马山茶碱

马山茶碱（英语：Tabernanthine）是一种在鹅花树中发现的生物碱。[1]它已被用于实验室实验，以研究成瘾如何影响大脑。[2]马山茶碱可持续减少大鼠可卡因和吗啡的自我给药。[3]

马山茶碱
Skeletal formula of tabernanthine
Ball-and-stick model of the tabernanthine molecule
臨床資料
ATC碼
  • 未分配
识别
  • (1R,15R,17S,18S)-17-ethyl-6-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene
CAS号83-94-3
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
化学
化学式C20H26N2O
摩尔质量310.44 g·mol−1
3D模型（JSmol）
  • CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=CC(=C5)OC
  • InChI=1S/C20H26N2O/c1-3-13-8-12-9-17-19-16(6-7-22(11-12)20(13)17)15-5-4-14(23-2)10-18(15)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13+,17+,20+/m1/s1
  • Key:UCIDWKVIQZIKEK-CFDPKNGZSA-N

药理学

它是κ-阿片激动剂（Ki=0.15μM）和NMDA受体（Ki=10.5μM）拮抗剂。[4][5]与伊波加因相比，它与σ1和σ2受体的结合较弱。[5]

参见
  • 冠狗牙花定碱
  • 依波加明
  • 伏康京碱
  • 山辣椒碱
  • Tabernanthalog

参考资料
  1. Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. . Journal of the American Chemical Society. 1958, 80: 126–136. doi:10.1021/ja01534a036.
  2. Levi MS, Borne RF. . Curr. Med. Chem. October 2002, 9 (20): 1807–18. PMID 12369879. doi:10.2174/0929867023368980.
  3. Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW J, Carlson JN. . Brain Res. September 1994, 657 (1–2): 14–22. PMID 7820611. S2CID 1940631. doi:10.1016/0006-8993(94)90948-2. 温哥华格式错误 (帮助)
  4. Deecher DC, Teitler M, Soderlund DM, Bornmann WG, Kuehne ME, Glick SD. . Brain Research. February 1992, 571 (2): 242–7. PMID 1377086. S2CID 17159661. doi:10.1016/0006-8993(92)90661-r.
  5. Christophe Wiart. . Academic Press. 16 December 2013: 67–69, 73. ISBN 978-0-12-398383-1.
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