AB-PINACA

AB-PINACA是一种有机化合物，化学式为C18H26N4O2。它最初由辉瑞公司于2009年作为镇痛药开发，[1][2]并在2012年于日本首次被鉴定为合成大麻素。[3]

AB-PINACA
法律規範狀態
法律規範
识别
  • N-[(1S)-1-(Aminocarbonyl)-2-methylpropyl]-1-pentyl-1H-indazole-3-carboxamide
CAS号1445752-09-9  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
化学
化学式C18H26N4O2
摩尔质量330.43 g·mol−1
3D模型（JSmol）
  • CCCCCn1c2ccccc2c(n1)C(=O)N[C@@H](C(C)C)C(=O)N
  • InChI=1S/C18H26N4O2/c1-4-5-8-11-22-14-10-7-6-9-13(14)16(21-22)18(24)20-15(12(2)3)17(19)23/h6-7,9-10,12,15H,4-5,8,11H2,1-3H3,(H2,19,23)(H,20,24)/t15-/m0/s1
  • Key:GIMHPAQOAAZSHS-HNNXBMFYSA-N

它是潜在的CB1受体（Ki = 2.87 nM，EC50 = 1.2 nM）和CB2受体（Ki = 0.88 nM，EC50 = 2.5 nM）的激动剂。[4][5]

这种合成大麻素有不少相关死亡和住院病例报告。[6]

参见
  • 5F-AB-PINACA
  • 5F-ADB
  • 5F-AMB
  • 5F-APINACA
  • 5F-CUMYL-PINACA
  • AB-CHFUPYCA
  • AB-FUBINACA
  • AB-PICA
  • ADB-CHMINACA
  • ADB-FUBINACA
  • ADB-PINACA
  • ADBICA
  • APICA
  • APINACA
  • MDMB-CHMICA
  • PX-3

参考文献
  1. . Cayman Chemical. [25 June 2015]. （原始内容存档于2015-06-26）.
  2. . [2023-01-26]. （原始内容存档于2016-05-27）.
  3. Uchiyama N, Matsuda S, Wakana D, Kikura-Hanajiri R, Goda Y. . Forensic Toxicology. 2012, 31: 93–100. S2CID 25242453. doi:10.1007/s11419-012-0171-4.
  4. Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, et al. . ACS Chemical Neuroscience. September 2015, 6 (9): 1546–59. PMID 26134475. doi:10.1021/acschemneuro.5b00112.
  5. Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, et al. . The Journal of Pharmacology and Experimental Therapeutics. September 2015, 354 (3): 328–39 [2023-01-26]. PMC 4538877 可免费查阅. PMID 26105953. doi:10.1124/jpet.115.225326. （原始内容存档于2023-01-30）.
  6. Trecki J, Gerona RR, Schwartz MD. . The New England Journal of Medicine. July 2015, 373 (2): 103–7. PMID 26154784. doi:10.1056/NEJMp1505328.
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