胰岛素样生长因子1

胰岛素样生长因子1
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1B9G、1GZR、1GZY、1GZZ、1H02、1H59、1IMX、1PMX、1TGR、1WQJ、2DSR、2GF1、3GF1、3LRI、1BQT、4XSS
标识符
代号	IGF1
扩展标识	OMIM：147440；MGI：96432；HomoloGene：515；GeneCards：IGF1；OMA：IGF1 - orthologs
基因位置（人类）
染色体	12號染色體
终止	102,481,744 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	87,772,904 bp
RNA表达模式
	Top expressed in
	tail of epididymis; ; tendon of biceps brachii; ; caput epididymis; ; corpus epididymis;
	Top expressed in
	left lobe of liver; ; stroma of bone marrow;
	查阅更多表达数据
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	hormone activity; insulin receptor binding; 生長因子活性; integrin binding; 血浆蛋白结合; insulin-like growth factor receptor binding;
細胞組分	細胞外區域; exocytic vesicle; insulin-like growth factor binding protein complex; platelet alpha granule lumen; insulin-like growth factor ternary complex; alphav-beta3 integrin-IGF-1-IGF1R complex; 细胞膜; 細胞外空間;
生物學過程	positive regulation of transcription regulatory region DNA binding; 骨骼系统的发生; positive regulation of glucose import; muscle organ development; positive regulation of Ras protein signal transduction; response to heat; positive regulation of cardiac muscle hypertrophy; positive regulation of smooth muscle cell migration; 脫氧核糖核酸複製; positive regulation of insulin-like growth factor receptor signaling pathway; phosphatidylinositol 3-kinase signaling; positive regulation of DNA binding; Ras protein signal transduction; 細胞增殖; positive regulation of mitotic nuclear division; positive regulation of trophectodermal cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of fibroblast proliferation; ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; cell activation; negative regulation of oocyte development; positive regulation of transcription, DNA-templated; bone mineralization involved in bone maturation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPK cascade; proteoglycan biosynthetic process; positive regulation of activated T cell proliferation; positive regulation of epithelial cell proliferation; negative regulation of release of cytochrome c from mitochondria; protein stabilization; myotube cell development; positive regulation of DNA replication; myoblast proliferation; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; positive regulation of protein secretion; positive regulation of glycoprotein biosynthetic process; 基因調節; phosphatidylinositol-mediated signaling; positive regulation of smooth muscle cell proliferation; 肌肉肥大; Akt/PKB信号通路; regulation of multicellular organism growth; positive regulation of cell migration; platelet degranulation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of phosphatidylinositol 3-kinase signaling; myoblast differentiation; glycolate metabolic process; positive regulation of glycolytic process; negative regulation of smooth muscle cell apoptotic process; 訊息傳遞; positive regulation of transcription by RNA polymerase II; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cell population proliferation; positive regulation of osteoblast differentiation; activation of protein kinase B activity; insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; positive regulation of gene expression; negative regulation of gene expression; cellular response to amyloid-beta; positive regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell apoptotic process; 白细胞介素-1β产生的负调控; 腫瘤壞死因子產生的負調控; negative regulation of neuroinflammatory response; negative regulation of amyloid-beta formation;
	来源：Amigo / QuickGO
直系同源
	3479
	16000
	ENSG00000017427
	ENSMUSG00000020053
	P05019
	P05017
	NM_000618; NM_001111283; NM_001111284; NM_001111285
NM_001111274; NM_001111275; NM_001111276; NM_010512; NM_184052;
	NM_001314010
	NP_000609; NP_001104753; NP_001104754; NP_001104755
	NP_001104744; NP_001104745; NP_001104746; NP_001300939; NP_034642
	维基数据
檢視/編輯人類	檢視/編輯小鼠

胰岛素样生长因子1（英語：Insulin-like growth factor 1，IGF-1）也被称为生长调节素C（somatomedin C），是一个由人类基因 IGF1 编码的蛋白质^[5]^[6]。在1970年代，IGF-1也曾经被称为“酸硫化因子”^[7]，並認為其作用为“不受抑制的胰岛样活力”（nonsuppressible insulin-like activity，NSILA）。

IGF-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物，美卡舍明，用于治疗发育停滞^[8]。

IGF-1蛋白由一个肽链构成，包括70个氨基酸残基和三个分子内二硫键，分子量为7,649道尔顿^[9]。

已经发现,垂体前部的生长激素（GH）分泌受到GH释放激素( GHRH )和生长抑素的调节，GHRH和生长抑素之间的相互作用引起搏动性GH分泌，在青春期最高。GH诱导肝脏中胰岛素样生长因子1的产生，并调节许多其他组织中IGF-1的旁分泌。IGF-1是GH的合成代谢和促有丝分裂活性的介体。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000017427 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.
^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.
^ Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.
^ Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.
^ Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

延伸阅读

Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis?. News Physiol. Sci. 2002, 17: 82–5. PMID 11909998.
Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E. Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity. Ann. Endocrinol. (Paris). 2002, 63 (2 Pt 1): 140–4. PMID 11994678.
Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion. Reviews in endocrine & metabolic disorders. 2003, 3 (4): 357–61. PMID 12424437. doi:10.1023/A:1020957809082.
Dantzer B, Swanson EM. Mediation of vertebrate life histories via insulin-like growth factor-1. Biological Reviews. 2012, 87 (2): 414–429. PMID 21981025. doi:10.1111/j.1469-185X.2011.00204.x.
Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J. IGF-I: from diagnostic to triple-helix gene therapy of solid tumors. Acta Biochim. Pol. 2004, 49 (4): 979–90. PMID 12545204.
Winn N, Paul A, Musaró A, Rosenthal N. Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harb. Symp. Quant. Biol. 2003, 67: 507–18. PMID 12858577. doi:10.1101/sqb.2002.67.507.
Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 2005, 24 (3): 435–44. PMID 14604834. doi:10.1161/01.ATV.0000105902.89459.09.
Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I. Role of insulin-like growth factor I signaling in neurodegenerative diseases. J. Mol. Med. 2004, 82 (3): 156–62. PMID 14647921. doi:10.1007/s00109-003-0499-7.
Rabinovsky ED. The multifunctional role of IGF-1 in peripheral nerve regeneration. Neurol. Res. 2004, 26 (2): 204–10. PMID 15072640. doi:10.1179/016164104225013851.
Rincon M, Muzumdar R, Atzmon G, Barzilai N. The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech. Ageing Dev. 2005, 125 (6): 397–403. PMID 15272501. doi:10.1016/j.mad.2004.03.006.
Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F. Insulin-like growth factor-1 as a vascular protective factor. Circulation. 2005, 110 (15): 2260–5. PMID 15477425. doi:10.1161/01.CIR.0000144309.87183.FB.
Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int. Rev. Cytol. International Review of Cytology. 2005, 243: 215–85. ISBN 9780123646477. PMID 15797461. doi:10.1016/S0074-7696(05)43004-1.
Sandhu MS. Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocrine development. Endocrine Development. 2005, 9: 44–54. ISBN 3-8055-7926-8. PMID 15879687. doi:10.1159/000085755.
Ye P, D'Ercole AJ. Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system. J. Neurosci. Res. 2006, 83 (1): 1–6. PMID 16294334. doi:10.1002/jnr.20688.
Gómez JM. The role of insulin-like growth factor I components in the regulation of vitamin D. Current pharmaceutical biotechnology. 2006, 7 (2): 125–32. PMID 16724947. doi:10.2174/138920106776597621.
Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S. Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). J. Endocrinol. Invest. 2006, 29 (8): 732–7. PMID 17033263. doi:10.1007/bf03344184.
Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. Med. Hypotheses. 2007, 69 (2): 302–6. PMID 17289286. doi:10.1016/j.mehy.2006.11.045.
Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience. 2007, 145 (3): 795–811. PMID 17320297. doi:10.1016/j.neuroscience.2007.01.021.
Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. Am J Psychiatry. October 2007, 164 (10): 1557–60. PMID 17898347. doi:10.1176/appi.ajp.2007.07020233.

外部链接

醫學主題詞表（MeSH）：Insulin-Like+Growth+Factor+I
IGF-1 （页面存档备份，存于互联网档案馆） at Lab Tests Online
IGF-1 （页面存档备份，存于互联网档案馆） recombinant GFP labeled at Protean Ltd. （页面存档备份，存于互联网档案馆）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000017427 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020053 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2982726-5] Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.

[pmid6358902-6] Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.

[7] Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.

[pmid18481900-8] Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.

[pmid632300-9] Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]