美雌醇

美雌醇英語:,或称为炔雌醇甲醚,商品名有Enovid、Norinyl、Ortho-Novum等),分子式C21H26O2,是一种雌激素药物,代謝產物炔雌醇[4],作为复合口服避孕药[5]月经失调激素替代療法药物[6]

美雌醇
臨床資料
商品名Enovid, Norinyl, Ortho-Novum, others
其他名稱Ethinylestradiol 3-methyl ether; EEME; EE3ME; CB-8027; L-33355; RS-1044; 17α-Ethynylestradiol 3-methyl ether; 17α-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17β-ol; 3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17β-ol
AHFS/Drugs.com国际药品名称
MedlinePlusa601050
给药途径口服给药[1]
藥物類別雌激素; Estrogen ether
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 处方药(-only)
藥物動力學數據
代謝產物炔雌醇
生物半衰期Mestranol: 50 分钟[2]
EE: 7–36 小时[3][4][5][6]
识别
  • (8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
CAS号72-33-3  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.707
化学
化学式C21H26O2
摩尔质量310.44 g·mol−1
3D模型(JSmol
  • O(c1cc4c(cc1)[C@H]3CC[C@]2([C@@H](CC[C@]2(C#C)O)[C@@H]3CC4)C)C
  • InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1 checkY
  • Key:IMSSROKUHAOUJS-MJCUULBUSA-N checkY

参考文献

  1. I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 6 December 2012: 177–. ISBN 978-94-011-4439-1.
  2. Benno Runnebaum; Thomas Rabe. . Springer-Verlag. 17 April 2013: 88– [2022-11-27]. ISBN 978-3-662-07635-4. (原始内容存档于2022-10-14).
  3. Claude L Hughes; Michael D. Waters. . Humana Press. 23 March 2016: 73–. ISBN 978-3-319-27449-2.
  4. Goldzieher JW, Brody SA. . American Journal of Obstetrics and Gynecology. 1990, 163 (6 Pt 2): 2114–9. PMID 2256522. doi:10.1016/0002-9378(90)90550-Q.
  5. Stanczyk FZ, Archer DF, Bhavnani BR. . Contraception. 2013, 87 (6): 706–27. PMID 23375353. doi:10.1016/j.contraception.2012.12.011.
  6. Shellenberger, T. E. . 1986: 393–410. ISBN 978-94-010-8339-3. doi:10.1007/978-94-009-4145-8_36. |journal=被忽略 (帮助); 缺少或|title=为空 (帮助)

外部链接

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