ADAM2
Identifiers
AliasesADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2
External IDsOMIM: 601533 MGI: 1340894 HomoloGene: 1127 GeneCards: ADAM2
Orthologs
SpeciesHumanMouse
Entrez

2515

11495

Ensembl

ENSG00000104755
ENSG00000276286

ENSMUSG00000022039

UniProt

Q99965

Q60718

RefSeq (mRNA)

NM_001278113
NM_001278114
NM_001464

NM_009618

RefSeq (protein)

NP_001265042
NP_001265043
NP_001455

NP_033748

Location (UCSC)Chr 8: 39.74 – 39.84 MbChr 14: 66.26 – 66.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[5] is an enzyme that in humans is encoded by the ADAM2 gene.[6][7][8]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[8] The other subunit is ADAM1 or alpha-fertilin.[5]

References

  1. 1 2 3 ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022039 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
  6. Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.
  7. Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
  8. 1 2 "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

Further reading


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