Bacterial neuraminidase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1dil, 1dim, 1eur, 1eus, 1eut, 1euu, 1kit, 1mr5, 1ms0, 1ms1, 1ms3, 1ms4, 1ms5, 1ms8, 1ms9, 1mz5, 1mz6, 1n1s, 1n1t, 1n1v, 1n1y, 1s0i, 1s0j, 1sli, 1sll, 1sqj, 1w0o, 1w0p, 1w8n, 1w8o, 1wcq, 1wcs, 2a75, 2ags, 2ah2, 2ber, 2bzd, 2ebs, 2fhr, 2jkb, 2sil, 2sim, 2sli, 2vw0, 2vw1, 2vw2, 3b69, 3b7f, 3sil, 3sli, 4sli

BNR/Asp-box repeat
BNR/Asp-box repeat
	Structure of a bacterial sialidase.
Identifiers
Symbol	BNR
Pfam	PF02012
Pfam clan	CL0434
InterPro	IPR002860
SCOP2	1euu / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1dil, 1dim, 1eur, 1eus, 1eut, 1euu, 1kit, 1mr5, 1ms0, 1ms1, 1ms3, 1ms4, 1ms5, 1ms8, 1ms9, 1mz5, 1mz6, 1n1s, 1n1t, 1n1v, 1n1y, 1s0i, 1s0j, 1sli, 1sll, 1sqj, 1w0o, 1w0p, 1w8n, 1w8o, 1wcq, 1wcs, 2a75, 2ags, 2ah2, 2ber, 2bzd, 2ebs, 2fhr, 2jkb, 2sil, 2sim, 2sli, 2vw0, 2vw1, 2vw2, 3b69, 3b7f, 3sil, 3sli, 4sli

Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pili (attachment factors) bind preferentially.

References

↑ Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.

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[pmid8591030-1] Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.

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Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)