published on the internet, March 2005. Link （页面存档备份，存于）
  • Fitzgerald GA, Coxibs and Cardiovascular Disease, N Engl J Med 2004;351(17): 1709–1711. PMID 15470192.
  • Grassley CE (15 Oct 2004). Grassley questions Merck about communication with the FDA on Vioxx. Press Release.
  • Jüni P, Nartey L, Reichenbach S, Sterchi R, Dieppe PA, Egger M (2004). Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet (published online; see also Merck response below)
  • Karha J and Topol EJ. The sad story of Vioxx, and what we should learn from it （页面存档备份，存于） Cleve Clin J Med 2004; 71(12):933-939. PMID 15641522
  • Michaels, D. (June 2005) DOUBT Is Their Product Archive.is的存檔，存档日期2006-03-21, Scientific American, 292 (6).
  • Merck & Co., (5 Nov 2004). Response to Article by Juni et al. Published in The Lancet on Nov. 5. Press Release.
  • Merck & Co (30 Sep 2004) Merck Announces Voluntary Worldwide Withdrawal of VIOXX. Press release .
  • D. M. Mukherjee, S. E. Nissen, and E. J. Topol, "Risk of Cardiovascular Events Associated with Selective COX-2 Inhibitors," Journal of the American Medical Association 186 (2001): 954–959.
  • Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005;352(11):1081-91. PMID 15713945
  • Okie, S (2005) "Raising the safety bar--the FDA's coxib meeting." N Engl J Med. 2005 Mar 31;352(13):1283-5. PMID 15800221.
  • Leleti Rajender Reddy, Corey EJ. Facile air oxidation of the conjugate base of rofecoxib (Vioxx), a possible contributor to chronic human toxicity Tetrahedron Lett 2005, 46: 927. doi:10.1016/j.tetlet.2004.12.055
  • Swan SK et al., Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet. Annals of Int Med 2000; 133:1–9
  • Targum, SL. (1 Feb. 2001) Review of cardiovascular safety database. FDA memorandum. （页面存档备份，存于）
  • Wolfe, MM et al., Gastrointestinal Toxicity of Nonsteroidal Anti-anflamattory Drugs, New England Journal of Medicine. 1999; 340; 1888-98.

外部链接
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