5α-双氢诺龙

5α-双氢诺龙（英語：，缩写5α-DHN、DHN）也被称为5α-双氢-19-去甲睾酮（5α-dihydro-19-nortestosterone）或5α-雌烷-17β-醇-3-酮（5α-estran-17β-ol-3-one）是一种天然同化類固醇（AAS）和诺龙（19-去甲睾酮）的5α還原衍生物[2]，和5α還原酶催化睾酮生成5α-双氢睾酮（DHT）类似，5α還原酶也可催化19-去甲睾酮生成5α-双氢诺龙[2][3]。

5α-双氢诺龙
臨床資料
其他名稱Dihydronandrolone; DHN; 5α-DHN; 5α-Dihydro-19-nortestosterone; 5α-Estran-17β-ol-3-one; 19-nor-5α-androstan-17β-ol-3-one
识别
  • (5S,8R,9R,10S,13S,14S,17S)-17-Hydroxy-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one
CAS号1434-85-1  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C18H28O2
摩尔质量276.42 g·mol−1
3D模型（JSmol）
熔点130—131 °C（266—268 °F） [1]
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@@H]4[C@@H]3CCC(=O)C4
  • InChI=1S/C18H28O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h11,13-17,20H,2-10H2,1H3/t11-,13-,14+,15+,16-,17-,18-/m0/s1
  • Key:RHVBIEJVJWNXBU-PNOKGRBDSA-N

参考文献
  1. A. Bowers, H. J. Ringold, E. Denot. . Journal of the American Chemical Society. 1958-11, 80 (22): 6115–6118 [2021-01-21]. ISSN 0002-7863. doi:10.1021/ja01555a054 （英语）.
  2. Kicman AT. . British Journal of Pharmacology. June 2008, 154 (3): 502–21. PMC 2439524 可免费查阅. PMID 18500378. doi:10.1038/bjp.2008.165.
  3. John A. Thomas. . Springer Science & Business Media. 6 December 2012: 29–. ISBN 978-1-4684-5499-4.
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