2-氯甲基吡啶

2-氯甲基吡啶
	IUPAC名; 2-(Chloromethyl)pyridine
识别
CAS号	4377-33-7
PubChem	23393
ChemSpider	21875
SMILES	C1=CC=NC(=C1)CCl;
ChEBI	76601
性质
化学式	C6H6ClN
摩尔质量	127.57 g·mol−1
外观	浅黄色或白色粉末
熔点	79 °C[1]
危险性
	GHS危险性符号;
GHS提示词	危险
H-术语	H302, H314
P-术语	P260, P264, P270, P280, P301+312+330, P301+330+331, P310, P363, P405, P501
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2-氯甲基吡啶是一种有机氯化合物，化学式为C₆H₆CClN，它是吡啶邻位（2号位）的氢被氯甲基取代的化合物。它可用于合成其它吡啶类配体。[2][3]

合成与反应

2-氯甲基吡啶可由吡啶-2-甲醇和氯化亚砜在二氯甲烷中反应制得。[4]它和甲胺在三乙胺存在下反应，可以得到N-甲基吡啶甲胺。[5]

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Buhaibeh, Ruqaya; Duhayon, Carine; Valyaev, Dmitry A.; Sortais, Jean-Baptiste; Canac, Yves. . Organometallics. 2021, 40 (2): 231–241. S2CID 234156476. doi:10.1021/acs.organomet.0c00717.
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Yan, Yu-Hang; Li, Wenfang; Chen, Wei; Li, Chao; Zhu, Kai-Rong; Deng, Ji; Dai, Qing-Qing; Yang, Ling-Ling; Wang, Zhenling; Li, Guo-Bo. . European Journal of Medicinal Chemistry. 2022, 228: 113965. doi:10.1016/j.ejmech.2021.113965.
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