脂氧合酶
脂氧合酶[2]（英語：，简称为LOX，EC 1.13.11.-）是一类含铁酶家族，催化脂类中含有顺,顺-1,4-戊二烯结构的多不饱和脂肪酸的双加氧化。主要催化以下过程：
- 脂肪酸 + O2 = 脂肪酸过氧化物
| 脂氧合酶 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 兔子网状细胞15S-脂氧合酶的结构[1]。 | |||||||||||
| 鑑定 | |||||||||||
| 標誌 | Lipoxygenase | ||||||||||
| Pfam | PF00305（旧版） | ||||||||||
| InterPro | IPR013819 | ||||||||||
| PROSITE | PDOC00077 | ||||||||||
| SCOP | 2sbl / SUPFAM | ||||||||||
| OPM家族 | 87 | ||||||||||
| OPM蛋白 | 1zq4 | ||||||||||
| |||||||||||
脂氧合酶存在于植物、动物与真菌之中。脂氧合酶的产物涉及到多种细胞功能。
参考文献
- Choi J, Chon JK, Kim S, Shin W. . Proteins. February 2008, 70 (3): 1023–32. PMID 17847087. doi:10.1002/prot.21590.
外部链接
- LOX-DB - LipOXygenases DataBase
- Lipoxygenases iron-binding region （页面存档备份，存于） in PROSITE
- PDB 1YGE - structure of lipoxygenase-1 from soybean (Glycine max)
- PDB 1IK3 - structure of soybean lipoxygenase-3 in complex with (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
- PDB 1LOX - structure of rabbit 15-lipoxygenase in complex with inhibitor
- Template:UMichOPM - animal lipoxygenases
- 醫學主題詞表（MeSH）：Lipoxygenase
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