Slater has an assignment for Archer and Lana: extract a freelance CIA agent stranded in Buenos Aires. That agent happens to be Conway Stern, who stole the whisper drive to sell to the Chinese government. Conway was a decoy set up by the CIA to ensure the safety of the real plans. After Archer and Conway fight upon seeing each other, Conway tells them he was sent to retrieve a computer file with the identities of every CIA operative in Central and South America and that he needs their help. Ultimately, Conway double-crosses them, intending to sell the files to the Russians. Back home, the search is on for A.J., who has gone missing. She is found in Krieger's lab, where she was taken for research for Krieger's "Cyberneddly Teddly" cyborg, which he has completed.

Lana, Archer, and Ray travel to a mountain climbing resort in the Alps to kill an assassin. Only Archer has forgotten the mission dossier, leaving them without the target's name. They meet the climbing party: Crash McCarren, Mario Sevino of Italy, Michiko Ishikawa of Japan, and Hans Hessler of Germany. Archer then recalls the target being from an Axis powers nation. One by one, Michiko, Mario, and Hans mysteriously die. Archer gets Crash to admit that he is the assassin, that he is Irish, and killed all the other climbers, who were Interpol agents. Archer shoots him, despite being warned of a resulting avalanche. Back home, the gang breaks into Mallory's apartment, only to get poisoned.

Pam's nasty sister Edie is getting married and has overlooked Pam for maid of honor in favor of a woman who stole her old boyfriend. Archer accompanies Pam to Wisconsin, only to be spotted in an airport by Barry Dylan. Barry later kidnaps Pam from the hotel, takes her to an abandoned silo, and calls Archer, who knocks out Edie when she refuses to help. At the farm, all engage in a verbal and physical fight until Pam saves Edie from Barry by shooting him with Archer's explosive shotgun shells. They set the building on fire, and the three leave Barry's mechanical, still-living endoskeleton behind.

Lana leaves A.J. in Archer's care. When she departs, Slater arrives at Archer's with a bullet wound and a Pakistani agent, named Farooq, needing a safe house. Farooq later forces Archer at gunpoint to drive him to the office to hack the mainframe. With A.J. in tow, Archer does, and they find the team playing poker. While the team overpowers Farooq, Pam takes A.J. to the top of the building, à la King Kong.

Lana and Archer travel to Berkeley so that her parents can meet their granddaughter. But when a team of masked gunmen steals Lana's microbiologist father's research, Archer and the Kanes must give chase through the streets of San Francisco in a scene straight out of Bullitt. Meanwhile, Krieger, Pam, Cheryl, Cyril, and Krieger's Virtual Girlfriend run out of gas in the ghetto on their way to league bowling night.

Slater has the gang swindle the Durhani royal family and Gillette lends a hand. The group attempts to steal the hand prints and retinal scans of the Prince of Durhan during a tour of Tunt Manor.

Shocked and disgusted by Archer and Lana's renewed romance, Cyril, Ray, Pam, Cheryl, and Krieger conspire to drive a wedge in between the couple by contacting a certain someone from Archer’s past and staking out his apartment in Krieger’s van. However, even after seeing her, Archer decides to remain loyal to Lana.

Archer takes Lana to Wales for a romantic getaway and end up aiding Welsh separatists.

To save the life of a preeminent scientist who has discovered miniaturization, the team must enter his body and destroy a blood clot.

The team's mission inside Dr. Kovacs goes awry, and they are blacklisted by the CIA.