蝴蝶霉素

**蝴蝶霉素**
臨床資料
其他名稱	7,10-dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
ATC碼	未分配;
识别
	IUPAC命名法 1,11-dichloro-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; ;
CAS号	93908-02-2
PubChem CID	73110;
ChemSpider	65891 ;
UNII	Y96MQM21V9;
ChEBI	CHEBI:135511 ;
ChEMBL	ChEMBL370100 ;
CompTox Dashboard (EPA)	DTXSID70239880 ;
化学
化学式	C27H21Cl2N3O7
摩尔质量	570.38 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CO[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)N2C3=C(C=CC=C3Cl)C4=C5C(=C6C7=C(C(=CC=C7)Cl)NC6=C42)C(=O)NC5=O)CO;
	InChI InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t13-,22-,23-,24-,27-/m1/s1 ; Key:QEHOIJJIZXRMAN-QZQSLCQPSA-N ;

蝴蝶霉素（英語：，开发代号：NSC 655649）是一种分离自诺卡氏菌属（Nocardia sp）细菌的吲哚咔唑类化合物，结构上与星形孢菌素类似，对第一型拓撲異構酶具有弱抑制活性[1]。

参考文献

Nettleton DE, Doyle TW, Krishnan B, Matsumoto GK, Clardy J. . Tetrahedron Letters. January 1985, 26 (34): 4011–4014. doi:10.1016/S0040-4039(00)89280-1.
Bush JA, Long BH, Catino JJ, Bradner WT, Tomita K. . The Journal of Antibiotics. May 1987, 40 (5): 668–78. PMID 3112080. doi:10.7164/antibiotics.40.668 .
Anizon F, Belin L, Moreau P, Sancelme M, Voldoire A, Prudhomme M, et al. . Journal of Medicinal Chemistry. October 1997, 40 (21): 3456–65. PMID 9341921. doi:10.1021/jm9702084.
Bailly C, Riou JF, Colson P, Houssier C, Rodrigues-Pereira E, Prudhomme M. . Biochemistry. April 1997, 36 (13): 3917–29. PMID 9092822. doi:10.1021/bi9624898.
Bailly C, Qu X, Graves DE, Prudhomme M, Chaires JB. . Chemistry & Biology. May 1999, 6 (5): 277–86. PMID 10322124. doi:10.1016/S1074-5521(99)80073-8 .

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