UBTF

Upstream binding transcription factor, RNA polymerase I; RNA聚合酶I上游结合因子
	PDB rendering based on 1k99.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1K99, 1L8Y, 1L8Z, 2HDZ
标识
代号	UBTF; NOR-90; UBF; UBF-1; UBF1
扩展标识	遗传学：600673 鼠基因：98512 同源基因：7970 GeneCards: UBTF Gene
基因本体论描述
分子功能	· DNA binding; · protein binding;
细胞成分	· nucleoplasm; · nucleolus; · cytoplasm;
生物过程	· blastocyst growth; · regulation of transcription from RNA polymerase I promoter; · transcription from RNA polymerase I promoter; · transcription initiation from RNA polymerase I promoter; · transcription elongation from RNA polymerase I promoter; · termination of RNA polymerase I transcription; · embryo implantation; · gene expression; · positive regulation of transcription from RNA polymerase I promoter;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

核仁转录因子1（Nucleolar transcription factor 1）又叫上游结合转录因子（Upstream binding transcription factor，缩写UBTF）或上游结合因子1（Upstream binding factor 1，缩写UBF1）是一种由人类基因UBTF 所编码的蛋白质[1][2]。

功能

UBTF是18S、5.8S和28S的核糖体RNA的转录所必须的转录因子，和SL1因子（一个四聚体，包括一个TATA结合蛋白和3个转录辅助因子TAF1）共同起作用。在人体中存在94和97kD的两种UBF多肽链。UBF是一种核仁磷酸化蛋白（nucleolar phosphoprotein），同时具有DNA结合结构域和反式激活结构域，通过HMG盒结合到人rRNA启动子的核心与上游部位。[2]

相互作用

UBTF已知能与酪蛋白激酶2α亚基[3]、TAF1C[4][5]、视网膜母细胞瘤蛋白[6]和TAF1[7]进行交互作用。

参考文献

Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK. . Genomics. May 1997, 41 (1): 135–8. PMID 9126496. doi:10.1006/geno.1997.4647.
.
Voit, R; Kuhn A, Sander E E, Grummt I. . Nucleic Acids Res. (ENGLAND). July 1995, 23 (14): 2593–9. ISSN 0305-1048. PMC 307079 . PMID 7651819. doi:10.1093/nar/23.14.2593.
Voit, R; Grummt I. . Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13631–6. ISSN 0027-8424. PMC 61092 . PMID 11698641. doi:10.1073/pnas.231071698.
Zhai, W; Comai L. . Mol. Cell. Biol. (UNITED STATES). August 2000, 20 (16): 5930–8. ISSN 0270-7306. PMC 86070 . PMID 10913176. doi:10.1128/MCB.20.16.5930-5938.2000.
Hannan, K M; Hannan R D, Smith S D, Jefferson L S, Lun M, Rothblum L I. . Oncogene (ENGLAND). October 2000, 19 (43): 4988–99. ISSN 0950-9232. PMID 11042686. doi:10.1038/sj.onc.1203875.
Lin, Chih-Yin; Tuan JoAnn, Scalia Pierluigi, Bui Tiffany, Comai Lucio. . Curr. Biol. (England). Dec 2002, 12 (24): 2142–6. ISSN 0960-9822. PMID 12498690. doi:10.1016/S0960-9822(02)01389-1.

延伸阅读

Chan EK, Imai H, Hamel JC, Tan EM. . J. Exp. Med. 1991, 174 (5): 1239–44. PMC 2119007 . PMID 1940801. doi:10.1084/jem.174.5.1239.
Jantzen HM, Admon A, Bell SP, Tjian R. . Nature. 1990, 344 (6269): 830–6. PMID 2330041. doi:10.1038/344830a0.
Bell SP, Learned RM, Jantzen HM, Tjian R. . Science. 1988, 241 (4870): 1192–7. PMID 3413483. doi:10.1126/science.3413483.
Voit R, Kuhn A, Sander EE, Grummt I. . Nucleic Acids Res. 1995, 23 (14): 2593–9. PMC 307079 . PMID 7651819. doi:10.1093/nar/23.14.2593.
Hempel WM; Cavanaugh AH; Hannan RD; et al. . Mol. Cell. Biol. 1996, 16 (2): 557–63. PMC 231034 . PMID 8552083. 已忽略未知参数|author-separator= (帮助)
Hanada K; Song CZ; Yamamoto K; et al. . EMBO J. 1996, 15 (9): 2217–26. PMC 450146 . PMID 8641287. 已忽略未知参数|author-separator= (帮助)
Pluta AF, Earnshaw WC. . J. Biol. Chem. 1996, 271 (31): 18767–74. PMID 8702533. doi:10.1074/jbc.271.31.18767.
Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB. . Chromosoma. 1998, 106 (8): 493–502. PMID 9426281. doi:10.1007/s004120050271.
Voit R, Hoffmann M, Grummt I. . EMBO J. 1999, 18 (7): 1891–9. PMC 1171274 . PMID 10202152. doi:10.1093/emboj/18.7.1891.
Liu CJ, Wang H, Lengyel P. . EMBO J. 1999, 18 (10): 2845–54. PMC 1171365 . PMID 10329630. doi:10.1093/emboj/18.10.2845.
Hannan KM; Hannan RD; Smith SD; et al. . Oncogene. 2000, 19 (43): 4988–99. PMID 11042686. doi:10.1038/sj.onc.1203875. 已忽略未知参数|author-separator= (帮助)
Kalousek I, Krízková P. . Cell. Mol. Biol. (Noisy-le-grand). 2001, 46 (7): 1163–71. PMID 11075946.
Pelletier G; Stefanovsky VY; Faubladier M; et al. . Mol. Cell. 2002, 6 (5): 1059–66. PMID 11106745. doi:10.1016/S1097-2765(00)00104-0. 已忽略未知参数|author-separator= (帮助)
Miller G; Panov KI; Friedrich JK; et al. . EMBO J. 2001, 20 (6): 1373–82. PMC 145519 . PMID 11250903. doi:10.1093/emboj/20.6.1373. 已忽略未知参数|author-separator= (帮助)
Seither P, Iben S, Thiry M, Grummt I. . Biol. Chem. 2002, 382 (8): 1163–70. PMID 11592397. doi:10.1515/BC.2001.146.
Voit R, Grummt I. . Proc. Natl. Acad. Sci. U.S.A. 2002, 98 (24): 13631–6. PMC 61092 . PMID 11698641. doi:10.1073/pnas.231071698.
Stefanovsky VY; Pelletier G; Hannan R; et al. . Mol. Cell. 2002, 8 (5): 1063–73. PMID 11741541. doi:10.1016/S1097-2765(01)00384-7. 已忽略未知参数|author-separator= (帮助)
Andersen JS; Lyon CE; Fox AH; et al. . Curr. Biol. 2002, 12 (1): 1–11. PMID 11790298. doi:10.1016/S0960-9822(01)00650-9. 已忽略未知参数|author-separator= (帮助)
Dühr S; Torres-Montaner A; Astola A; et al. . DNA Seq. 2002, 12 (4): 267–72. PMID 11916260. doi:10.3109/10425170109025001. 已忽略未知参数|author-separator= (帮助)

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid9126496-1] Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK. . Genomics. May 1997, 41 (1): 135–8. PMID 9126496. doi:10.1006/geno.1997.4647.

[entrez-2] .

[pmid7651819-3] Voit, R; Kuhn A, Sander E E, Grummt I. . Nucleic Acids Res. (ENGLAND). July 1995, 23 (14): 2593–9. ISSN 0305-1048. PMC 307079 . PMID 7651819. doi:10.1093/nar/23.14.2593.

[pmid11698641-4] Voit, R; Grummt I. . Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13631–6. ISSN 0027-8424. PMC 61092 . PMID 11698641. doi:10.1073/pnas.231071698.

[pmid10913176-5] Zhai, W; Comai L. . Mol. Cell. Biol. (UNITED STATES). August 2000, 20 (16): 5930–8. ISSN 0270-7306. PMC 86070 . PMID 10913176. doi:10.1128/MCB.20.16.5930-5938.2000.

[pmid11042686-6] Hannan, K M; Hannan R D, Smith S D, Jefferson L S, Lun M, Rothblum L I. . Oncogene (ENGLAND). October 2000, 19 (43): 4988–99. ISSN 0950-9232. PMID 11042686. doi:10.1038/sj.onc.1203875.

[pmid12498690-7] Lin, Chih-Yin; Tuan JoAnn, Scalia Pierluigi, Bui Tiffany, Comai Lucio. . Curr. Biol. (England). Dec 2002, 12 (24): 2142–6. ISSN 0960-9822. PMID 12498690. doi:10.1016/S0960-9822(02)01389-1.