O-1918

O-1918是一种人工合成的有机化合物，分子式C19H26O2，化学结构上与大麻二酚相似，可作为前孤儿受体G蛋白偶联受体GPR18和GPR55的受体拮抗剂。[1][2][3][4][5]

O-1918
识别
  • 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene
CAS号536697-79-7  checkY
PubChem CID
UNII
CompTox Dashboard (EPA)
化学
化学式C19H26O2
摩尔质量286.19
3D模型（JSmol）
  • CC1=C[C@@H](C2=C(OC)C=C(C)C=C2OC)[C@H](C(C)=C)CC1

参考文献
  1. Offertáler L, Mo FM, Bátkai S, et al. . Molecular Pharmacology. March 2003, 63 (3): 699–705. PMID 12606780. doi:10.1124/mol.63.3.699.
  2. Zakrzeska A, Schlicker E, Baranowska M, et al. . British Journal of Pharmacology. June 2010, 160 (3): 574–84. PMC 2931558 可免费查阅. PMID 20105178. doi:10.1111/j.1476-5381.2009.00579.x.
  3. Schuelert N, McDougall JJ. . Neuroscience Letters. August 2011, 500 (1): 72–6. PMID 21683763. S2CID 3410391. doi:10.1016/j.neulet.2011.06.004.
  4. Szczesniak AM, Maor Y, Robertson H, et al. . Journal of Ocular Pharmacology and Therapeutics. October 2011, 27 (5): 427–35. PMID 21770780. doi:10.1089/jop.2011.0041.
  5. Caldwell MD, Hu SS, Viswanathan S, et al. . British Journal of Pharmacology. June 2013, 169 (4): 834–43. PMC 3687663 可免费查阅. PMID 23461720. doi:10.1111/bph.12136.
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