BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
SymbolBNR
PfamPF02012
Pfam clanCL0434
InterProIPR002860
SCOP21euu / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1dil, 1dim, 1eur, 1eus, 1eut, 1euu, 1kit, 1mr5, 1ms0, 1ms1, 1ms3, 1ms4, 1ms5, 1ms8, 1ms9, 1mz5, 1mz6, 1n1s, 1n1t, 1n1v, 1n1y, 1s0i, 1s0j, 1sli, 1sll, 1sqj, 1w0o, 1w0p, 1w8n, 1w8o, 1wcq, 1wcs, 2a75, 2ags, 2ah2, 2ber, 2bzd, 2ebs, 2fhr, 2jkb, 2sil, 2sim, 2sli, 2vw0, 2vw1, 2vw2, 3b69, 3b7f, 3sil, 3sli, 4sli

Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pili (attachment factors) bind preferentially.

References

  1. Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.
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