2-溴-5-硝基吡啶

2-溴-5-硝基吡啶是一种有机溴化合物，化学式为C5H3BrN2O2。它可由5-硝基-2-吡啶酮和溴、三溴化磷在1,2-二氯乙烷中（或和四丁基溴化铵、五氧化二磷在苯中[1]）反应制得。[2]它和吡咯烷、碳酸钾反应，可以得到5-硝基-2-(1-吡咯烷基)吡啶。[3]

2-溴-5-硝基吡啶
识别
CAS号 4487-59-6  checkY
PubChem 78240
SMILES
 
  • O=N(=O)C1=CN=C(Br)C=C1
性质
化学式 C5H3BrN2O2
摩尔质量 202.99 g·mol−1
熔点 138-139 °C[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献
  1. Sagitullina, G. P., Vorontsova, M. A., Garkushenko, A. K., Poendaev, N. V., & Sagitullin, R. S. (2010). Nitropyridines: X. Palladium-catalyzed cross-coupling of 2-bromo-5-nitropyridine with terminal acetylenes. Russian Journal of Organic Chemistry, 46(12), 1830–1834. doi:10.1134/s1070428010120109
  2. Ager, David J.; Erickson, Robert A.; Froen, Diane E.; Prakash, Indra; Zhi, Ben. The synthesis of the high-potency sweetener, NC-00637. Part 2: preparation of the pyridine moiety. Organic Process Research & Development (2004), 8(1), 62-71. doi:10.1021/op034110c.
  3. Takahashi, Eiki; Hirano, Noriyuki; Nagahara, Takashi; Yoshikawa, Satoru; Momen, Shinobu; Yokokawa, Hiroshi; Hayashi, Ryoji. Bioorganic & Medicinal Chemistry Letters (2013), 23(11), 3154-3156. doi:10.1016/j.bmcl.2013.04.016.
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