KIRREL

類IRRE系屬(果蠅); ()
标识
代号	KIRREL; NEPH1
扩展标识	遗传学：607428 同源基因：10089 GeneCards: KIRREL Gene
基因本体论描述
分子功能	· protein binding; · myosin binding;
细胞成分	· plasma membrane; · cell-cell junction; · integral to membrane; · dendritic shaft; · perinuclear region of cytoplasm;
生物过程	· negative regulation of protein phosphorylation; · excretion; · cell-cell adhesion; · positive regulation of actin filament polymerization;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

KIRREL（、類IRRE蛋白1系屬、亦被稱為NEPH1）是一種由KIRREL基因所編碼的人類蛋白質。[1][2]

NEPH1是屬於「類腎病蛋白樣蛋白質家族」的成員，其包括NEPH2（MIM607761）及NEPH3（KIRREL2、MIM 607762）。這些蛋白的「胞質結構域」（cytoplasmic domain）與足蛋白（NPHS2；MIM 604766）的C末端交互作用。NEPH1用表達腎臟足細胞濾過裂隙，細胞涉及確保血液的大小及電荷選擇性的超濾作用（Sellin et al., 2003）。[由OMIM供給][2]

交互作用

KIRREL已顯示出與腎病蛋白[3][4] 及緊密接頭蛋白1（Tight junction protein 1）[3][5]有蛋白質交互作用。

註釋

Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G. . FASEB J. Jan 2003, 17 (1): 115–7. PMID 12424224. doi:10.1096/fj.02-0242fje.
. （原始内容存档于2019-10-17）.
Liu, Gang; Kaw Beenu; Kurfis Jayson; Rahmanuddin Syed; Kanwar Yashpal S; Chugh Sumant S. . J. Clin. Invest. (United States). Jul 2003, 112 (2): 209–21. ISSN 0021-9738. PMC 164293 . PMID 12865409. doi:10.1172/JCI18242.
Gerke, Peter; Huber Tobias B; Sellin Lorenz; Benzing Thomas; Walz Gerd. . J. Am. Soc. Nephrol. (United States). Apr 2003, 14 (4): 918–26. ISSN 1046-6673. PMID 12660326. doi:10.1097/01.ASN.0000057853.05686.89.
Huber, Tobias B; Schmidts Miriam; Gerke Peter; Schermer Bernhard; Zahn Anne; Hartleben Björn; Sellin Lorenz; Walz Gerd; Benzing Thomas. . J. Biol. Chem. (United States). Apr 2003, 278 (15): 13417–21. ISSN 0021-9258. PMID 12578837. doi:10.1074/jbc.C200678200.

延伸閱讀

Donoviel DB; Freed DD; Vogel H; et al. . Mol. Cell. Biol. 2001, 21 (14): 4829–36. PMC 87176 . PMID 11416156. doi:10.1128/MCB.21.14.4829-4836.2001.
Strausberg RL; Feingold EA; Grouse LH; et al. . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Huber TB; Schmidts M; Gerke P; et al. . J. Biol. Chem. 2003, 278 (15): 13417–21. PMID 12578837. doi:10.1074/jbc.C200678200.
Barletta GM; Kovari IA; Verma RK; et al. . J. Biol. Chem. 2003, 278 (21): 19266–71. PMID 12646566. doi:10.1074/jbc.M301279200.
Gerke P; Huber TB; Sellin L; et al. . J. Am. Soc. Nephrol. 2003, 14 (4): 918–26. PMID 12660326. doi:10.1097/01.ASN.0000057853.05686.89.
Liu G; Kaw B; Kurfis J; et al. . J. Clin. Invest. 2003, 112 (2): 209–21. PMC 164293 . PMID 12865409. doi:10.1172/JCI18242.
Ota T; Suzuki Y; Nishikawa T; et al. . Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Brill LM; Salomon AR; Ficarro SB; et al. . Anal. Chem. 2004, 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d.
Gerhard DS; Wagner L; Feingold EA; et al. . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kitamura A; Tsukaguchi H; Iijima K; et al. . Nephrol. Dial. Transplant. 2007, 21 (11): 3133–8. PMID 16968734. doi:10.1093/ndt/gfl347.

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[pmid12424224-1] Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G. . FASEB J. Jan 2003, 17 (1): 115–7. PMID 12424224. doi:10.1096/fj.02-0242fje.

[entrez-2] . （原始内容存档于2019-10-17）.

[pmid12865409-3] Liu, Gang; Kaw Beenu; Kurfis Jayson; Rahmanuddin Syed; Kanwar Yashpal S; Chugh Sumant S. . J. Clin. Invest. (United States). Jul 2003, 112 (2): 209–21. ISSN 0021-9738. PMC 164293 . PMID 12865409. doi:10.1172/JCI18242.

[pmid12660326-4] Gerke, Peter; Huber Tobias B; Sellin Lorenz; Benzing Thomas; Walz Gerd. . J. Am. Soc. Nephrol. (United States). Apr 2003, 14 (4): 918–26. ISSN 1046-6673. PMID 12660326. doi:10.1097/01.ASN.0000057853.05686.89.

[pmid12578837-5] Huber, Tobias B; Schmidts Miriam; Gerke Peter; Schermer Bernhard; Zahn Anne; Hartleben Björn; Sellin Lorenz; Walz Gerd; Benzing Thomas. . J. Biol. Chem. (United States). Apr 2003, 278 (15): 13417–21. ISSN 0021-9258. PMID 12578837. doi:10.1074/jbc.C200678200.