载脂蛋白B

载脂蛋白B
識別號
别名	APOB；, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B, FCHL2
外部ID	OMIM：107730 MGI：88052 HomoloGene：328 GeneCards：APOB
相關疾病
	代謝疾病、心血管疾病、血脂異常、familial hypobetalipoproteinemia 1、hypercholesterolemia, autosomal dominant, type b、家族性高胆固醇血症、hypobetalipoproteinemia[1]
基因位置（人类）
染色体	2號染色體[2]
终止	21,044,073 bp[2]
基因位置（小鼠）
染色体	小鼠12号染色体[3]
终止	8,066,835 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • lipid binding; • lipid transporter activity; • cholesterol transfer activity; • lipase binding; • low-density lipoprotein particle receptor binding; • phospholipid binding; • heparin binding; • signaling receptor binding;
細胞組分	• 早期内吞体; • chylomicron remnant; • vesicle lumen; • 内质网; • endosome membrane; • mature chylomicron; • endoplasmic reticulum lumen; • vesicle membrane; • endosome lumen; • intermediate-density lipoprotein particle; • clathrin-coated endocytic vesicle membrane; • endoplasmic reticulum membrane; • 外排體; • endocytic vesicle lumen; • neuronal cell body; • 細胞質; • 乳糜微粒; • very-low-density lipoprotein particle; • low-density lipoprotein particle; • endoplasmic reticulum exit site; • 細胞外空間; • smooth endoplasmic reticulum; • 细胞质基质; • 细胞膜; • lysosomal lumen; • 細胞內膜結合細胞器; • 細胞外區域; • high-density lipoprotein particle;
生物學過程	• artery morphogenesis; • in utero embryonic development; • 受精; • 受体介导的内吞作用; • positive regulation of cholesterol storage; • 脂質代謝; • cholesterol metabolic process; • cholesterol transport; • regulation of cholesterol biosynthetic process; • lipid transport; • 神經系統的發育; • leukocyte migration; • response to carbohydrate; • retinoid metabolic process; • steroid metabolic process; • triglyceride mobilization; • lipid catabolic process; • response to lipopolysaccharide; • positive regulation of macrophage derived foam cell differentiation; • cellular response to prostaglandin stimulus; • response to virus; • positive regulation of lipid storage; • cellular response to tumor necrosis factor; • response to selenium ion; • flagellated sperm motility; • positive regulation of gene expression; • response to organic substance; • cholesterol homeostasis; • 精子发生; • triglyceride catabolic process; • cholesterol efflux; • post-embryonic development; • lipoprotein transport; • toll-like receptor signaling pathway; • response to estradiol; • membrane organization; • chylomicron remodeling; • low-density lipoprotein particle remodeling; • chylomicron assembly; • very-low-density lipoprotein particle assembly; • chylomicron remnant clearance; • low-density lipoprotein particle clearance; • very-low-density lipoprotein particle clearance; • lipoprotein metabolic process; • lipoprotein biosynthetic process; • lipoprotein catabolic process; • 翻译后修饰; • transport;
	Sources:Amigo / QuickGO
直系同源
	338
	238055
	ENSG00000084674
	ENSMUSG00000020609
	P04114
	E9Q414
	NM_000384
	NM_009693
	NP_000375
	NP_033823
	維基數據

载脂蛋白B（英語：，缩写ApoB，也称为脂蛋白B100 英語：）是乳糜微粒、極低密度脂蛋白、中密度脂蛋白、低密度脂蛋白上的主要載脂蛋白[6][7]，其由人类APOB基因编码。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000084674 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020609 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR. . Journal of Clinical Lipidology. 2011, 5 (4): 264–272. PMID 21784371. doi:10.1016/j.jacl.2011.05.004.
Jacobson TA. . Mayo Clinic Proceedings. 2011, 86 (8): 762–780. PMC 3146376 . PMID 21803958. doi:10.4065/mcp.2011.0128.

外部链接

Database of RNA editing (DARNED) （页面存档备份，存于）.
Applied Research on Apolipoprotein-B （页面存档备份，存于）
Human APOB genome location and APOB gene details page in the UCSC Genome Browser.

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000084674 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000020609 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR. . Journal of Clinical Lipidology. 2011, 5 (4): 264–272. PMID 21784371. doi:10.1016/j.jacl.2011.05.004.

[7] Jacobson TA. . Mayo Clinic Proceedings. 2011, 86 (8): 762–780. PMC 3146376 . PMID 21803958. doi:10.4065/mcp.2011.0128.