Singles
2021 Prague Open
Champion	Barbora Krejčíková
Runner-up	Tereza Martincová
Score	6–2, 6–0
Draw	32
Seeds	8

Simona Halep was the defending champion, but chose not to participate.

Barbora Krejčíková won the title, defeating Tereza Martincová in the final, 6–2, 6–0.

Seeds

Draw

Finals

	Semifinals							Final
	8	Tereza Martincová	6	6
	9	Greet Minnen	3	4
								8	Tereza Martincová	2	0
								2	Barbora Krejčíková	6	6
		Wang Xinyu	1	2
	2	Barbora Krejčíková	6	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	P Kvitová	65	6	4
	Q	R Šramková	77	3	6			Q	R Šramková	4	5
		M Barthel	6	4	3			WC	V Kužmová	6	7
	WC	V Kužmová	2	6	6										WC	V Kužmová	2	2
		L Cabrera	6	2	2										8	T Martincová	6	6
	Q	A Muhammad	3	6	6			Q	A Muhammad	3	4
	PR	S Murray Sharan	1	4				8	T Martincová	6	6
	8	T Martincová	6	6																		8	T Martincová	6	6
	4	M Bouzková	6	4	2																	9	G Minnen	3	4
		S Sanders	3	6	6				S Sanders	4	6	6
	Q	U Radwańska	6	3	1				N Párrizas Díaz	6	3	1
		N Párrizas Díaz	2	6	6											S Sanders	2	1
	LL	A Gasanova	6	4	6										9	G Minnen	6	6
	WC	L Havlíčková	2	6	4			LL	A Gasanova	3	63
		G Gatto-Monticone	0	6	1			9	G Minnen	6	77
	9	G Minnen	6	4	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	7	N Stojanović	65	6	6
	PR	V Diatchenko	77	1	3			7	N Stojanović	6	1	4
	WC	S Stosur	3	6	3				G Min	3	6	6
		G Min	6	2	6											G Min	3	3
		L Küng	2	2												Xin Wang	6	6
		Xin Wang	6	6					Xin Wang	3	7	6
	LL	C Perrin	3	4				LL	E-s Liang	6	5	1
	LL	E-s Liang	6	6																			Xin Wang	1	2
	5	K Siniaková	6	6																		2	B Krejčíková	6	6
	Q	J Burrage	0	4				5	K Siniaková	2	77	6
		M Inglis	2	2				PR	T Smitková	6	63	3
	PR	T Smitková	6	6											5	K Siniaková	3	0
	Q	N Bains	3	2											2	B Krejčíková	6	6
		Y Bonaventure	6	6					Y Bonaventure	62	4
	Q	I Shinikova	2	3				2	B Krejčíková	77	6
	2	B Krejčíková	6	6

Qualifying

Draw

First qualifier

	First round							Qualifying competition
	1	Anastasia Gasanova	6	6
		María Lourdes Carlé	1	3
								1	Anastasia Gasanova	1	1
								10	Jodie Burrage	6	6
	WC	Patricie Kubíková	5	1
	10	Jodie Burrage	7	6

Second qualifier

	First round							Qualifying competition
	2	Asia Muhammad	6	6
	WC	Denisa Hindová	2	0
								2	Asia Muhammad	6	7
								9	Anastasia Zakharova	3	5
	WC	Linda Klimovičová	2	5
	9	Anastasia Zakharova	6	7

Third qualifier

	First round							Qualifying competition
	3	Isabella Shinikova	6	7
		Riya Bhatia	2	5
								3	Isabella Shinikova	6	6
								7	Conny Perrin	2	2
		Miriam Kolodziejová	2	3
	7	Conny Perrin	6	6

Fourth qualifier

	First round							Qualifying competition
								WC	Tereza Valentová	2	2
								12	Naiktha Bains	6	6
	WC	Barbora Miklová	1	0r
	12	Naiktha Bains	6	0

Fifth qualifier

	First round							Qualifying competition
	5	Rebecca Šramková	6	6
	WC	Barbora Palicová	1	4
								5	Rebecca Šramková	6	6
								11	Yuan Yue	3	2
		Tara Moore	5	69
	11	Yuan Yue	7	711

Sixth qualifier

	First round							Qualifying competition
	6	Urszula Radwańska	6	6
	WC	Dominika Šalková	1	1
								6	Urszula Radwańska	6	6
								8/PR	Liang En-shuo	2	4
		Emina Bektas	3	3
	8/PR	Liang En-shuo	6	6

References

• Main Draw
• Qualifying Draw