1-羟基菲

1-羟基菲（英語：）或叫1-羟菲，是一种菲酚和菲的人体代谢物，可以在暴露于多环芳香烃的人的尿液中检测到。[1]

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1-羟基菲
Chemical structure of 1-hydroxyphenanthrene
IUPAC名
Phenanthren-1-ol
菲-1-酚
别名 1-菲酚
1-菲醇
1-羟基菲
1-羟菲
识别
CAS号 2433-56-9  checkY
PubChem 98490
ChemSpider 88945
SMILES
 
  • C1=CC=C2C(=C1)C=CC3=C2C=CC=C3O
性质
化学式 C14H10O
194.23 g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

它还可以用作海洋鱼胆汁中多环芳香烃污染的标记物。[2]

在菲生物降解的情况下，模型真菌雅致小克银汉霉产生1-羟基菲（菲1-O-β-葡萄糖）的糖苷共轭物。[3]

与吸烟的关系

对于2-、3-和4-羟基菲和1-羟基芘，发现了与每天吸食的香烟有关的高度显着差异和剂量反应关系，但对于1-羟基菲则没有。[4]

参考资料
  1. PAH metabolites (1-hydroxyphenanthrene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene). The MAK Collection for Occupational Health and Safety, Biomonitoring Methods, Vol. 6 (article （页面存档备份，存于）)
  2. PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes. Ulrike Kammann, Environmental Science and Pollution Research - International, March 2007, Volume 14, Issue 2, pages 102-108, doi:10.1065/espr2006.05.308
  3. Cerniglia, C. E.; Campbell, W. L.; Freeman, J. P.; Evans, F. E. . Applied and Environmental Microbiology. 1989, 55 (9): 2275–2279. PMC 203068 可免费查阅. PMID 2802607. doi:10.1128/AEM.55.9.2275-2279.1989.
  4. Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, doi:10.1007/s004200000215

外部链接
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