NNC 45-0095

NNC 45-0095是一种含氮有机化合物,化学式C18H17NO,可作为非甾体選擇性雌激素受體調節物(SERMs),由诺和诺德开发,用于治疗骨質疏鬆症,从未上市销售。[1][2][3][4][5]

NNC 45-0095
臨床資料
其他名稱NNC-450095
藥物類別選擇性雌激素受體調節物
识别
  • 4-(1-ethylpyrrolo[2,1,5-cd]indolizin-2-yl)phenol
CAS号217318-90-6
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C18H15NO
摩尔质量261.32 g·mol−1
3D模型(JSmol
  • CCC1=C(C2=CC=C3N2C1=CC=C3)C4=CC=C(C=C4)O
  • InChI=1S/C18H15NO/c1-2-15-16-5-3-4-13-8-11-17(19(13)16)18(15)12-6-9-14(20)10-7-12/h3-11,20H,2H2,1H3
  • Key:GBHFDPQPLXKNIU-UHFFFAOYSA-N

参考文献

  1. Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, et al. . Bioorganic & Medicinal Chemistry Letters. February 2000, 10 (4): 399–402. PMID 10714509. doi:10.1016/S0960-894X(00)00015-9.
  2. Sharma V, Kumar V. . Medicinal Chemistry Research. 2014, 23 (8): 3593–3606. ISSN 1054-2523. S2CID 2643469. doi:10.1007/s00044-014-0940-1.
  3. Wallace OB, Richardson TI, Dodge JA. . Current Topics in Medicinal Chemistry. 2003, 3 (14): 1663–1682. PMID 14683521. doi:10.2174/1568026033451727.
  4. Meegan MJ, Lloyd DG. . Atta-ur-Rahman, Reitz AB (编). 2. Bentham Science Publishers. January 2005: 183–231 (206). ISBN 978-1-60805-205-9. |issue=被忽略 (帮助)
  5. . AdisInsight. Springer Nature Switzerland AG.
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