DLG3

DLG3
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1UM7、2FE5、2I1N
識別號
别名	DLG3；, MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3, XLID90
外部ID	OMIM：300189 MGI：1888986 HomoloGene：41157 GeneCards：DLG3
相關疾病
	non-syndromic X-linked intellectual disability[1]
基因位置（人类）
染色体	X染色體[2]
终止	70,505,490 bp[2]
基因位置（小鼠）
染色体	小鼠X染色体[3]
终止	99,862,016 bp[3]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• phosphatase binding; • PDZ domain binding; • protein domain specific binding; • guanylate kinase activity; • 激酶结合; • protein C-terminus binding; • 血浆蛋白结合; • ionotropic glutamate receptor binding; • protein phosphatase binding; • 泛素蛋白连接酶结合; • ligand-gated ion channel activity; • structural constituent of postsynaptic density;
細胞組分	• 細胞質; • postsynaptic membrane; • 突触后致密物质; • cell-cell junction; • 双细胞紧密连接; • 生长锥; • 细胞膜; • 突触; • dendritic shaft; • neuronal cell body; • basolateral plasma membrane; • AMPA glutamate receptor complex; • ionotropic glutamate receptor complex; • 細胞外空間; • 细胞质基质; • 细胞连接; • 神经肌肉接点; • neuron projection; • postsynaptic density membrane; • glutamatergic synapse; • postsynaptic density, intracellular component;
生物學過程	• receptor localization to synapse; • negative regulation of phosphatase activity; • establishment of planar polarity; • receptor clustering; • 神經系統的發育; • establishment or maintenance of epithelial cell apical/basal polarity; • negative regulation of cell population proliferation; • ion transmembrane transport; • GMP metabolic process; • GDP metabolic process; • 化学性突触传递; • MAPK cascade; • positive regulation of protein tyrosine kinase activity; • cell-cell adhesion; • regulation of postsynaptic membrane neurotransmitter receptor levels; • maintenance of postsynaptic density structure; • regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
直系同源
	1741
	53310
	ENSG00000082458
	ENSMUSG00000000881
	Q92796
	P70175
	NM_001166278; NM_020730; NM_021120
	NM_001177778; NM_001177779; NM_001177780; NM_001290402; NM_016747
	NP_001159750; NP_065781; NP_066943
	NP_001171249; NP_001171250; NP_001171251; NP_001277331; NP_058027
	維基數據

盘状大同系物3（英語：，简称DLG3），也被称为神经内分泌-DLG（英語：）或突触相关蛋白102（英語：，简称SAP-102），是一种由人体DLG3基因编码的蛋白质。[6][7] DLG3是膜相关鸟苷酸激酶（英語：，简称MAGUK）蛋白总科的一种。

与其它蛋白的相互作用

DLG3已经被发现可以与以下蛋白相互作用:

APC,[8]
CRIPT,[9]
DLG4,[10]
EXOC3,[11]
EXOC4,[11]
GRIN2A,[9][12]
GRIN2B,[9][11][12][13]
GRIN2C,[9]
KCNJ12[14]
PTK2B,[15] and
SYNGAP1.[16]

模式生物

*Dlg3* 基因剔除小鼠表现型
特征	表现型
所有可用数据来自[17][18]
外周血白细胞（6周）	正常
胰岛素	正常
血液（6周）	正常
P14上纯合子存活能力	正常
纯合子生育能力	正常
一般性意见	异常
体重	正常
神经系统评估	正常
抓握能力	正常
畸形学	正常
间接热量	正常
葡萄糖耐性测试	正常
听觉脑干反应	正常
DEXA	正常
X光成像	正常
眼睛形态	正常
临床用化学	正常
血液（16周）	正常
外周血白细胞（16周）	正常
心脏重量	正常
沙门氏菌感染	正常
细胞毒性T细胞的功能	正常
脾免疫	正常
肠系膜淋巴结免疫	正常
骨髓免疫	正常
表皮免疫的组成	正常
流感威胁	正常

被用来研究DLG3的模式生物之一是称作Dlg3^{tm1a(EUCOMM)Wtsi}的条件性基因剔除后的小鼠族系，由位于英国的桑格中心（Wellcome Trust Sanger Institute）提供。[19] 其雄性与雌性个体都经历了标准化的表现型筛查[17]，以确保基因剔除的结果。[20][21][22][23] 此外，其深度的免疫学表现型也被额外筛选。[18]

参考资料

.
GRCh38: Ensembl release 89: ENSG00000082458 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000881 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Stathakis DG, Lee D, Bryant PJ. . Genomics. Aug 1998, 49 (2): 310–3. PMID 9598320. doi:10.1006/geno.1998.5243.
. （原始内容存档于2010-03-08）.
Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H. . Oncogene. May 1997, 14 (20): 2425–33. PMID 9188857. doi:10.1038/sj.onc.1201087.
Lim IA, Hall DD, Hell JW. . J. Biol. Chem. Jun 2002, 277 (24): 21697–711. PMID 11937501. doi:10.1074/jbc.M112339200.
Masuko N, Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H. . J. Biol. Chem. Feb 1999, 274 (9): 5782–90. PMID 10026200. doi:10.1074/jbc.274.9.5782.
Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ. . Nat. Cell Biol. Jun 2003, 5 (6): 520–30. PMID 12738960. doi:10.1038/ncb990.
Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC. . Science. Sep 1997, 277 (5331): 1511–5. PMID 9278515. doi:10.1126/science.277.5331.1511.
Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y. . Am. J. Physiol., Cell Physiol. Jun 2002, 282 (6): C1396–403. PMID 11997254. doi:10.1152/ajpcell.00615.2001.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA. . J. Biol. Chem. May 2004, 279 (21): 22331–46. PMID 15024025. doi:10.1074/jbc.M400285200.
Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW. . J. Biol. Chem. Apr 2003, 278 (17): 15040–8. PMID 12576483. doi:10.1074/jbc.M212825200.
Kim JH, Liao D, Lau LF, Huganir RL. . Neuron. Apr 1998, 20 (4): 683–91. PMID 9581761. doi:10.1016/S0896-6273(00)81008-9.
. [2018-01-23]. （原始内容存档于2016-01-26）.
.
Gerdin AK. . Acta Ophthalmologica. 2010, 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A. . Nature. Jun 2011, 474 (7351): 337–42. PMC 3572410 . PMID 21677750. doi:10.1038/nature10163.
Dolgin E. . Nature. Jun 2011, 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a.
Collins FS, Rossant J, Wurst W. . Cell. Jan 2007, 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018.
White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. . Cell. 2013, 154 (2): 452–64. PMC 3717207 . PMID 23870131. doi:10.1016/j.cell.2013.06.022.

进一步阅读

Lau LF, Mammen A, Ehlers MD, et al. . J. Biol. Chem. 1996, 271 (35): 21622–8. PMID 8702950. doi:10.1074/jbc.271.35.21622.
Müller BM, Kistner U, Kindler S, et al. . Neuron. 1996, 17 (2): 255–65. PMID 8780649. doi:10.1016/S0896-6273(00)80157-9.
Takeuchi M, Hata Y, Hirao K, et al. . J. Biol. Chem. 1997, 272 (18): 11943–51. PMID 9115257. doi:10.1074/jbc.272.18.11943.
Makino K, Kuwahara H, Masuko N, et al. . Oncogene. 1997, 14 (20): 2425–33. PMID 9188857. doi:10.1038/sj.onc.1201087.
Irie M, Hata Y, Takeuchi M, et al. . Science. 1997, 277 (5331): 1511–5. PMID 9278515. doi:10.1126/science.277.5331.1511.
Kim JH, Liao D, Lau LF, Huganir RL. . Neuron. 1998, 20 (4): 683–91. PMID 9581761. doi:10.1016/S0896-6273(00)81008-9.
Butz S, Okamoto M, Südhof TC. . Cell. 1998, 94 (6): 773–82. PMID 9753324. doi:10.1016/S0092-8674(00)81736-5.
Garcia EP, Mehta S, Blair LA, et al. . Neuron. 1998, 21 (4): 727–39. PMID 9808460. doi:10.1016/S0896-6273(00)80590-5.
Masuko N, Makino K, Kuwahara H, et al. . J. Biol. Chem. 1999, 274 (9): 5782–90. PMID 10026200. doi:10.1074/jbc.274.9.5782.
Kuwahara H, Araki N, Makino K, et al. . J. Biol. Chem. 1999, 274 (45): 32204–14. PMID 10542258. doi:10.1074/jbc.274.45.32204.
Nagase T, Ishikawa K, Kikuno R, et al. . DNA Res. 2000, 6 (5): 337–45. PMID 10574462. doi:10.1093/dnares/6.5.337.
Firestein BL, Firestein BL, Brenman JE, et al. . Neuron. 2000, 24 (3): 659–72. PMID 10595517. doi:10.1016/S0896-6273(00)81120-4.
Garcia RA, Vasudevan K, Buonanno A. . Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (7): 3596–601. PMC 16285 . PMID 10725395. doi:10.1073/pnas.070042497.
Husi H, Ward MA, Choudhary JS, et al. . Nat. Neurosci. 2000, 3 (7): 661–9. PMID 10862698. doi:10.1038/76615.
Inagaki S, Ohoka Y, Sugimoto H, et al. . J. Biol. Chem. 2001, 276 (12): 9174–81. PMID 11134026. doi:10.1074/jbc.M009051200.
DeMarco SJ, Strehler EE. . J. Biol. Chem. 2001, 276 (24): 21594–600. PMID 11274188. doi:10.1074/jbc.M101448200.
Russwurm M, Wittau N, Koesling D. . J. Biol. Chem. 2002, 276 (48): 44647–52. PMID 11572861. doi:10.1074/jbc.M105587200.
Lim IA, Hall DD, Hell JW. . J. Biol. Chem. 2002, 277 (24): 21697–711. PMID 11937501. doi:10.1074/jbc.M112339200.
Cai C, Coleman SK, Niemi K, Keinänen K. . J. Biol. Chem. 2002, 277 (35): 31484–90. PMID 12070168. doi:10.1074/jbc.M204354200.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000082458 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000000881 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598320-6] Stathakis DG, Lee D, Bryant PJ. . Genomics. Aug 1998, 49 (2): 310–3. PMID 9598320. doi:10.1006/geno.1998.5243.

[7] . （原始内容存档于2010-03-08）.

[pmid9188857-8] Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H. . Oncogene. May 1997, 14 (20): 2425–33. PMID 9188857. doi:10.1038/sj.onc.1201087.

[pmid11937501-9] Lim IA, Hall DD, Hell JW. . J. Biol. Chem. Jun 2002, 277 (24): 21697–711. PMID 11937501. doi:10.1074/jbc.M112339200.

[pmid10026200-10] Masuko N, Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H. . J. Biol. Chem. Feb 1999, 274 (9): 5782–90. PMID 10026200. doi:10.1074/jbc.274.9.5782.

[pmid12738960-11] Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ. . Nat. Cell Biol. Jun 2003, 5 (6): 520–30. PMID 12738960. doi:10.1038/ncb990.

[pmid9278515-12] Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC. . Science. Sep 1997, 277 (5331): 1511–5. PMID 9278515. doi:10.1126/science.277.5331.1511.

[pmid11997254-13] Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y. . Am. J. Physiol., Cell Physiol. Jun 2002, 282 (6): C1396–403. PMID 11997254. doi:10.1152/ajpcell.00615.2001.

[pmid15024025-14] Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA. . J. Biol. Chem. May 2004, 279 (21): 22331–46. PMID 15024025. doi:10.1074/jbc.M400285200.

[pmid12576483-15] Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW. . J. Biol. Chem. Apr 2003, 278 (17): 15040–8. PMID 12576483. doi:10.1074/jbc.M212825200.

[pmid9581761-16] Kim JH, Liao D, Lau LF, Huganir RL. . Neuron. Apr 1998, 20 (4): 683–91. PMID 9581761. doi:10.1016/S0896-6273(00)81008-9.

[IMPCsearch_ref-17] . [2018-01-23]. （原始内容存档于2016-01-26）.

[iii_ref-18] .

[mgp_reference-19] Gerdin AK. . Acta Ophthalmologica. 2010, 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.

[pmid21677750-20] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A. . Nature. Jun 2011, 474 (7351): 337–42. PMC 3572410 . PMID 21677750. doi:10.1038/nature10163.

[mouse_library-21] Dolgin E. . Nature. Jun 2011, 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a.

[mouse_for_all_reasons-22] Collins FS, Rossant J, Wurst W. . Cell. Jan 2007, 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018.

[pmid23870131-23] White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. . Cell. 2013, 154 (2): 452–64. PMC 3717207 . PMID 23870131. doi:10.1016/j.cell.2013.06.022.