11β-甲氧基雌二醇

11β-甲氧基雌二醇（英語：，缩写11β-MeOE2，开发代号RU-2504）是一种人工合成的雌激素类甾体化合物，分子式C19H26O3，从未上市[1][2][3]，结构上与莫克雌醇（11β-甲氧基-17α-乙炔基雌二醇）类似[3][2]，其对雌激素受体的亲和力约为雌二醇的 86%[1][2]。

11β-甲氧基雌二醇
臨床資料
其他名稱11β-MeOE2; 11βOMeEST; RU-2504; 11β-Methoxyestra-1,3,5(10)-triene-3,17β-diol
藥物類別Estrogen
识别
  • (8S,9S,11S,13S,14S,17S)-11-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS号21507-14-2  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C19H26O3
摩尔质量302.41 g·mol−1
3D模型（JSmol）
  • C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O)OC
  • InChI=1S/C19H26O3/c1-19-10-16(22-2)18-13-6-4-12(20)9-11(13)3-5-14(18)15(19)7-8-17(19)21/h4,6,9,14-18,20-21H,3,5,7-8,10H2,1-2H3/t14-,15-,16-,17-,18+,19-/m0/s1
  • Key:OAHDOJSNKCCHJM-VIUKOLAESA-N

参考资料
  1. Wolohan P, Reichert DE. . Steroids. March 2007, 72 (3): 247–260. PMC 1964785 可免费查阅. PMID 17280694. doi:10.1016/j.steroids.2006.11.011.
  2. Katzenellenbogen JA, Muthyala R. . Pure and Applied Chemistry. 2003, 75 (11–12): 1797–1817. ISSN 1365-3075. S2CID 86680540. doi:10.1351/pac200375111797.
  3. Azadian-Boulanger G, Bertin D. [Synthesis and uterotropic activity of 11β-methoxyestradiol, 11β-methoxyestriol, and 11β-methoxy-17α-ethynylestradiol]. Chimica Therapeutica. 1973, 8 (4): 451–454. ISSN 0009-4374. The prepn. and estrogenic activity of the 11β-methoxylated derivs. of estradiol, estriol, and 17α-ethynylestradiol were described. When administered orally to mice, the 3 compds. were from 10 to 1000 times more active than the corresponding nonmethoxylated estrogens.
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