Ro 5-3663
Ro 5-3663是一种有机化合物，化学式为C10H10N2O，其化学名为1,3-二氢-5-甲基-2H-1,4-苯二氮䓬-2-酮。它可以2'-氨基苯乙酮和N-叔丁氧羰基甘氨酸（或N-芴甲氧羰基甘氨酸[1]）为原料反应制得。[2]它和苯甲醇（或异丙醇）、三丁基膦、DIAD在三氯甲烷中反应，可以得到1-苄基-Ro 5-3663或1-异丙基-Ro 5-3663。[1]
| Ro 5-3663 | |
|---|---|
 | |
| 别名 | 5-甲基-1H-苯并[e][1,4]二氮杂环庚三烯-2(3H)-酮 |
| 识别 | |
| CAS号 | 70656-87-0  |
| PubChem | 135432558 |
| SMILES |
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| 性质 | |
| 化学式 | C10H10N2O |
| 摩尔质量 | 174.2 g·mol−1 |
| 外观 | 白色固体[1] |
| 熔点 | 178~181 °C[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献
- Kwan-Young Jung; Steven Fletcher. Fine-tuning the chemo- and regioselective alkylation of 1,4-benzodiazepines: further applications of the Mitsunobu reaction. MedChemComm, 2012. doi:10.1039/C2MD20123B.
- Romain Siegrist, Davide Pozzi, Gaël Jacob, Caterina Torrisi, Kilian Colas, Bertrand Braibant, Jacques Mawet, Thomas Pfeifer, Ruben de Kanter, Catherine Roch, Melanie Kessler, Richard Moon, Olivier Corminboeuf, Olivier Bezençon. Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. Journal of Medicinal Chemistry (2016), 59 (23), 10661-10675. doi:10.1021/acs.jmedchem.6b01356.
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