5-HT₄受體

5-HT4受體
識別號
别名	HTR4；, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
外部ID	OMIM：602164 MGI：109246 HomoloGene：20243 GeneCards：HTR4
為以下藥物的標靶
	维拉佐酮、血清素、5-甲氧基色胺、α-methyl-5-HT、莫沙必利、伦扎必利、扎考必利、普芦卡必利、RS 67333、GR-113808、哌波色罗、SB 204070、levosulpiride、齐美定、capeserod、relenopride、td-8954、metoclopramide hydrochloride hydrate[1]
基因位置（人类）
染色体	5號染色體[2]
终止	148,677,235 bp[2]
基因位置（小鼠）
染色体	小鼠18号染色体[3]
终止	62,629,648 bp[3]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • trace-amine receptor activity; • 相同蛋白质结合; • neurotransmitter receptor activity; • 血浆蛋白结合;
細胞組分	• 細胞質; • integral component of membrane; • 核内体; • 细胞膜; • integral component of plasma membrane; • 膜; • 树突;
生物學過程	• gamma-aminobutyric acid signaling pathway; • G protein-coupled receptor signaling pathway; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • regulation of appetite; • 訊息傳遞; • 化学性突触传递; • G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	3360
	15562
	ENSG00000164270
	ENSMUSG00000026322
	Q13639
	P97288
NM_000870; NM_001040169; NM_001040172; NM_001040173; NM_001040174;
	NM_001286410; NM_199453
	NM_008313; NM_001364956; NM_001364957; NM_001364958; NM_001364959
NP_000861; NP_001035259; NP_001035262; NP_001035263; NP_001273339;
	NP_955525
	NP_032339; NP_001351885; NP_001351886; NP_001351887; NP_001351888
	維基數據

5-HT₄受體或5-羥色胺受體4（英語：）是在人類上由HTR4基因編碼的蛋白質[6][7]。

配體

激動劑

BIMU-8
Cisapride
ML-10302[8]
莫沙必利
Prucalopride
Renzapride
RS-67506
Tegaserod
Zacopride
Metoclopramide
舒必利
RS-67333 - partial agonist
SL65.0155 - partial agonist
CJ-033,466 - partial agonist

拮抗劑

Piboserod
GR-113,808 (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)[9]
GR-125,487
RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
SB-203,186
SB-204,070
([Methoxy-¹¹C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate[10]
洋甘菊(酒精萃取)[11]

參見

5-羟色胺受体
5-HT₁受體
5-HT2受體
5-HT₃受體
5-HT₅受體
5-HT₆受體
5-HT₇受體

參考資料

.
GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. . Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646.
Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. . FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X.
Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. . Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020.
Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. . British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004 . PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x.
Xu R, Hong J, Morse CL, Pike VW. . Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497 . PMID 20812727. doi:10.1021/jm100668r.
Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. . Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012.

深入閱讀

Licht CL, 2009, Changes in the 5-HT₄ receptor in animal models of depression and antidepressant treatment, PhD thesis, University of Copenhagen.
Ullmer C, Schmuck K, Kalkman HO, Lübbert H. . FEBS Letters. August 1995, 370 (3): 215–21. PMID 7656980. doi:10.1016/0014-5793(95)00828-W.
Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. . FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X.
Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E. . Journal of Neurochemistry. November 1997, 69 (5): 1810–9. PMID 9349523. doi:10.1046/j.1471-4159.1997.69051810.x.
Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A. . NeuroReport. October 1997, 8 (15): 3189–96. PMID 9351641. doi:10.1097/00001756-199710200-00002.
Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. . Journal of Neurochemistry. June 1998, 70 (6): 2252–61. PMID 9603189. doi:10.1046/j.1471-4159.1998.70062252.x.
Cichon S, Kesper K, Propping P, Nöthen MM. . Molecular Membrane Biology. 1998, 15 (2): 75–8. PMID 9724925. doi:10.3109/09687689809027521.
Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A. . Molecular Pharmacology. May 1999, 55 (5): 910–20. PMID 10220570.
Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W. . Journal of Neurochemistry. February 2000, 74 (2): 478–89. PMID 10646498. doi:10.1046/j.1471-4159.2000.740478.x.
Mialet J, Berque-Bestel I, Eftekhari P, Gastineau M, Giner M, Dahmoune Y, Donzeau-Gouge P, Hoebeke J, Langlois M, Sicsic S, Fischmeister R, Lezoualc'h F. . British Journal of Pharmacology. February 2000, 129 (4): 771–81. PMC 1571890 . PMID 10683202. doi:10.1038/sj.bjp.0703101.
Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO. . Naunyn-Schmiedeberg's Archives of Pharmacology. February 2001, 363 (2): 146–60. PMID 11218067. doi:10.1007/s002100000299.
Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger GJ. . Brain Research. Molecular Brain Research. June 2001, 90 (2): 125–34. PMID 11406291. doi:10.1016/S0169-328X(01)00095-X.
Hiroi T, Hayashi-Kobayashi N, Nagumo S, Ino M, Okawa Y, Aoba A, Matsui H. . Biochemical and Biophysical Research Communications. November 2001, 289 (2): 337–44. PMID 11716477. doi:10.1006/bbrc.2001.5979.
Vilaró MT, Doménech T, Palacios JM, Mengod G. . Neuropharmacology. January 2002, 42 (1): 60–73. PMID 11750916. doi:10.1016/S0028-3908(01)00154-X.
López-Rodríguez ML, Murcia M, Benhamú B, Olivella M, Campillo M, Pardo L. . Journal of Computer-Aided Molecular Design. November 2001, 15 (11): 1025–33. PMID 11989623. doi:10.1023/A:1014895611874.
Ohtsuki T, Ishiguro H, Detera-Wadleigh SD, Toyota T, Shimizu H, Yamada K, Yoshitsugu K, Hattori E, Yoshikawa T, Arinami T. . Molecular Psychiatry. 2003, 7 (9): 954–61. PMID 12399948. doi:10.1038/sj.mp.4001133.
Norum JH, Hart K, Levy FO. . The Journal of Biological Chemistry. January 2003, 278 (5): 3098–104. PMID 12446729. doi:10.1074/jbc.M206237200.
Cartier D, Lihrmann I, Parmentier F, Bastard C, Bertherat J, Caron P, Kuhn JM, Lacroix A, Tabarin A, Young J, Vaudry H, Lefebvre H. . The Journal of Clinical Endocrinology and Metabolism. January 2003, 88 (1): 248–54. PMID 12519861. doi:10.1210/jc.2002-021107.
Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW. . Science. July 2003, 301 (5630): 226–9. PMID 12855812. doi:10.1126/science.1084674.

外部連結

. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2016-06-05）.

5-HT4受體引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9371406-6] Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. . Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646.

[pmid9276448-7] Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. . FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X.

[pmid21239110-8] Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. . Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020.

[9] Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. . British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004 . PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x.

[10] Xu R, Hong J, Morse CL, Pike VW. . Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497 . PMID 20812727. doi:10.1021/jm100668r.

[11] Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. . Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012.