RU-16117

RU-16117（化学名：11α-甲氧基乙炔雌二醇，与莫克雌醇是11α-差向异构体）是一种雌激素类药物，用于治疗雌激素缺乏综合症，如骨质疏松和潮熱，从未上市销售[1]。

RU-16117
臨床資料
其他名稱11α-Methoxyethinylestradiol; 11α-Methoxy-17α-ethynylestradiol; 11α-Methoxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol
给药途径口服[1]
藥物類別Estrogen; Estrogen ether
识别
  • (8S,9S,11R,13S,14S,17R)-17-Ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
CAS号61665-15-4
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
化学
化学式C21H26O3
摩尔质量326.44 g·mol−1
3D模型（JSmol）
水溶性0.0012 g（25 °C）[2] mg/mL (20 °C)
  • C[C@]12C[C@H]([C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O)OC
  • InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18+,19+,20-,21-/m0/s1
  • Key:MTMZZIPTQITGCY-QHOCJJNXSA-N

参考资料
  1. Raynaud JP, Azadian-Boulanger G, Bouton MM, Colin MC, Faure N, Fernand-Proulx L, Gautray JP, Husson JM, Jolivet A, Kelly P. . J. Steroid Biochem. April 1984, 20 (4B): 981–93. PMID 6427528. doi:10.1016/0022-4731(84)90008-6.
  2. Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-11-30].
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