9-氨甲基-9,10-二氢蒽

9-氨甲基-9,10-二氢蒽（英语：），简称AMDA，是一种有机化合物，可作为5-HT2A受体的有效选择性拮抗剂。[1]它已被用于帮助研究5-HT2A蛋白的形状，[2]并开发出一大类具有更高效力和选择性的相关衍生物。[3][4][5][6][7]

9-氨甲基-9,10-二氢蒽
识别
  • 1-(9,10-Dihydroanthracen-9-yl)methanamine
CAS号22136-76-1  ☒N
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C15H15N
摩尔质量209.29 g·mol−1
3D模型（JSmol）
  • c3cccc1c3Cc2ccccc2C1CN
  • InChI=1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2 checkY
  • Key:GEICAQNIOJFRQN-UHFFFAOYSA-N checkY

参考资料
  1. Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. . European Journal of Pharmacology. September 1999, 380 (1): R5–7. PMID 10513561. doi:10.1016/S0014-2999(99)00525-7.
  2. Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. . Journal of Medicinal Chemistry. April 2002, 45 (8): 1656–64. PMID 11931619. doi:10.1021/jm010354g.
  3. Peddi S, Roth BL, Glennon RA, Westkaemper RB. . European Journal of Pharmacology. December 2003, 482 (1–3): 335–7. PMID 14660041. doi:10.1016/j.ejphar.2003.09.059.
  4. Peddi S, Roth BL, Glennon RA, Westkaemper RB. . Bioorganic & Medicinal Chemistry Letters. May 2004, 14 (9): 2279–83. PMID 15081025. doi:10.1016/j.bmcl.2004.02.014.
  5. Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. . Bioorganic & Medicinal Chemistry Letters. October 2008, 18 (19): 5268–71. PMC 3082371 可免费查阅. PMID 18774714. doi:10.1016/j.bmcl.2008.08.059.
  6. Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. . Journal of Medicinal Chemistry. November 2008, 51 (21): 6808–28. PMC 3088499 可免费查阅. PMID 18847250. doi:10.1021/jm800771x.
  7. Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB. . Bioorganic & Medicinal Chemistry Letters. February 2010, 20 (3): 935–8. PMC 3252747 可免费查阅. PMID 20045641. doi:10.1016/j.bmcl.2009.12.064.
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