5-羟色胺受体

5-羥色胺受體,也被稱為血清素受體5-HT受體,是一羣於中樞神經系統中央處末梢神經系統周邊出現的G蛋白偶聯受體及配體門控離子通道。[1][2]它們同時調節興奮性和抑制性神經傳導物質的傳遞。

5-HT1B 受體 作為代謝型血清素受體的一個例子。其呈現出緞帶狀的晶體結構。

分類

血清素受體可分為七個亞科 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7。至少有十四種受體亞型已被發現,包含G蛋白偶聯受體(G protein-coupled receptor)和配體門控離子通道(ligand-gated ion channel)。

  • 5-HT1受體是5-HT受體家族中最龐大的一科,包括5-HT1A、5-HT1B、5-HT1D、5-HT1E、5-HT1F五種受體蛋白。沒有5-HT1C受體,因為它被重新分類為5-HT2C受體。
  • 5-HT2受體亚家族包括5-HT2A5-HT2B,和5-HT2C三種受體蛋白。
  • 5-HT3受體
  • 5-HT4受體
  • 5-HT5受體亚家族包括5-HT5A、5-HT5B两種受體蛋白。(其中5B受体在人类中为假基因,无受体表达)
  • 5-HT6受體
  • 5-HT7受體

總共有十四種受體亞型。

除了5-HT3受体配体门控离子通道以外,其它的所有血清素受体都是G蛋白偶联受体,激活细胞内第二信使来产生效应。在2014年,在菜粉蝶基因组中发现了一种新的5-HT受体,被命名为pr5-HT8。它与已知的各类5-HT受体相似度很低,在哺乳动物中没有类似基因。[3]

家族

七個亞科 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7

家族類型作用機制類別
5-HT1Gi/Go-蛋白偶聯受体減少cAMP在細胞內的水平抑制性
5-HT2Gq/G11-蛋白偶聯受体增加細胞內IP3DAG的水平興奮性
5-HT3配體門控Na+K+离子通道使質膜去極化興奮性
5-HT4Gs蛋白偶聯受体增加細胞內cAMP的水平興奮性
5-HT5Gi/Go-蛋白偶聯受体[4]減少cAMP在細胞內的水平抑制性
5-HT6Gs-蛋白偶聯受体增加細胞內cAMP的水平興奮性
5-HT7Gs-蛋白偶聯受体增加細胞內cAMP的水平興奮性

亞型

血清素受體功能概述
受體 首次克隆 基因 分佈 作用 激動劑 拮抗劑 用途
血管 中樞神經系統 胃腸道 血小板 外周神經系統 平滑肌
5-HT1A 1987

選擇性

  • Vilazodone (Viibryd)
  • F-15,599 (research compound, highly potent and selective for 5-HT1A)
  • Flesinoxan (potent, EC50 = 24 nM)
  • Gepirone (部分激动剂, Ki = 70 nM)
  • 氟哌啶醇
  • Ipsapirone (部分激动剂, Ki = 12.1 nM)
  • 喹硫平
  • Trazodone (SARI, selective in the sense that on all other 5-HT receptors it acts as either an antagonist or has no action. Kd = 78nM)
  • 育亨宾 (unselective 部分激动剂)
  • 坦度螺酮 (potent and selective 部分激动剂)

非選擇性

  • BMY 7378
  • Cyanopindolol
  • Iodocyanopindolol
  • Lecozotan
  • Methiothepin
  • Methysergide[30]
  • NAN-190
  • Nebivolol
  • Nefazodone
  • WAY-100,135
  • WAY-100,635
  • Mefway
  • 镇痛药 (agonists)
  • 抗抑郁药 (post-synaptic receptor agonists and pre-synaptic autoreceptor antagonists serve as antidepressants)
  • Anxiolytics[31] (antagonist)
5-HT1B 1992
  • Alprenolol
  • AR-A000002
  • Asenapine
  • Cyanopindolol
  • GR-127,935
  • Iodocyanopindolol
  • Isamoltane
  • Metergoline
  • Methiothepin
  • Oxprenolol
  • Pindolol
  • 普萘洛尔
  • SB-216,641
  • 育亨宾
5-HT1D 1991
5-HT1E 1992
  • BRL-54443
  • None known
5-HT1F 1993
  • Migraine
  • BRL-54443
  • Lasmiditan
  • LY-334,370
  • Naratriptan
  • None known
5-HT2A 1988
  • 成瘾 (potentially modulating) [40]
  • 焦虑[41]
  • 食欲
  • Cognition
  • Imagination
  • Learning
  • 记忆
  • 情绪
  • Perception
  • 性行为[42]
  • 睡眠[43]
  • 体温调节[44]
  • 血管收缩[45]
5-HT2B 1992
5-HT2C 1988
5-HT3 1993
  • 成瘾
  • 焦虑
  • Emesis
  • GI Motility[62]
  • Learning[63]
  • 记忆[63]
  • Nausea
5-HT4 1995
5-HT5A 1994
  • Asenapine
  • Dimebolin
  • Methiothepin
  • Ritanserin
  • SB-699,551
  • SB-699,551-A
  • None thus far
5-HT5B 1993

Functions in rodents,
pseudogene in humans

  • None thus far
5-HT6 1993
  • EMD-386,088
  • EMDT
5-HT7 1993

注意没有5-HT1C受体。这是因为在克隆这个受体并进一步分类之后,发现它和5-HT2家族共同点更多,于是就改名成了5-HT2C受体。

对各5-HT受体亚型选择性极弱的激动剂有麦角胺(一种antimigraine,激活5-HT1A、5-HT1D、5-HT1B、D2、去甲肾上腺素受体[28])、LSD(一种合成迷幻药物,可以激活5-HT1A、5-HT2A、5-HT2C、5-HT5A、5-HT6)。[28]

参考资料

  1. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. . Pharmacol. Rev. 1994, 46 (2): 157–203 [2016-04-25]. PMID 7938165. (原始内容存档于2009-04-10).
  2. Frazer A, Hensler JG. . Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD, editors (编). . Philadelphia: Lippincott-Raven. 1999: 263–292 [2008-04-11]. ISBN 0-397-51820-X. (原始内容存档于2008-12-01).
  3. Qi YX, Xia RY, Wu YS, Stanley D, Huang J, Ye GY. . J. Neurochem. 2014, 131: 767–77. PMID 25187179. doi:10.1111/jnc.12940.
  4. Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE. . Eur J Pharmacol. 1998, 361 (2–3): 299–309. PMID 9865521. doi:10.1016/S0014-2999(98)00744-4.
  5. Tomkins DM, Higgins GA, Sellers EM. . Psychopharmacology (Berl). 1994, 115 (1–2): 173–9. PMID 7862892. doi:10.1007/BF02244769.
  6. Müller CP, Carey RJ, Huston JP, De Souza Silva MA. . Prog Neurobiol. 2007, 81 (3): 133–78. PMID 17316955. doi:10.1016/j.pneurobio.2007.01.001.
  7. Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP. . Brain Res. 2005, 1034 (1–2): 162–71. PMID 15713268. doi:10.1016/j.brainres.2004.12.012.
  8. de Boer SF, Koolhaas JM. . Eur J Pharmacol. 2005, 526 (1–3): 125–39. PMID 16310183. doi:10.1016/j.ejphar.2005.09.065.
  9. Parks CL, Robinson PS, Sibille E, Shenk T, Toth M. . Proceedings of the National Academy of Sciences of the United States of America. 1998, 195 (18): 10734–9. PMC 27964可免费查阅. PMID 9724773. doi:10.1073/pnas.95.18.10734.
  10. Ebenezer IS, Arkle MJ, Tite RM. . Methods Find Exp Clin Pharmacol. 1998, 29 (4): 269–72. PMID 17609739. doi:10.1358/mf.2007.29.4.1075362.
  11. Wouters W, Tulp MT, Bevan P. . Eur J Pharmacol. 1998, 149 (3): 213–23. PMID 2842163. doi:10.1016/0014-2999(88)90651-6.
  12. Horiuchi J, McDowall LM, Dampney RA. . Auton Neurosci. 2008, 142 (1–2): 71–6. PMID 18667366. doi:10.1016/j.autneu.2008.06.004.
  13. Nalivaiko E, Ootsuka Y, Blessing WW. . Am J Physiol Regul Integr Comp Physiol. 2005, 289 (2): R596–R604. PMID 15802554. doi:10.1152/ajpregu.00845.2004.
  14. Lucot JB. . Eur J Pharmacol. 1994, 253 (1–2): 53–60. PMID 8013549. doi:10.1016/0014-2999(94)90756-0.
  15. Winstanley CA, Theobald DE, Dalley JW, Robbins TW. . Neuropsychopharmacology. 2005, 30 (4): 669–682. PMID 15688093. doi:10.1038/sj.npp.1300610.
  16. Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O. . Behav. Brain Res. 2008, 195 (1): 54–77. PMID 18394726. doi:10.1016/j.bbr.2008.02.023.
  17. Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K. . Am J Psychiatry. 2003, 160 (2): 334–40. PMID 12562581. doi:10.1176/appi.ajp.160.2.334.
  18. Kennett GA, Dourish CT, Curzon G. . Eur J Pharmacol. 1987, 134 (3): 265–74. PMID 2883013. doi:10.1016/0014-2999(87)90357-8.
  19. Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC. . Pharmacology. 2003, 67 (4): 182–194. PMID 12595749. doi:10.1159/000068404.
  20. Millan MJ, Perrin-Monneyron S. . Eur J Pharmacol. 1997, 321 (3): 11–3. PMID 9085055. doi:10.1016/S0014-2999(97)00050-2.
  21. Prow MR, Martin KF, Heal DJ. . Eur J Pharmacol. 1996, 317 (1): 21–8. PMID 8982715. doi:10.1016/S0014-2999(96)00693-0.
  22. Meyer LC, Fuller A, Mitchell D. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. February 2006, 290 (2): R405–13. PMID 16166206. doi:10.1152/ajpregu.00440.2005.
  23. Popova NK, Amstislavskaya TG. . Psychoneuroendocrinology. 2002, 27 (5): 609–18. PMID 11965359. doi:10.1016/S0306-4530(01)00097-X.
  24. Monti JM, Jantos H. . J Sleep Res. 1992, 1 (3): 169–175. PMID 10607047. doi:10.1111/j.1365-2869.1992.tb00033.x.
  25. Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS. . Neuroscience. 2007, 146 (2): 509–14. PMID 17383105. doi:10.1016/j.neuroscience.2007.02.032.
  26. Gudelsky GA, Koenig JI, Meltzer HY. . Neuropharmacology. 1986, 25 (12): 1307–13. PMID 2951611. doi:10.1016/0028-3908(86)90101-2.
  27. Ootsuka Y, Blessing WW. . Brain Res. 2006,. 1073-1074: 252–61. PMID 16455061. doi:10.1016/j.brainres.2005.12.031.
  28. Pharmacology Corner > Serotonin (5-HT): receptors, agonists and antagonists 页面存档备份,存于 By Flavio Guzmán, M.D. on 9/08/09
  29. "BRINTELLIX™ (vortioxetine) tablets for oral use. Full Prescribing Information, Section 12.2 (Pharmacodynamics)." Takeda Pharmaceuticals America Inc. and Lundbeck, 2013. Revised September 2013. 页面存档备份,存于
  30. Saxena, PR; Lawang, A. . Archives Internationales de Pharmacodynamie et de Thérapie. Oct 1985, 277 (2): 235–52. PMID 2933009.
  31. Cao BJ, Rodgers RJ. . Psychopharmacology. October 1998, 139 (3): 185–94. PMID 9784072. doi:10.1007/s002130050703.
  32. Harrison AA, Parsons LH, Koob GF, Markou A. . Psychopharmacology (Berl). 1999, 141 (3): 242–50. PMID 10027505. doi:10.1007/s002130050831.
  33. Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E. . J Pharm Pharmacol. 2005, 57 (2): 253–7. PMID 15720791. doi:10.1211/0022357055399.
  34. Lin D, Parsons LH. . Pharmacol Biochem Behav. 2002, 71 (4): 581–7. PMID 11888549. doi:10.1016/S0091-3057(01)00712-2.
  35. Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E. . Behav Pharmacol. 2004, 15 (8): 523–34. PMID 15577451. doi:10.1097/00008877-200412000-00001.
  36. Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO. . Neuropharmacology. 2008, 54 (7): 1041–50. PMID 18394658. doi:10.1016/j.neuropharm.2008.02.007.
  37. McCreary AC, Bankson MG, Cunningham KA. . J Pharmacol Exp Ther. 1999, 290 (3): 965–73. PMID 10454466.
  38. Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J. . Eur Neuropsychopharmacol. 2005, 15 (3): 279–82. PMID 15820416. doi:10.1016/j.euroneuro.2004.12.002.
  39. Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB. . Neurosci Lett. 1996, 209 (3): 210–4. PMID 8736648. doi:10.1016/0304-3940(96)12637-9.
  40. 页面存档备份,存于 Bubar MJ, Cunningham KA. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem. 2006;6(18):1971-85.
  41. Schreiber R, Melon C, De Vry J. . Psychopharmacology (Berl). 1998, 135 (4): 383–91. PMID 9539263. doi:10.1007/s002130050526.
  42. Popova NK, Amstislavskaya TG. . Neuroendocrinology. 2002, 76 (1): 28–34. PMID 12097814. doi:10.1159/000063681.
  43. Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J. . J Neurosci. 2005, 25 (49): 11231–8. PMID 16339018. doi:10.1523/JNEUROSCI.1724-05.2005.
  44. Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL. . Psychopharmacology (Berl). 1997, 130 (2): 144–51. PMID 9106912. doi:10.1007/s002130050222.
  45. Blessing WW, Seaman B. . Neuroscience. 2003, 117 (4): 939–948. PMID 12654345. doi:10.1016/S0306-4522(02)00810-2.
  46. McCall, R. B.; Franklin, S. R.; Hyslop, D. K.; Knauer, C. S.; Chio, C. L.; Haber, C. L.; Fitzgerald, L. W. (Online) 27 (309.2). Presentation Number 309.2. Convention Center Exhibit Hall, Poster Board TT-45, San Diego, CA: Society for Neuroscience Abstracts. 2001 [18 July 2014]. (原始内容存档于2014-11-04). |conference=被忽略 (帮助)
  47. Garfield AS, Heisler LK. . The Journal of Physiology. 2009, 587 (1): 49–60. PMC 2670022可免费查阅. PMID 19029184. doi:10.1113/jphysiol.2008.164152.
  48. Jensen, Anders A.; Plath, Niels; Pedersen, Martin Holst Friborg; Isberg, Vignir; et al. . Journal of Medicinal Chemistry. 2013, 56 (3): 1211–1227. ISSN 0022-2623. doi:10.1021/jm301656h.
  49. Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP. . Br J Pharmacol. 1996, 117 (7): 1443–8. PMC 1909458可免费查阅. PMID 8730737. doi:10.1111/j.1476-5381.1996.tb15304.x.
  50. Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC. . Neuropharmacology. 1997, 36 (4–5): 601–8. PMID 9225285. doi:10.1016/S0028-3908(97)00042-7.
  51. Kennett GA, Trail B, Bright F. . Neuropharmacology. 1998, 37 (12): 1603–10. PMID 9886683. doi:10.1016/S0028-3908(98)00115-4.
  52. Kennett GA, Ainsworth K, Trail B, Blackburn TP. . Neuropharmacology. 1997, 36 (2): 233–9. PMID 9144661. doi:10.1016/S0028-3908(96)00171-2.
  53. Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. . Br J Pharmacol. 2002, 135 (5): 1144–1151. PMC 1573235可免费查阅. PMID 11877320. doi:10.1038/sj.bjp.0704571.
  54. Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP. . Neuropharmacology. 1997, 36 (4–5): 609–20. PMID 9225286. doi:10.1016/S0028-3908(97)00038-5.
  55. Millan MJ, Brocco M, Gobert A, Dekeyne A. . Psychopharmacology (Berl). 2005, 177 (4): 448–58. PMID 15289999. doi:10.1007/s00213-004-1962-z.
  56. Millan MJ, Brocco M, Gobert A, Dekeyne A. . Psychopharmacology (Berl). 2008, 199 (4): 549–68. PMID 18523738. doi:10.1007/s00213-008-1177-9.
  57. Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A. . Biol Psychiatry. 2009, 65 (9): 748–759. PMID 19058784. doi:10.1016/j.biopsych.2008.10.031.
  58. Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S. . Eur J Pharmacol. 1997, 325 (1): 9–12. PMID 9151932. doi:10.1016/S0014-2999(97)89962-1.
  59. Stancampiano R, Melis MR, Argiolas A. . Eur J Pharmacol. 1994, 261 (1–2): 149–55. PMID 8001637. doi:10.1016/0014-2999(94)90313-1.
  60. Frank MG, Stryker MP, Tecott LH. . Neuropsychopharmacology. 2002, 27 (5): 869–73. PMC 2452994可免费查阅. PMID 12431861. doi:10.1016/S0893-133X(02)00353-6.
  61. Rang, H. P. . Edinburgh: Churchill Livingstone. 2003. ISBN 0-443-07145-4. Page 187
  62. Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M. . National Center for Biotechnology Information. May 2005 [10 October 2014]. (原始内容存档于2016-09-23).
  63. Pitsikas N, Brambilla A, Borsini F. . Pharmacol Biochem Behav. 1994, 47 (1): 95–99. PMID 8115433. doi:10.1016/0091-3057(94)90116-3.
  64. Smriga M, Torii K. . Proceedings of the National Academy of Sciences of the United States of America. 2003, 100 (26): 15370–5. PMC 307574可免费查阅. PMID 14676321. doi:10.1073/pnas.2436556100.
  65. Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ. . Neuropharmacology. 1997, 36 (4–5): 707–12. PMID 9225297. doi:10.1016/S0028-3908(97)00037-3.
  66. Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V. . Proceedings of the National Academy of Sciences of the United States of America. 2007, 104 (41): 16335–40. PMC 2042207可免费查阅. PMID 17913892. doi:10.1073/pnas.0701471104.
  67. J Soc Biol.; Charnay, Y; Dusticier, N; Daszuta, A; Hen, R; Bockaert, J. . J Soc Biol. 2004, 198 (1): 37–49. PMID 15146954.
  68. Meneses A, Hong E. . Pharmacol Biochem Behav. 1997, 56 (3): 347–51. PMID 9077568. doi:10.1016/S0091-3057(96)00224-9.
  69. Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM. . Neuropharmacology. 1997, 36 (4–5): 689–96. PMID 9225295. doi:10.1016/S0028-3908(97)00055-5.
  70. Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM. . J Pharmacol Exp Ther. 1998, 286 (3): 1115–21. PMID 9732367.
  71. Lucas, G.; Rymar, V. V.; Du, J.; Mnie-Filali, O.; Bisgaard, C.; Manta, S.; Lambas-Senas, L.; Wiborg, O.; Haddjeri, N.; Piñeyro, G.; Sadikot, A. F.; Debonnel, G. . Neuron. 2007, 55 (5): 712–725. PMID 17785179. doi:10.1016/j.neuron.2007.07.041.
  72. Duman, R. S. . Neuron. 2007, 55 (5): 679–681. PMID 17785173. doi:10.1016/j.neuron.2007.08.011.
  73. Manzke, T. . Science. 2003, 301 (5630): 226–229. ISSN 0036-8075. PMID 12855812. doi:10.1126/science.1084674.
  74. Nelson DL. . Curr Drug Targets CNS Neurol Disord. 2004, 3 (1): 53–8. PMID 14965244. doi:10.2174/1568007043482606.
  75. Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. . Brain Res Mol Brain Res. 2005, 138 (2): 191–7. PMID 15921820. doi:10.1016/j.molbrainres.2005.04.009.
  76. Zhang, Shicheng; Chen, He; Zhang, Chengwei; Yang, Ying; Popov, Petr; Liu, Jing; Krumm, Brian E.; Cao, Can; Kim, Kuglae; Xiong, Yan; Katritch, Vsevolod. . Nature Structural & Molecular Biology. 2022-07, 29 (7) [2022-10-02]. ISSN 1545-9993. PMC 9299520可免费查阅. PMID 35835867. doi:10.1038/s41594-022-00796-6. (原始内容存档于2022-10-06) (英语).
  77. Wesolowska A. . European Journal of Pharmacology. February 2008, 580 (3): 355–60. PMID 18096153. doi:10.1016/j.ejphar.2007.11.022.
  78. Wesolowska A, Nikiforuk A. . Neuropharmacology. April 2007, 52 (5): 1274–83. PMID 17320917. doi:10.1016/j.neuropharm.2007.01.007.
  79. Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N. . European Journal of Pharmacology. December 2006, 553 (1–3): 109–19. PMID 17069795. doi:10.1016/j.ejphar.2006.09.049.
  80. Perez-García G, Meneses A. . Pharmacology, Biochemistry, and Behavior. July 2005, 81 (3): 673–82. PMID 15964617. doi:10.1016/j.pbb.2005.05.005.
  81. Wesolowska A, Nikiforuk A. . European Journal of Pharmacology. March 2008, 582 (1–3): 88–93. PMID 18234190. doi:10.1016/j.ejphar.2007.12.013.
  82. . The Association of the British Pharmaceutical Industry. [2008-04-11]. (原始内容存档于2008-06-12).
  83. Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG. . Biological Psychiatry. November 2005, 58 (10): 831–7. PMID 16018977. doi:10.1016/j.biopsych.2005.05.012.
  84. Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E. . Neuropharmacology. September 2006, 51 (3): 578–86. PMID 16828124. doi:10.1016/j.neuropharm.2006.04.017.
  85. Gasbarri A, Cifariello A, Pompili A, Meneses A. . Behavioural Brain Research. December 2008, 195 (1): 164–70. PMID 18308404. doi:10.1016/j.bbr.2007.12.020.
  86. Liy-Salmeron G, Meneses A. . Hippocampus. 2008, 18 (9): 965–74. PMID 18570192. doi:10.1002/hipo.20459.
  87. Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C. . J Pharmacol Exp Ther. 2007, 321 (2): 690–8. PMID 17314195. doi:10.1124/jpet.107.119404.
  88. Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT. . Br J Pharmacol. 2003, 139 (4): 705–14. PMC 1573887可免费查阅. PMID 12812993. doi:10.1038/sj.bjp.0705290.
  89. Davies MA, Sheffler DJ, Roth BL. Aripiprazole: A Novel Atypical Antipsychotic Drug With a Uniquely Robust Pharmacology. CNS Drug Reviews [Internet]. 2004 [cited 2013 Aug 4];10(4):317–36. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2004.tb00030.x/pdf 页面存档备份,存于

外部链接

  • 醫學主題詞表(MeSH)Serotonin+Receptors
  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. (原始内容存档于2016-06-01).
  • Rubenstein, LA, Lanzara RG. . Cogprints. 2005-02-16 [2008-04-11]. (原始内容存档于2011-05-16).

Template:Serotonergics

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