VGX-1027

VGX-1027也称为GIT-27，分子式为C11H11NO3，是一种免疫調節劑，可阻断TLR2、TLR4、TLR6等Toll样受体的下游信号，因此可减少白介素、TNF-α等多种细胞因子造成的影响。[1][2][3][4][5][6]

VGX-1027
识别
  • 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
CAS号6501-72-0  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C11H11NO3
摩尔质量205.21 g·mol−1
3D模型（JSmol）
  • C1C(ON=C1C2=CC=CC=C2)CC(=O)O
  • InChI=1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
  • Key:MUFJHYRCIHHATF-UHFFFAOYSA-N

参考文献
  1. Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, et al. . Clinical Immunology. June 2007, 123 (3): 311–23. PMID 17449326. doi:10.1016/j.clim.2007.03.004.
  2. Cha JJ, Hyun YY, Lee MH, Kim JE, Nam DH, Song HK, et al. . Endocrinology. June 2013, 154 (6): 2144–55. PMID 23568555. doi:10.1210/en.2012-2080 可免费查阅.
  3. Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, et al. . Cell Death & Disease. May 2015, 6 (5): e1752. PMC 4669704 可免费查阅. PMID 25950482. doi:10.1038/cddis.2015.125.
  4. Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, et al. . Clinical Pharmacology in Drug Development. March 2016, 5 (2): 91–101. PMID 27138022. S2CID 22577185. doi:10.1002/cpdd.193.
  5. Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, et al. . European Journal of Pharmacology. January 2019, 842: 373–383. PMID 30419239. S2CID 53292202. doi:10.1016/j.ejphar.2018.11.010. hdl:10044/1/66292 可免费查阅.
  6. Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Alasmari F, Alasmari AF, et al. . Life Sciences. November 2019, 237: 116930. PMID 31610190. doi:10.1016/j.lfs.2019.116930.
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